Products with Nephrotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2383 | Gardenoside |
| Gardenoside has hepatoprotective, pain‑relieving, and anti-mastitis effects. it may be a potential therapeutic herb against NASH by suppressed supernatant inflammatory cytokine production and intracellular NFkB activity. Gardenoside may be considered potential drug candidates that target P2X3 and P2X7 purine receptors. | |
| BCN2456 | Aristololactam I |
| Aristololactam I (AL-I), the main metabolite of aristolochic acid I (AA-I), it can lead to renal damage, the cytotoxic potency of Aristololactam I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase 3-dependent pathway. | |
| BCN2564 | Amphotericin B |
| 1. Amphotericin B is an antifungal agent. 2. Amphotericin B inhibits the A. actinomycetemcomitans-induced production of prostaglandin E2. 3. Amphotericin B can regulate inflammatory cytokines in host cells and regulate inflammatory responses in HGEC. 4. Amphotericin B inhibits the A. actinomycetemcomitans-induced phosphorylation of ERK and p38 MAP kinase. 5. The inhibition of the PKA signaling pathway can aid in reducing the degree of nephrotoxicity caused by Amphotericin B. 6. Treatment with Amphotericin B, particularly in combination with MCSF, increased the number of oligodendrocyte precursor cells and promoted remyelination within lesions. | |
| BCN2658 | Aristolochic acid C |
| 1. Aristolochic acid(AA) is a powerful nephrotoxic and carcinogenic substance with an extremely short latency period, not only in animals but also in humans, in particular, the highly similar metabolic pathway of activation and resultant DNA adducts of AA allows the extrapolation of carcinogenesis data from laboratory animals to the human situation; therefore, all products containing botanicals known to or suspected of containing AA should be banned from the market world wide. | |
| BCN2902 | Aristolochic acid D |
| 1. Chinese-herb nephropathy (CHN) is a rapidly progressive renal fibrosis associated with the intake of a Chinese herb (Aristolochia fangchi) containing nephrotoxic and carcinogenic aristolochic acids . | |
