Home >> Research Area >>Natural Products>>Diterpenoids>> 6-Hydroxy-5,6-dehydrosugiol

6-Hydroxy-5,6-dehydrosugiol

CAS# 140923-35-9

6-Hydroxy-5,6-dehydrosugiol

Catalog No. BCN3127----Order now to get a substantial discount!

Product Name & Size Price Stock
6-Hydroxy-5,6-dehydrosugiol: 5mg Please Inquire In Stock
6-Hydroxy-5,6-dehydrosugiol: 10mg Please Inquire In Stock
6-Hydroxy-5,6-dehydrosugiol: 20mg Please Inquire Please Inquire
6-Hydroxy-5,6-dehydrosugiol: 50mg Please Inquire Please Inquire
6-Hydroxy-5,6-dehydrosugiol: 100mg Please Inquire Please Inquire
6-Hydroxy-5,6-dehydrosugiol: 200mg Please Inquire Please Inquire
6-Hydroxy-5,6-dehydrosugiol: 500mg Please Inquire Please Inquire
6-Hydroxy-5,6-dehydrosugiol: 1000mg Please Inquire Please Inquire

Quality Control of 6-Hydroxy-5,6-dehydrosugiol

Number of papers citing our products

Chemical structure

6-Hydroxy-5,6-dehydrosugiol

3D structure

Chemical Properties of 6-Hydroxy-5,6-dehydrosugiol

Cas No. 140923-35-9 SDF Download SDF
PubChem ID 3009284 Appearance Powder
Formula C20H26O3 M.Wt 314.4
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (4aR)-6,10-dihydroxy-1,1,4a-trimethyl-7-propan-2-yl-3,4-dihydro-2H-phenanthren-9-one
SMILES CC(C)C1=C(C=C2C(=C1)C(=O)C(=C3C2(CCCC3(C)C)C)O)O
Standard InChIKey XLUHSPYVUOVWRM-HXUWFJFHSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of 6-Hydroxy-5,6-dehydrosugiol

Description1. 6-Hydroxy-5,6-dehydrosugiol is a potent androgen receptor antagonist in prostate cancer cells, it has potential for use in chemoprevention and chemotherapy of prostate cancers.
TargetsAndrogen Receptor | Caspase | p53 | PARP | CDK

6-Hydroxy-5,6-dehydrosugiol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

6-Hydroxy-5,6-dehydrosugiol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 6-Hydroxy-5,6-dehydrosugiol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1807 mL 15.9033 mL 31.8066 mL 63.6132 mL 79.5165 mL
5 mM 0.6361 mL 3.1807 mL 6.3613 mL 12.7226 mL 15.9033 mL
10 mM 0.3181 mL 1.5903 mL 3.1807 mL 6.3613 mL 7.9517 mL
50 mM 0.0636 mL 0.3181 mL 0.6361 mL 1.2723 mL 1.5903 mL
100 mM 0.0318 mL 0.159 mL 0.3181 mL 0.6361 mL 0.7952 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on 6-Hydroxy-5,6-dehydrosugiol

A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis.[Pubmed:18701487]

Cancer Res. 2008 Aug 15;68(16):6634-42.

Androgen receptor (AR) is the main therapeutic target for treatment of metastatic prostate cancers (PCa). As recurrent tumors restore AR activity independent of hormones, new therapies that abolish AR activity have been sought to prevent or delay the emergence of ablation-resistant disease. Here, we report that a novel abietane diterpene, 6-Hydroxy-5,6-dehydrosugiol (HDHS), isolated from the stem bark of Cryptomeria japonica, was a potent AR antagonist in PCa cells. HDHS treatment of androgen-dependent LNCaP and androgen-responsive 22Rv1 cells induced apoptosis as shown by nucleosome release, activation of caspase-3 and caspase-7, and cleavage of poly(ADP-ribose) polymerase accompanied with concomitant up-regulation of tumor suppressor p53. HDHS also decreased the protein expression of cyclins (D1 and E), cyclin-dependent kinases (CDK2, CDK4, and CDK6), and retinoblastoma phosphorylation in PCa cells, which suggest cell cycle arrest in the G(1) phase. Oral administration of HDHS at 0.5 and 2.5 mg/kg once daily for 24 days to 22Rv1 PCa xenografted mice suppressed tumor growth by 22% and 39%, respectively, in association with decreased proliferation and increased apoptosis in tumor cells, which further correlated with increased levels of HDHS in plasma and tumors. Overall, our data suggest that HDHS has potential for use in chemoprevention and chemotherapy of PCa.

Keywords:

6-Hydroxy-5,6-dehydrosugiol,140923-35-9,Natural Products, buy 6-Hydroxy-5,6-dehydrosugiol , 6-Hydroxy-5,6-dehydrosugiol supplier , purchase 6-Hydroxy-5,6-dehydrosugiol , 6-Hydroxy-5,6-dehydrosugiol cost , 6-Hydroxy-5,6-dehydrosugiol manufacturer , order 6-Hydroxy-5,6-dehydrosugiol , high purity 6-Hydroxy-5,6-dehydrosugiol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: