Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1726 | Calyxin B |
| 1. Calyxin B exhibits potent activity against human HT-1080 fibrosarcoma cells with an ED50 value of 0.69 microM. 2. A methylated product of calyxin A and an epimeric mixture of Calyxin B, showed greatly reduced activity suggesting that phenolic hydroxyl groups are involved in the inhibitory activity. | |
| BCN1727 | Brevilin A |
| Brevilin A is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs. Brevilin A shows antigiardial activity (IC50 = 16.1 μM) and is similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM). | |
| BCN1749 | Hypotaurine |
| 1. Hypotaurine is a precursor of taurine and an antioxidant, intracellular hypotaurine is mainly supplied to placental trophoblasts by transfer from extracellular fluid across the plasma membrane, and may play a role in cell protection by scavenging reactive oxygen species. 2. Hypotaurine and cysteine sulfinate have scavenging activity towards the carbonate radical anion. 3. Hypotaurine/taurine synthesis strongly inhibits cysteinesulfinate decarboxylase (pyridoxal 5'-phosphate-dependent enzyme) as well as cystathionine γ-lyase. 4. Hypotaurine and raffinose supplementation in semen extenders provide a protection of sperm parameters against cryopreservation injury. 5. Hypotaurine suppresses acute, inflammatory, and neuropathic pain, may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord, is a promising candidate for treating various pain states. | |
| BCN1756 | 2-Aminoethanol |
| 2-Aminoethanol (ethanolamine) can inhibit the GABA degrading enzyme GABA aminotransferase (GABA-T), it is a possible neuromodulator in the pigeon optic tectum. Strengthening of the antioxidant mechanisms by plant pretreatment with 2-aminoethanol could be helpful in the development of a broad tolerance to adverse stress conditions. | |
