KolavenolCAS# 19941-83-4 |
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| Cas No. | 19941-83-4 | SDF | Download SDF |
| PubChem ID | 6442554 | Appearance | Powder |
| Formula | C20H34O | M.Wt | 290.49 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E)-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-en-1-ol | ||
| SMILES | CC1CCC2(C(C1(C)CCC(=CCO)C)CCC=C2C)C | ||
| Standard InChIKey | PQTMZYKTDFKGKV-UUMJGGROSA-N | ||
| Standard InChI | InChI=1S/C20H34O/c1-15(11-14-21)9-12-19(4)17(3)10-13-20(5)16(2)7-6-8-18(19)20/h7,11,17-18,21H,6,8-10,12-14H2,1-5H3/b15-11+/t17-,18-,19+,20+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Eupatorium adenophora
| Description | 1. Kolavenol shows a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis. |
| Targets | Antifection |
Kolavenol Dilution Calculator
Kolavenol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.4425 mL | 17.2123 mL | 34.4246 mL | 68.8492 mL | 86.0615 mL |
| 5 mM | 0.6885 mL | 3.4425 mL | 6.8849 mL | 13.7698 mL | 17.2123 mL |
| 10 mM | 0.3442 mL | 1.7212 mL | 3.4425 mL | 6.8849 mL | 8.6061 mL |
| 50 mM | 0.0688 mL | 0.3442 mL | 0.6885 mL | 1.377 mL | 1.7212 mL |
| 100 mM | 0.0344 mL | 0.1721 mL | 0.3442 mL | 0.6885 mL | 0.8606 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Bioassay-guided isolation of a diastereoisomer of kolavenol from Entada abyssinica active on Trypanosoma brucei rhodesiense.[Pubmed:9705008]
J Ethnopharmacol. 1998 Jul;61(3):179-83.
Bioassay-guided fractionation of the dichloromethane rootbark extract of Entada abyssinica (Leguminosae), a plant used by traditional healers in Uganda for the treatment of sleeping sickness, led to the isolation of a diastereoisomer of the clerodane type diterpene Kolavenol. This is the first report on this compound. It showed a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
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