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16-Oxocleroda-3,13E-dien-15-oic acid

CAS# 117620-72-1

16-Oxocleroda-3,13E-dien-15-oic acid

Catalog No. BCN7286----Order now to get a substantial discount!

Product Name & Size Price Stock
16-Oxocleroda-3,13E-dien-15-oic acid: 5mg $799 In Stock
16-Oxocleroda-3,13E-dien-15-oic acid: 10mg Please Inquire In Stock
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Quality Control of 16-Oxocleroda-3,13E-dien-15-oic acid

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Chemical structure

16-Oxocleroda-3,13E-dien-15-oic acid

3D structure

Chemical Properties of 16-Oxocleroda-3,13E-dien-15-oic acid

Cas No. 117620-72-1 SDF Download SDF
PubChem ID 38355304 Appearance Powder
Formula C20H30O3 M.Wt 318.45
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (E)-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-formylpent-2-enoic acid
SMILES CC1CCC2(C(C1(C)CCC(=CC(=O)O)C=O)CCC=C2C)C
Standard InChIKey LUZARHTWSOXFLP-HEZUFYQYSA-N
Standard InChI InChI=1S/C20H30O3/c1-14-6-5-7-17-19(14,3)10-8-15(2)20(17,4)11-9-16(13-21)12-18(22)23/h6,12-13,15,17H,5,7-11H2,1-4H3,(H,22,23)/b16-12+/t15-,17+,19+,20+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 16-Oxocleroda-3,13E-dien-15-oic acid

The stem barks of Polyalthia longifolia (Sonn) Thw. var. pendula.

Biological Activity of 16-Oxocleroda-3,13E-dien-15-oic acid

Description1. 16-Oxocleroda-3,13E-dien-15-oic acid shows antiplasmodial activity.
TargetsAntifection

16-Oxocleroda-3,13E-dien-15-oic acid Dilution Calculator

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16-Oxocleroda-3,13E-dien-15-oic acid Molarity Calculator

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Preparing Stock Solutions of 16-Oxocleroda-3,13E-dien-15-oic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1402 mL 15.7011 mL 31.4021 mL 62.8042 mL 78.5053 mL
5 mM 0.628 mL 3.1402 mL 6.2804 mL 12.5608 mL 15.7011 mL
10 mM 0.314 mL 1.5701 mL 3.1402 mL 6.2804 mL 7.8505 mL
50 mM 0.0628 mL 0.314 mL 0.628 mL 1.2561 mL 1.5701 mL
100 mM 0.0314 mL 0.157 mL 0.314 mL 0.628 mL 0.7851 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 16-Oxocleroda-3,13E-dien-15-oic acid

Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection.[Pubmed:25914039]

J Ethnopharmacol. 2015 Jul 1;169:176-82.

BACKGROUND: Plasmodium falciparum drug resistance is a major public health challenge in sub-Sahara Africa. Many people are now resorting to the use of herbs in managing malaria due to the increasing treatment failures with the conventional drugs. In this study the ethanolic extract of Polyalthia longifolia (Sonn) Thw. var. pendula, a variety fondly used in folklore medicine in Ghana was investigated for potential antimalarial drug development. METHOD: The ethanolic extract of P. longifolia (Sonn) Thw. var. pendula stem bark was screened against the multidrug resistant, K1 strain of P. falciparum by the parasite lactate dehydrogenase (pLDH) assay and a good antiplasmodial activity (IC50 22.04+/- 4.23microg/ml) was observed which led to further chromatographic analysis in search for actives. RESULTS: Bioassay guided fractionation of the extract yielded; three clerodane diterpenes [16-hydroxycleroda-3,13-dien-16,15-olide (1), 16-Oxocleroda-3,13E-dien-15-oic acid (2) and 3,16-dihydroxycleroda-4(18),13(14)Z-dien-15,16-olide (3)], a steroid [beta-stigmasterol (4)] and two alkaloids [darienine (5) and stepholidine (6)]. While compounds 4, 5 and 6 exhibited weak antiplasmodial activity (IC50 22-105microg/ml), the clerodane diterpenes exhibited significantly potent (p<0.005) blood schizonticidal activity (IC50: 3-6microg/ml). This is the first report of the antiplasmodial activity of compounds 2 and 3. In combination assay with chloroquine, compounds 1, 2, 3 and 5 antagonized the antiplasmodial activity of chloroquine while 4 and 6 demonstrated a synergistic action. CONCLUSION: The potent antiplasmodial activity of the extract of P. longifolia (Sonn) Thw. var. pendula and compounds therein strongly suggests its usefulness as an antimalarial agent and supports its inclusion or exploitation in formulations of herbal remedies for malaria in Ghana.

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