Products with Nephrotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3362 | Alisol O |
| Standard reference | |
| BCN3458 | Alisol C |
| 1. Alisol C can improve glucose uptake in Hep G2 cells, it may be one of the therapeutic material basis in hypoglycemic activities in A. orientalis. 2. Alisol C,16,23-oxido-alisol B and alisol O in Zexie may cause nephrotoxicity. | |
| BCN5080 | Strictosamide |
| 1. Strictosamide may have important effects on inflammation and inflammatory pain. 2. Strictosamide is slightly toxic to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity. 3. Strictosamide has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain. 4. Strictosamide possesses antibacterial and antiviral activities. | |
| BCN6262 | Aristolochic acid A |
| Aristolochic acid A is a potent nephrotoxin, which strongly induced toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis. | |
| BCN6271 | Colchicine |
| Colchicine is a tubulin inhibitor, and a microtubule polymerization inhibitor with an IC50 of 3 nM. It prevents amyloidosis in our high-risk population and that it can prevent additional deterioration of renal function in patients with amyloidosis who have proteinuria but not the nephrotic syndrome. Colchicine has anti-mitotic activity, it can be used to treat familial mediterranean fever, and as a lead compound for the generation of potent anti-cancer drugs. | |
