Home >> Research Area >>Neuroscience>>5-HT Receptor>> Agomelatine hydrochloride

Agomelatine hydrochloride

CAS# 1176316-99-6

Agomelatine hydrochloride

Catalog No. BCC4210----Order now to get a substantial discount!

Product Name & Size Price Stock
Agomelatine hydrochloride: 5mg $58 In Stock
Agomelatine hydrochloride: 10mg Please Inquire In Stock
Agomelatine hydrochloride: 20mg Please Inquire Please Inquire
Agomelatine hydrochloride: 50mg Please Inquire Please Inquire
Agomelatine hydrochloride: 100mg Please Inquire Please Inquire
Agomelatine hydrochloride: 200mg Please Inquire Please Inquire
Agomelatine hydrochloride: 500mg Please Inquire Please Inquire
Agomelatine hydrochloride: 1000mg Please Inquire Please Inquire
Related Products
  • AM580

    Catalog No.:BCC5373
    CAS No.:102121-60-8
  • AGN 194310

    Catalog No.:BCC5416
    CAS No.:229961-45-9
  • Palovarotene

    Catalog No.:BCC4185
    CAS No.:410528-02-8
  • AGN 205728

    Catalog No.:BCC5418
    CAS No.:859498-05-8
  • AGN 196996

    Catalog No.:BCC5417
    CAS No.:958295-17-5

Quality Control of Agomelatine hydrochloride

Number of papers citing our products

Chemical structure

Agomelatine hydrochloride

3D structure

Chemical Properties of Agomelatine hydrochloride

Cas No. 1176316-99-6 SDF Download SDF
PubChem ID 66980040 Appearance Powder
Formula C15H18ClNO2 M.Wt 279.76
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : ≥ 100 mg/mL (357.45 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide;hydrochloride
SMILES CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC.Cl
Standard InChIKey ZJVMEXOLMFNQPX-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H17NO2.ClH/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13;/h3-7,10H,8-9H2,1-2H3,(H,16,17);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Agomelatine hydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Agomelatine hydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Agomelatine hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5745 mL 17.8725 mL 35.7449 mL 71.4898 mL 89.3623 mL
5 mM 0.7149 mL 3.5745 mL 7.149 mL 14.298 mL 17.8725 mL
10 mM 0.3574 mL 1.7872 mL 3.5745 mL 7.149 mL 8.9362 mL
50 mM 0.0715 mL 0.3574 mL 0.7149 mL 1.4298 mL 1.7872 mL
100 mM 0.0357 mL 0.1787 mL 0.3574 mL 0.7149 mL 0.8936 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Agomelatine hydrochloride

Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6).

Featured Products
New Products
 

References on Agomelatine hydrochloride

Excessive sweating induced by interaction between agomelatine and duloxetine hydrochloride: case report and review of the literature.[Pubmed:25576334]

Wien Klin Wochenschr. 2015 Sep;127(17-18):703-6.

OBJECTIVE: In this case report, we describe a case in which the clinical pharmacy team was asked to provide recommendations on possible continued use of combination antidepressants in a 62-year-old Slovenian female patient with major depressive disorder following agomelatine and duloxetine hydrochloride-induced excessive sweating. When agomelatine was administered as an additional treatment, drug-induced excessive sweating was observed after a daily intake of 90 mg of duloxetine hydrochloride and 25 mg of agomelatine. After thorough discussion, it was decided not to rechallenge with agomelatine because of the serious adverse effect. After agomelatine discontinuation and switching to trazodone, symptoms immediately improved. DISCUSSION: Duloxetine hydrochloride-induced sweating has been reported frequently, but excessive sweating induced by agomelatine and duloxetine hydrochloride has not been reported in the literature. The adverse effect was determined by a clinical pharmacist using the Naranjo probability scale and was probably associated with agomelatine use (6 points) and possibly associated with duloxetine hydrochloride use (4 points). The exact mechanism for this adverse effect in this patient is not known, but we believe that a pharmacodynamic drug-drug interaction between agomelatine and duloxetine hydrochloride had occurred. CONCLUSION: Such a case has not yet been described in literature; however, an adverse effect associated with drug-drug interaction can occur, as this report clearly demonstrates. The benefits of this antidepressant combination need to be carefully balanced with the risks associated with its use. This case report also highlights the increased potential for adverse reactions when prescribing antidepressant combinations and importance of clinical pharmacists' involvement in the psychiatric patients' pharmacotherapy.

Description

Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.

Keywords:

Agomelatine hydrochloride,1176316-99-6,Natural Products,5-HT Receptor, buy Agomelatine hydrochloride , Agomelatine hydrochloride supplier , purchase Agomelatine hydrochloride , Agomelatine hydrochloride cost , Agomelatine hydrochloride manufacturer , order Agomelatine hydrochloride , high purity Agomelatine hydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: