Products with Pro-osteoblastogenesis bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5049 | Cytochalasin D |
| 1. Cytochalasin D-induced extension of neurite-like processes might correlate with enhanced accumulation of PrPres. 2. Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. 3. Cytochalasin D inhibits CT26 tumor growth potentially through inhibition of cell proliferation, induction of cell apoptosis and suppression of tumor angiogenesis. 4. Cytochalasin D stimulates the expression of TF in B16 melanoma cells, activating both coagulation-dependent and -independent pathways via binding to FVIIa, eventually promoting lung metastasis. 5. Cytochalasin D inhibits smooth muscle contraction by directly inhibiting contractile apparatus. 6. Cytochalasin D is an inhibitor of microfilament-dependent phagocytosis, it (0.5 or 1.0 micrograms/ml) can inhibit intracellular multiplication of L. pneumophila in U937 monocytes. 7. Cytochalasin D may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. | |
| BCN5061 | Serratenediol |
| 1. Serratenediol has significant and dose-dependent growth inhibitory effects on HL-60 cells via regulating the ratio of Bax/Bcl-xL. 2. Serratenediol can promote the proliferation rate,alkaline phosphate(ALP) activity and some osteogenic gene expression of osteoblasts. 3. Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. | |
| BCN5232 | Isobavachin |
| Isobavachin can stimulate osteoblasts proliferation and differentiation; it also can facilitate mouse embryonic stem cells differentiating into neuronal cells, the mechanism involved protein prenylation and, subsequently, phos-ERK activation and the phos-p38 off pathway. Isobavachin possesses estrogen-like activity in MCF-7/BOS cells, it can significantly stimulate the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin has cytotoxic effects on H4IIE hepatoma and metabolically poorly active C6 glioma cells. | |
| BCN5249 | Cajanin |
| 1. Cajanin has strong mitogenic as well as differentiation-promoting effects on osteoblasts that involved subsequent activation of MEK-Erk and Akt pathways. 2. Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT. 3. Cajanin can significantly improve basal glucose uptake in HepG2 cells, its improving effect is concentration dependent, it exhibits effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug. | |
| BCN5348 | Maohuoside A |
| 1. Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways. | |
