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2-Aminoethanol

CAS# 141-43-5

2-Aminoethanol

Catalog No. BCN1756----Order now to get a substantial discount!

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Quality Control of 2-Aminoethanol

Number of papers citing our products

Chemical structure

2-Aminoethanol

3D structure

Chemical Properties of 2-Aminoethanol

Cas No. 141-43-5 SDF Download SDF
PubChem ID 700 Appearance Powder
Formula C2H7NO M.Wt 61.08
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-aminoethanol
SMILES C(CO)N
Standard InChIKey HZAXFHJVJLSVMW-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of 2-Aminoethanol

Description2-Aminoethanol (ethanolamine) can inhibit the GABA degrading enzyme GABA aminotransferase (GABA-T), it is a possible neuromodulator in the pigeon optic tectum. Strengthening of the antioxidant mechanisms by plant pretreatment with 2-aminoethanol could be helpful in the development of a broad tolerance to adverse stress conditions.
TargetsGABA Receptor
In vitro

Effect of 2-aminoethanol pretreatment on the antioxidant enzyme activity in Zea mays under oxidative stress[Reference: WebLink]

Russian Journal of Plant Physiology, 2011,58 (1):45-50.

Exposure of plants to stress may result in liberation of 2-Aminoethanol as an inducer of alarm reaction that activates cellular resistance and tolerance mechanisms.
METHODS AND RESULTS:
In the present study, the effect of exogenous 2-Aminoethanol on stimulation of tolerance mechanisms was investigated in maize (Zea mays L.) plants treated with the herbicide paraquat. Maize shoots were pretreated with 2-Aminoethanol. Two days later the shoots were treated with paraquat. Pretreatment with 2-Aminoethanol increased catalase and guaiacol peroxidase activities and cysteine content and decreased MDA and hydrogen peroxide content in maize plants treated with paraquat.
CONCLUSIONS:
Based on the results of this study, it can be suggested that strengthening of the antioxidant mechanisms by plant pretreatment with amino alcohol could be helpful in the development of a broad tolerance to adverse stress conditions.

In vivo

2-Aminoethanol as a possible neuromodulator in the pigeon optic tectum.[Pubmed: 7145226]

Neurosci Lett. 1982 Sep 20;32(1):53-8.


METHODS AND RESULTS:
A mass fragmentographic method was used for determination of low molecular weight compounds in perfusates collected in vivo in the pigeon optic tectum by a push-pull cannula technique. 2-Aminoethanol (ethanolamine) could be collected under resting conditions (5.6 +/- 0.09 pmol/min). Electrical stimulation of optic nerve induced a 2.3-fold increase of the tectal ethanolamine outflow whereas that of GABA was not affected. Ethanolamine applied iontophoretically to tectal neurons did not influence their spontaneous discharge; however, their glutamate-induced excitation as well as the GABA-induced depression were enhanced if ethanolamine was applied simultaneously.
CONCLUSIONS:
It is suggested that optic nerve stimulation exerts a neuromodulatory effect on tectal neurons.

Protocol of 2-Aminoethanol

Kinase Assay

Effect of 2-aminoethanol on the synthesis, binding, uptake and metabolism of GABA[Pubmed: 6320073]

Neurosci Lett. 1983 Dec 11;42(3):293-7.

2-Aminoethanol (ethanolamine) was studied for effects on neurochemical assays for GABA synthesis, receptor binding, uptake and metabolism in rat brain preparations.
METHODS AND RESULTS:
The effects of ethanolamine were compared with those of ethanolamine O-sulphate (EOS), an inhibitor of GABA degradation. Furthermore, the effect of both compounds was compared on GABA metabolism in rat brain in vivo. In vitro, ethanolamine and EOS had no significant effect on the GABA synthesizing enzyme glutamic decarboxylase (GAD) and GABA uptake, but both drugs proved virtually equipotent to inhibit the GABA degrading enzyme GABA aminotransferase (GABA-T). EOS was a relatively potent inhibitor of GABA receptor binding, whereas ethanolamine was not effective in this regard. Following systemic administration in rats, 50% inhibition of GABA-T in the brain was achieved by 500 mg/kg ethanolamine or 2000 mg/kg EOS, respectively. As a consequence of GABA-T inhibition, GABA levels increased significantly. GAD activity remained unchanged after both treatments.
CONCLUSIONS:
The present results suggest that the recently reported enhancement of functional effects of GABA by ethanolamine may relate, at least in part, to the inhibitory effect of the compound on GABA catabolism.

Structure Identification
J. Phys. Chem. A, 2002, 106 (4), pp 668–679

Hydrogen Bonding in Monomers and Dimers of 2-Aminoethanol[Reference: WebLink]


METHODS AND RESULTS:
Equilibrium structures of monomers and dimers of 2-Aminoethanol (AE) exhibiting different intramolecular and intermolecular hydrogen bonds between the OH and NH2 groups were optimized and analyzed in theoretical density functional B3LYP/6-311++G(2d,2p) calculations. Natural bond orbital (NBO) theory was applied to quantify the relative strength of these interactions and to account for their effect on stability, structural, and vibrational parameters of both monomers and dimers. It is shown that the charge transferred from the lone pair of the hydrogen bond acceptor to the antibonding orbital of the donor provides the substantial stabilizing component of the hydrogen bond. NBO energetic analysis demonstrates that the OH···N interaction is the strongest one for both monomers (intramolecular) and dimers (intermolecular). The intramolecular hydrogen bond in AE monomers is relatively weak, in part, because of its bent nature. The formation of a stronger and more linear intermolecular hydrogen bond between molecular units in AE dimers is accompanied by cooperative enhancement of the intramolecular hydrogen-bonding interactions.
CONCLUSIONS:
This effect is explained in terms of charge transfer among local bond orbitals and is relevant to the cooperative strengthening of hydrogen-bonding interactions in larger AE clusters.

2-Aminoethanol Dilution Calculator

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2-Aminoethanol Molarity Calculator

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Preparing Stock Solutions of 2-Aminoethanol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 16.372 mL 81.8599 mL 163.7197 mL 327.4394 mL 409.2993 mL
5 mM 3.2744 mL 16.372 mL 32.7439 mL 65.4879 mL 81.8599 mL
10 mM 1.6372 mL 8.186 mL 16.372 mL 32.7439 mL 40.9299 mL
50 mM 0.3274 mL 1.6372 mL 3.2744 mL 6.5488 mL 8.186 mL
100 mM 0.1637 mL 0.8186 mL 1.6372 mL 3.2744 mL 4.093 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2-Aminoethanol

2-Aminoethanol as a possible neuromodulator in the pigeon optic tectum.[Pubmed:7145226]

Neurosci Lett. 1982 Sep 20;32(1):53-8.

A mass fragmentographic method was used for determination of low molecular weight compounds in perfusates collected in vivo in the pigeon optic tectum by a push-pull cannula technique. 2-Aminoethanol (ethanolamine) could be collected under resting conditions (5.6 +/- 0.09 pmol/min). Electrical stimulation of optic nerve induced a 2.3-fold increase of the tectal ethanolamine outflow whereas that of GABA was not affected. Ethanolamine applied iontophoretically to tectal neurons did not influence their spontaneous discharge; however, their glutamate-induced excitation as well as the GABA-induced depression were enhanced if ethanolamine was applied simultaneously. It is suggested that optic nerve stimulation exerts a neuromodulatory effect on tectal neurons.

Effect of 2-aminoethanol on the synthesis, binding, uptake and metabolism of GABA.[Pubmed:6320073]

Neurosci Lett. 1983 Dec 11;42(3):293-7.

2-Aminoethanol (ethanolamine) was studied for effects on neurochemical assays for GABA synthesis, receptor binding, uptake and metabolism in rat brain preparations. The effects of ethanolamine were compared with those of ethanolamine O-sulphate (EOS), an inhibitor of GABA degradation. Furthermore, the effect of both compounds was compared on GABA metabolism in rat brain in vivo. In vitro, ethanolamine and EOS had no significant effect on the GABA synthesizing enzyme glutamic decarboxylase (GAD) and GABA uptake, but both drugs proved virtually equipotent to inhibit the GABA degrading enzyme GABA aminotransferase (GABA-T). EOS was a relatively potent inhibitor of GABA receptor binding, whereas ethanolamine was not effective in this regard. Following systemic administration in rats, 50% inhibition of GABA-T in the brain was achieved by 500 mg/kg ethanolamine or 2000 mg/kg EOS, respectively. As a consequence of GABA-T inhibition, GABA levels increased significantly. GAD activity remained unchanged after both treatments. The present results suggest that the recently reported enhancement of functional effects of GABA by ethanolamine may relate, at least in part, to the inhibitory effect of the compound on GABA catabolism.

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