Products with Vascular tone regulation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1061 | Formononetin |
| Formononetin is a phytoestrogen, could be used in postmenopausal osteoporosis. It has antitumorigenic effects, suppressed the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis; it also exhibits antiviral activities against some members of Picornaviridae, could inhibit EV71-induced COX-2 expression and PGE2 production via MAPKs pathway including ERK, p38 and JNK. | |
| BCN5259 | Hypophyllanthin |
| 1. Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. 2. Hypophyllanthin can modulate the vascular tension via the endothelium-independent mechanisms. 3. Hypophyllanthin can directly inhibit P-gp activity and does not interfere with MRP2 activity, it may reversibly inhibit P-gp function. 4. Hypophyllanthin offers a promising means for treatment of chronic muscle pain. 5. Hypophyllanthin has estrogenic properties against carbofuran induced toxicity in female rats. | |
| BCN5848 | Phyllanthin |
| 1. Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp. | |
| BCN5952 | Sodium Danshensu |
| Sodium danshensu (SDSS), the sodium salt of danshensu (DSS), has the neuroprotective effect against cerebral I/R injury, and the potential mechanism might to inhibition of apoptosis through activating the PI3K/Akt signal pathway. SDSS has a protective effect against the genotoxicity of cigarette smoke，it shows a biphasic effects on vessel tension, while low dosage of sodium danshensu produces small contraction possibly through transient enhancement of Ca(2+) influx, high dosage produces significant vasodilation mainly through promoting the opening of non-selective K(+) channels and small-conductance calcium-sensitive K(+) channels in the vascular smooth muscle cells. | |
