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1-Hydroxymethyl-beta-carboline glucoside

CAS# 1408311-12-5

1-Hydroxymethyl-beta-carboline glucoside

2D Structure

Catalog No. BCN7026----Order now to get a substantial discount!

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Quality Control of 1-Hydroxymethyl-beta-carboline glucoside

3D structure

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1-Hydroxymethyl-beta-carboline glucoside

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Chemical Properties of 1-Hydroxymethyl-beta-carboline glucoside

Cas No. 1408311-12-5 SDF Download SDF
PubChem ID 125181813 Appearance Powder
Formula C18H20N2O6 M.Wt 360.36
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(9H-pyrido[3,4-b]indol-1-ylmethoxy)oxane-3,4,5-triol
SMILES C1=CC=C2C(=C1)C3=C(N2)C(=NC=C3)COC4C(C(C(C(O4)CO)O)O)O
Standard InChIKey UBEWCGDGCYXTEA-SOVHRIKKSA-N
Standard InChI InChI=1S/C18H20N2O6/c21-7-13-15(22)16(23)17(24)18(26-13)25-8-12-14-10(5-6-19-12)9-3-1-2-4-11(9)20-14/h1-6,13,15-18,20-24H,7-8H2/t13-,15-,16+,17-,18-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 1-Hydroxymethyl-beta-carboline glucoside

The plants of Picrasmae Ramulus et Folium.

Biological Activity of 1-Hydroxymethyl-beta-carboline glucoside

Description1-Hydroxymethyl-beta-carboline glucoside is a natural product from Picrasmae Ramulus et Folium.

Protocol of 1-Hydroxymethyl-beta-carboline glucoside

Structure Identification
Zhongguo Zhong Yao Za Zhi. 2014 May;39(9):1656-9.

Simultaneous determination of 4 alkaloids and a flavonoid in Picrasmae Ramulus et Folium by RP-HPLC.[Pubmed: 25095379]


METHODS AND RESULTS:
A RP-HPLC method was developed to evaluate the quality of Picrasmae Ramulus et Folium by simultaneous determination of five constituents including 1-hydroxymethyl-beta-carboline (1), 1-methoxicabony-beta-carboline (2), 4-methoxy-5-hydroxy-canthin-6-one (3), 4, 5-dimethoxy-canthin-6-one (4) and maackiain (5) in Picrasmae Ramulus et Folium. The samples were separated on a Kromasil RP-C18 (4.6 mm x 250 mm, 5 microm) column eluted with acetonitrile and 0.1% phosphoric acid as mobile phases in gradient mode. The detection wavelength was set at 254 nm. The calibration curves and linearity of the above five standards were determined as (1) Y = 6 525.6X + 37.25 (0.009-1.780 microg, r = 0.996 8), (2) Y = 3 662.3X + 41.55 (0.005-0.920 microg, r = 0.999 5), (3) Y = 3763.1X + 146.87 (0.015-3.060 microg, r = 0.999 0), (4) Y = 2 174.1X + 21.52 (0.003-0.620 microg, r = 0.999 5), and (5) Y = 276.25X + 7.65 (0.010-1.960 microg, r = 0.998 9), respectively.
CONCLUSIONS:
The method is simple and repeatable, and can be used for the quality assessment of Picrasmae Ramulus et Folium.

1-Hydroxymethyl-beta-carboline glucoside Dilution Calculator

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1-Hydroxymethyl-beta-carboline glucoside Molarity Calculator

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Preparing Stock Solutions of 1-Hydroxymethyl-beta-carboline glucoside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.775 mL 13.875 mL 27.75 mL 55.5001 mL 69.3751 mL
5 mM 0.555 mL 2.775 mL 5.55 mL 11.1 mL 13.875 mL
10 mM 0.2775 mL 1.3875 mL 2.775 mL 5.55 mL 6.9375 mL
50 mM 0.0555 mL 0.2775 mL 0.555 mL 1.11 mL 1.3875 mL
100 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.555 mL 0.6938 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 1-Hydroxymethyl-beta-carboline glucoside

[Simultaneous determination of 4 alkaloids and a flavonoid in Picrasmae Ramulus et Folium by RP-HPLC].[Pubmed:25095379]

Zhongguo Zhong Yao Za Zhi. 2014 May;39(9):1656-9.

A RP-HPLC method was developed to evaluate the quality of Picrasmae Ramulus et Folium by simultaneous determination of five constituents including 1-hydroxymethyl-beta-carboline (1), 1-methoxicabony-beta-carboline (2), 4-methoxy-5-hydroxy-canthin-6-one (3), 4, 5-dimethoxy-canthin-6-one (4) and maackiain (5) in Picrasmae Ramulus et Folium. The samples were separated on a Kromasil RP-C18 (4.6 mm x 250 mm, 5 microm) column eluted with acetonitrile and 0.1% phosphoric acid as mobile phases in gradient mode. The detection wavelength was set at 254 nm. The calibration curves and linearity of the above five standards were determined as (1) Y = 6 525.6X + 37.25 (0.009-1.780 microg, r = 0.996 8), (2) Y = 3 662.3X + 41.55 (0.005-0.920 microg, r = 0.999 5), (3) Y = 3763.1X + 146.87 (0.015-3.060 microg, r = 0.999 0), (4) Y = 2 174.1X + 21.52 (0.003-0.620 microg, r = 0.999 5), and (5) Y = 276.25X + 7.65 (0.010-1.960 microg, r = 0.998 9), respectively. The method is simple and repeatable, and can be used for the quality assessment of Picrasmae Ramulus et Folium.

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