Lucidone

CAS# 19956-53-7

Lucidone

Catalog No. BCN4876----Order now to get a substantial discount!

Product Name & Size Price Stock
Lucidone: 5mg $638 In Stock
Lucidone: 10mg Please Inquire In Stock
Lucidone: 20mg Please Inquire Please Inquire
Lucidone: 50mg Please Inquire Please Inquire
Lucidone: 100mg Please Inquire Please Inquire
Lucidone: 200mg Please Inquire Please Inquire
Lucidone: 500mg Please Inquire Please Inquire
Lucidone: 1000mg Please Inquire Please Inquire

Quality Control of Lucidone

Number of papers citing our products

Chemical structure

Lucidone

3D structure

Chemical Properties of Lucidone

Cas No. 19956-53-7 SDF Download SDF
PubChem ID 11253859 Appearance Yellow powder
Formula C15H12O4 M.Wt 256.3
Type of Compound Chalcones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-hydroxy-4-methoxy-2-[(E)-3-phenylprop-2-enoyl]cyclopenta-2,4-dien-1-one
SMILES COC1=CC(=O)C(=C1O)C(=O)C=CC2=CC=CC=C2
Standard InChIKey ANPTXNYQLGJVRE-BQYQJAHWSA-N
Standard InChI InChI=1S/C15H12O4/c1-19-13-9-12(17)14(15(13)18)11(16)8-7-10-5-3-2-4-6-10/h2-9,18H,1H3/b8-7+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lucidone

The root of Lindera strychnifolia

Biological Activity of Lucidone

Description1. Lucidone has anti-inflammatory activity, the activity might be caused by the inhibition of iNOS and COX-2 expressions through downregulation of NF-kappaB and AP-1 binding. 2. Lucidone has hepatoprotective effect, it-mediated up-regulation of phase-II enzymes and HO-1 via Nrf-2 signaling pathway may provide a pivotal mechanism for its hepatoprotective action. 3. Lucidone may possess antioxidant and anti-inflammatory properties and may be useful for the prevention of free radical-induced skin damage. 4. Dietary intake of lucidone alleviates high fat diet-induced obesity in C57BL/6 mice and reveals the potential of lucidone as a nutraceutical to prevent obesity and consequent metabolic disorders. 5. Lucidone accelerates wound healing through the cooperation of keratinocyte/fibroblast/ ndothelial cell growth and migration and macrophage inflammation via PI3K/AKT, Wnt/β-catenin and NF-κB signaling cascade activation. 6. Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction, it could be a potential lead or supplement for the development of new anti-HCV agent in the future.
TargetsROS | DNA/RNA Synthesis | Nrf2 | PGE | COX | NF-kB | IkB | ERK | p38MAPK | HCV | PPAR | AP-1 | GLUT | NO | TNF-α | HO-1 | TNF-α | NOS | JNK | Wnt/β-catenin | GSK-3 | CDK | p21 | MMP(e.g.TIMP) | PI3K | VEGFR | Akt | IKK

Lucidone Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Lucidone Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Lucidone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9017 mL 19.5084 mL 39.0168 mL 78.0336 mL 97.5419 mL
5 mM 0.7803 mL 3.9017 mL 7.8034 mL 15.6067 mL 19.5084 mL
10 mM 0.3902 mL 1.9508 mL 3.9017 mL 7.8034 mL 9.7542 mL
50 mM 0.078 mL 0.3902 mL 0.7803 mL 1.5607 mL 1.9508 mL
100 mM 0.039 mL 0.1951 mL 0.3902 mL 0.7803 mL 0.9754 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Lucidone

Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction.[Pubmed:23254429]

Antimicrob Agents Chemother. 2013 Mar;57(3):1180-91.

Upon screening of plant-derived natural products against hepatitis C virus (HCV) in the replicon system, we demonstrate that Lucidone, a phytocompound, isolated from the fruits of Lindera erythrocarpa Makino, significantly suppressed HCV RNA levels with 50% effective concentrations of 15 +/- 0.5 muM and 20 +/- 1.1 muM in HCV replicon and JFH-1 infectious assays, respectively. There was no significant cytotoxicity observed at high concentrations, with a 50% cytotoxic concentration of 620 +/- 5 muM. In addition, Lucidone significantly induced heme oxygenase-1 (HO-1) production and led to the increase of its product biliverdin for inducing antiviral interferon response and inhibiting HCV NS3/4A protease activity. Conversely, the anti-HCV activity of Lucidone was abrogated by blocking HO-1 activity or silencing gene expression of HO-1 or NF-E2-related factor 2 (Nrf2) in the presence of Lucidone, indicating that the anti-HCV action of Lucidone was due to the stimulation of Nrf-2-mediated HO-1 expression. Moreover, the combination of Lucidone and alpha interferon, the protease inhibitor telaprevir, the NS5A inhibitor BMS-790052, or the NS5B polymerase inhibitor PSI-7977, synergistically suppressed HCV RNA replication. These findings suggest that Lucidone could be a potential lead or supplement for the development of new anti-HCV agent in the future.

Hepatoprotective effect of lucidone against alcohol-induced oxidative stress in human hepatic HepG2 cells through the up-regulation of HO-1/Nrf-2 antioxidant genes.[Pubmed:22484158]

Toxicol In Vitro. 2012 Aug;26(5):700-8.

Lucidone was previously reported to exhibit anti-inflammatory activity in vitro and in vivo. In the present study, we characterized the mechanisms underlying the hepatoprotective effect of Lucidone against alcohol-induced oxidative stress in vitro. Human hepatoma (HepG2) cells were pretreated with Lucidone (1-10mug/mL) and then hepatotoxicity was stimulated by the addition ethanol (100mM). With response to ethanol-challenge, increased amount of alanine aminotransferase (ALT) and aspirate aminotransferase (AST) release were observed, whereas Lucidone pretreatment significantly inhibited the leakage of AST and ALT in HepG2 cells without appreciable cytotoxic effects. We also found that Lucidone pretreatment significantly decreased ethanol-induced nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA), reactive oxygen species (ROS) and glutathione (GSH) depletion in HepG2 cells. Furthermore, Western blot and quantitative-PCR analyses showed that ethanol-exposure apparently down-regulated endogenous anti-oxidant hemoxygenase-1 (HO-1) expression, whereas pretreatment with Lucidone significantly up-regulates HO-1 expression followed by the transcriptional activation of NF-E2 related factor-2 (Nrf-2). Interestingly, the profound up-regulation of HO-1 and Nrf-2 were observed in only ethanol-challenged cells, which evidenced that Lucidone-induced induction of HO-/Nrf-2 were specific with oxidative stress. Thus, we concluded that Lucidone-mediated up-regulation of phase-II enzymes and HO-1 via Nrf-2 signaling pathway may provide a pivotal mechanism for its hepatoprotective action.

Lucidone from Lindera erythrocarpa Makino fruits suppresses adipogenesis in 3T3-L1 cells and attenuates obesity and consequent metabolic disorders in high-fat diet C57BL/6 mice.[Pubmed:23265843]

Phytomedicine. 2013 Mar 15;20(5):394-400.

Obesity is associated with an increased risk of development of numerous diseases including type 2 diabetes, hypertension, hyperlipidemia, and cardiovascular disease. In this study, we investigated the effects of Lucidone in vitro on gene expression during adipogenesis in 3T3-L1 cells and in vivo on high-fat diet induced obesity in C57BL/6 mice. Lucidone at 40 mumol/L suppressed adipogenesis in 3T3-L1 cells by reducing transcription levels of adipogenic genes, including PPARgamma, C/EBPalpha, LXR-alpha, LPL, aP2, GLUT4 and adiponectin. Five-week-old male C57BL/6 mice fed a high fat diet (60% energy from fat) supplemented with Lucidone at a dosage of 1250 mg/kg of diet for 12 weeks had reduced body and liver weight, reduced epididymal and perirenal adipose tissue, decreased food efficiency (percentage of weight gain divided by food intake), and lowered plasma cholesterol, triglyceride, glucose, and insulin levels. Dissection of adipose tissue from Lucidone-treated mice showed a reduction in the average fat-cell size and percentage of large adipocytes. These results provide evidence that dietary intake of Lucidone alleviates high fat diet-induced obesity in C57BL/6 mice and reveals the potential of Lucidone as a nutraceutical to prevent obesity and consequent metabolic disorders.

Lucidone Promotes the Cutaneous Wound Healing Process via Activation of the PI3K/AKT, Wnt/beta-catenin and NF-kappaB Signaling Pathways.[Pubmed:27816443]

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):151-168.

Lucidone, which comprises a naturally occurring cyclopentenedione, has been investigated for its in vitro and in vivo wound healing properties, and the underlying molecular signaling cascades in the wound healing mechanism have been elucidated. We demonstrated the cell-/dose-specific responses of Lucidone (0.5-8muM) on proliferation and migration/invasion of keratinocyte HaCaT and fibroblast Hs68 cells. In keratinocytes, Lucidone-induced nuclear translocation of beta-catenin was accompanied by increased transcriptional target genes, including c-Myc and cyclin-D1, through GSK3beta-dependent pathway. Correspondingly, Lucidone promoted the cell-cycle by increasing PCNA/CDK4 and decreasing p21/p27 expressions. Lucidone induced EMT through the downregulation of epithelial (E-cadherin/occludin) and upregulation of mesenchymal (vimentin/Twist/Snail) marker proteins. Activated MMP-9/-2 and uPA/uPAR as well as suppressed TIMP-1/-2 and PAI-1 expressions by Lucidone may promote the migration/invasion of keratinocytes. Notably, Lucidone activated NF-kappaB signaling via IKK-mediated-IkappaB degradation, and its inhibition abolished MMP-9 activation and keratinocyte migration. Inhibition of PI3K/AKT signaling impaired the Lucidone-induced proliferation/migration with corresponding suppression of beta-catenin/c-Myc/cyclin-D1 and NF-kappaB/MMP-9 expressions. Results indicate that Lucidone-induced PI3K/AKT signaling anchored the beta-catenin/NF-kappaB-mediated healing mechanism. beta-catenin knockdown substantially diminished Lucidone-induced keratinocyte migration. Furthermore, Lucidone increased endothelial cell proliferation/migration and triggered angiogenesis (MMP-9/uPA/ICAM-1). In macrophages, Lucidone-activated NF-kappaB-mediated inflammation (COX-2/iNOS/NO) and VEGF, which may contribute to the growth of keratinocytes/fibroblasts and endothelial cells. Punched wounds on mice were rapidly healed with the topical application of Lucidone (5mM) compared with control ointment-treated mice. Taken together, Lucidone accelerates wound healing through the cooperation of keratinocyte/fibroblast/endothelial cell growth and migration and macrophage inflammation via PI3K/AKT, Wnt/beta-catenin and NF-kappaB signaling cascade activation.

Anti-inflammatory effect of lucidone in mice via inhibition of NF-kappaB/MAP kinase pathway.[Pubmed:20079881]

Int Immunopharmacol. 2010 Apr;10(4):385-92.

Here, we investigated the anti-inflammatory activity of Lucidone, a phytocompound isolated from the fruits of Lindera erythrocarpa Makino, against lipopolysaccharide (LPS)-induced acute systemic inflammation in mice. Male ICR mice were injected intraperitoneally with LPS (5 microg/kg), and the effects of pretreatment with various concentrations of Lucidone (50-200 mg/kg) for 12h on the formation of nitric oxide (NO), prostaglandin-E(2) (PGE(2)) and tumor necrosis factor (TNF-alpha) were analyzed. Lucidone inhibited the production of NO, PGE(2) and TNF-alpha production in LPS-induced mice, and also induced mRNA and protein levels of inducible nitric oxide synthase (iNOS), and cyclooxigenase-2 (COX-2). The two common response elements of the iNOS and COX-2 genes are nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1). NF-kappaB nuclear translocation and DNA binding were inhibited by Lucidone in the LPS-induced mice. Moreover, Lucidone decreased the expression and phosphorylation of c-Jun N-terminal kinase (JNK) protein thereby causing the subsequent inhibition of AP-1 activity. Finally, our results indicated that Lucidone was able to block mitogen-activated protein kinases activity and its downstream signaling activation of NF-kappaB and AP-1. We thus conclude that Lucidone exerts its anti-inflammatory effects in mice by inhibiting the expression of pro-inflammatory factors and their related signaling pathways.

Lucidone protects human skin keratinocytes against free radical-induced oxidative damage and inflammation through the up-regulation of HO-1/Nrf2 antioxidant genes and down-regulation of NF-kappaB signaling pathway.[Pubmed:23712098]

Food Chem Toxicol. 2013 Sep;59:55-66.

We investigated the protective effects of Lucidone, a naturally occurring cyclopentenedione isolated from the fruits of Lindera erythrocarpa Makino, against free-radical and inflammation stimulator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress in human keratinocyte (HaCaT) cells, with the aim of revealing the possible mechanisms underlying the protective efficacy. Lucidone pretreatment (0.5-10 mug/mL) markedly increased HaCaT cell viability and suppressed AAPH-induced reactive oxygen species (ROS) generation, lipid peroxidation, and DNA damage. Notably, the antioxidant potential of Lucidone was directly correlated with the increased expression of an antioxidant gene, heme oxygenase 1 (HO-1), which was followed by the augmentation of the nuclear translocation and transcriptional activation of NF-E2-related factor-2 (Nrf2), with or without AAPH. Nrf2 knockdown diminished the protective effects of Lucidone. We also observed that Lucidone pretreatment inhibited AAPH-induced inflammatory chemokine prostaglandin E(2) (PGE(2)) production and the expression of cyclooxygenase-2 (COX-2) in HaCaT cells. Lucidone treatment also significantly inhibited AAPH-induced nuclear factor-kappaB (NF-kappaB) activation and suppressing the degradation of inhibitor-kappaB (I-kappaB). Furthermore, Lucidone significantly diminished AAPH-induced COX-2 expression through the down-regulation of the extracellular signal-regulated kinase (ERK) and p38 MAPK signaling pathways. Therefore, Lucidone may possess antioxidant and anti-inflammatory properties and may be useful for the prevention of free radical-induced skin damage.

Keywords:

Lucidone,19956-53-7,Natural Products, buy Lucidone , Lucidone supplier , purchase Lucidone , Lucidone cost , Lucidone manufacturer , order Lucidone , high purity Lucidone

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: