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6-Hydroxymethylherniarin

CAS# 117597-79-2

6-Hydroxymethylherniarin

Catalog No. BCN3573----Order now to get a substantial discount!

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6-Hydroxymethylherniarin: 5mg Please Inquire In Stock
6-Hydroxymethylherniarin: 10mg Please Inquire In Stock
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Quality Control of 6-Hydroxymethylherniarin

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Chemical structure

6-Hydroxymethylherniarin

3D structure

Chemical Properties of 6-Hydroxymethylherniarin

Cas No. 117597-79-2 SDF Download SDF
PubChem ID 14212558 Appearance Powder.
Formula C11H10O4 M.Wt 206.2
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 6-(hydroxymethyl)-7-methoxychromen-2-one
SMILES COC1=C(C=C2C=CC(=O)OC2=C1)CO
Standard InChIKey ZYRLZLIMDGNMHZ-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 6-Hydroxymethylherniarin

The stem bark of Citrus funadoko

Biological Activity of 6-Hydroxymethylherniarin

DescriptionStandard reference

Protocol of 6-Hydroxymethylherniarin

Structure Identification
Phytochemistry.1994 May;36(1):217–219.

Stem bark coumarins of Citrus grandis.[Reference: WebLink]


METHODS AND RESULTS:
Two new coumarins, buntansin B and C, together with 10 known compounds, 6-Hydroxymethylherniarin, honyumine, limonin, buntanin, thamnosmonin, geibalansine, pubesinol acetonide, cis-isokhellactone, buntansin A and ulopterol, were isolated and characterized from the stem bark of Citrus grandis f. buntan. Their structures were elucidated by spectroscopic methods.

6-Hydroxymethylherniarin Dilution Calculator

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6-Hydroxymethylherniarin Molarity Calculator

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Preparing Stock Solutions of 6-Hydroxymethylherniarin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.8497 mL 24.2483 mL 48.4966 mL 96.9932 mL 121.2415 mL
5 mM 0.9699 mL 4.8497 mL 9.6993 mL 19.3986 mL 24.2483 mL
10 mM 0.485 mL 2.4248 mL 4.8497 mL 9.6993 mL 12.1242 mL
50 mM 0.097 mL 0.485 mL 0.9699 mL 1.9399 mL 2.4248 mL
100 mM 0.0485 mL 0.2425 mL 0.485 mL 0.9699 mL 1.2124 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 6-Hydroxymethylherniarin

Strong insecticidal potential of methanol extract of Ferulago trifida fruits against Anopheles stephensi as malaria vector.[Pubmed:30671757]

Environ Sci Pollut Res Int. 2019 Mar;26(8):7711-7717.

Many researchers have focused on controlling pest insects and vectors by natural products because of their low environmental pollution. The present study was conducted to evaluate the antioxidant and larvicidal activities of chloroform and methanol extracts of the leaves, fruits, roots, and isolated coumarin compounds (prantschimgin, oxypeucedanin, and 6-Hydroxymethylherniarin) of Ferulago trifida from the Apiaceae family against Anopheles stephensi as one of the main malaria vectors. For insecticidal evaluation, A. stephensi larvae were exposed to different concentrations of the extracts and pure compounds (0.625-1280 ppm) according to the WHO protocol. The mortality percentages were measured 24 h after treatment and lethal concentration values were calculated. In addition, radical scavenging activities of the mentioned extracts and compounds were measured by the DPPH method. The methanol extract of fruits showed potent insecticidal properties with LC50 and LC90 values of 2.94 and 18.12 ppm, respectively. The chloroform extracts of the fruits and leaves were the second and third extracts with larvicidal effects. Among pure compounds, only oxypeucedanin showed moderate toxicity against A. stephensi with LC50 and LC90 values of 116.54 and 346.41 ppm, respectively. The antioxidant activities of the methanol extracts of leaves and fruits were stronger than other extracts with IC50 values of 155.83 and 159.32 ppm, respectively. In conclusion, the methanol extract of F. trifida fruits can be used as a potent bio-insecticide in green control programs of mosquitoes, especially A. stephensi.

Bioactive coumarins from the roots and fruits of Ferulago trifida Boiss., an endemic species to Iran.[Pubmed:28954543]

Nat Prod Res. 2017 Sep 27:1-5.

Phytochemical analysis of the Ferulago trifida Boiss. from Apiaceae family led to the isolation and identification of suberosin (1), isoimperatorin (2), prantschimgin (3), oxypeucedanin (4), oxypeucedanin methanolate (5), suberenol (6), 6-Hydroxymethylherniarin (7), oxypeucedanin hydrate (8), ulopterol (9), bergapten (10), xanthotoxin (11), imperatorin (12) and grandivittin (13) from chloroform extracts of the roots (1-9) and fruits (1, 2, 8, 10-13) of this species. Oxypeucedanin methanolate and suberenol demonstrated a potent antioxidant power with 268.2 +/- 5.4 and 251.2 +/- 6.2 mmol FSE/100 g, respectively, compared by BHT (267.2 +/- 4.2 mmol FSE/100 g) in FRAP method. The potent antibacterial effects were found for oxypeucedanin methanolate on S. epidermidis (IZ; 26 mm, MIC; 250 mug mL(-1)) an oxypeucedanin hydrate on K. pneumoniae (IZ: 21 mm, MIC: 250 mug mL(-1)). Moreover, suberosin showed higher preferential toxicity against MDA-MB-23 cells (IC50: 0.21 mM, SI: 5.0), in comparison with tamoxifen (IC50: 0.012 mM, SI: 2.45) in MTT assay.

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