Products with Skin-whitening agents bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5609 | Rhododendrol |
| 1. (+)-Rhododendrol and epi-rhododendrin have anti-inflammatory effect, they can suppress the NO production by activated macrophages in vivo. 2. Rhododendrol is an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, it can competitively inhibit mushroom tyrosinase and serve as a good substrate, while it also shows cytotoxicity against cultured human melanocytes at high concentrations sufficient for inhibiting tyrosinase. | |
| BCN5921 | 8-Gingerol |
| 8-Gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb, it has anti-oxidant, anti-inflammatory, immunosuppressive, and skin-whitening activities. It suppresses cellular tyrosinase activity and decrease melanin content, inhibits the expression of MC1R, MITF, tyrosinase, TRP1 and TRP2, decreases intracellular RS and ROS levels in B16F10 and B16F1 cells, inhibits melanogenesis by down-regulation of MAPK, PKA signaling pathway. | |
| BCN6219 | Sweroside |
| Sweroside possesses wound healing, cytoprotective, skin-whitening , anti-osteoporotic , and hepatoprotective effect. It can inhibit potent melanogenesis in melan-a cells at 300uM without cytotoxicity, also decreases tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells. It also shows insulin-mimicking effects on the regulation of Pck1 expression. | |
| BCN6307 | Arbutin |
| Arbutin is a tyrosinase inhibitor with an IC50 of 1.09 mM, which has gastroprotective, whitening, anti- age, anti-oxidant , anti-inflammatory, a depigmenting effects and UVB/ UVC filter. Arbutin has mutagenicity in mammalian cells after activation by human intestinal bacteria. | |
| BCN6543 | Kojic acid |
| 1. Kojic acid exhibits a competitive inhibition for the oxidation of chlorogenic acid and catechol by potato polyphenol oxidase (PPO) and of 4-methylcatechol and chlorogenic acid by apple PPO. 2. Kojic acid has significant tyrosinase inhibitory activity. 3. Kojic acid has been used as a food additive for preventing enzymatic browning of crustaceans and as a cosmetic agent for skin whitening. 4. Kojic acid exhibits concentration-dependent scavenging activity on DPPH possessing strong antioxidant activity, it can reduce the mortality induced by gamma irradiation. | |
