Products with Nematicidal bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1266 | N-Methylcytisine |
| N-Methylcytisine's nicotinic receptors have high affinity (KD = 50 nM)to nAChR from squid optical ganglia, N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system. (−)-N-methylcytisine and (−)-anagyrine have nematicidal activity against pine wood nematodes. | |
| BCN1550 | 3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol |
| 1. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol, one toxic terpenoid from raw Gansui. 2. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships . 3. 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol show the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball. 4. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol induces the cytotoxicity of intestinal epithelial cells of rats (IEC-6 cells) depends on induction of cell apoptosis via mitochondrial pathway and cell cycle arrest. 5. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol, kansuinine B and kansuinine A can markedly promote SPL proliferation and NO production by PMphi at concentrations from 0.78 to 12.50 microg/mL, hence the they are believed to be important proinflammatory components of the roots of E. kansui. | |
| BCN1650 | Camaric acid |
| 1. Camaric acid, lantanilic acid, and oleanolic acid possess nematicidal activity, they exhibit 95%, 98% and 70% mortality respectively against root-knot nematode Meloidogyne incognita at 0.5% concentration. 2. Camaric acid shows antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus with IC50 values 8.74 and 8.09 uM, respectively, it also shows moderate antileishmanial activity and highly potent antitrypanosomal activity. 3. Camaric acid shows anticancer activity. 4. Camaric acid shows significant topical anti-inflammatory activity with IC50 value of 0.67 mg/ear in the assay of TPA mouse ear oedema model. | |
| BCN2162 | alpha-Chaconine |
| 1. Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. 2. The cytotoxic effects of α-Solanine and alpha-Chaconine were observed immediately after incubation and were constant after 30min, suggesting that rapid damage of plasma membrane causes the lethal disorder of metabolism. | |
