Products with Vasoprotective bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2167 | Fingolimod hydrochloride |
| Fingolimod hydrochloride is an oral sphingosine-1-phosphate analogue that was approved by the FDA in 2010 for the treatment of relapsing forms of multiple sclerosis (MS). Fingolimod hydrochloride , a pak1 activator, can inhibit astemizole-induced hypertrophy and cytotoxicity in H9c2 cells, suggests that antihistamine-induced cardiac adverse effects are associated with pak1 expression and function.The gels containing 0.50% fingolimod hydrochloride (FNGL) and FNGL 0.50% plus 6% colloidal oatmeal have potential for the treatment of atopic dermatitis (AD). | |
| BCN2369 | Salvianolic acid D |
| 1. Salvianolic acid and notoginseng triterpenes can promote EA-hy926 and expression of protein, have protective effects on angiogenesis in EA-hy926 cells in vitro. | |
| BCN2569 | Simvastatin |
| Simvastatin is an FDA-approved cholesterol-lowering medication, it possesses potent anti-inflammatory property and has potent benefits on endothelial and smooth muscle cell-mediated vasomotor responses. Simvastatin rescues Aβ-mediated cerebrovascular and cognitive deficits. Simvastatin reduces burn-induced splenic apoptosis via downregulation of the TNF-α/NF-κB pathway, it induces p65 instability leads to MMP-9 down-regulation in leukemia cells, while it induces JNK1/c-Jun/ATF-2 activation maintains the MMP-2 expression underlying p65 down-regulation. | |
| BCN2609 | Vinpocetine |
| Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. Vinpocetine can attenuate neointimal formation in diabetic rats and inhibit HG-induced VSMCs proliferation, chemokinesis and apoptotic resistance by preventing ROS activation and affecting MAPK, PI3K/Akt, and NF-κB signaling.Vinpocetine has anti-inflammatory activity, can treat inflammation and pain induced by a gram-negative bacterial component by targeting NF-κB activation and NF-κB-related cytokine production in macrophages. | |
| BCN3015 | Delphinidin chloride |
| 1. Delphinidin chloride is a dietary antioxidant. 2. Delphinidin is a naturally occurring inhibitor of vascular endothelial growth factor receptors, possesses important antiangiogenic properties that may be helpful for the prevention and treatment of cancer. 3. Delphinidin shows inhibitory effect on fibrosarcoma invasiveness, has the potential to act directly against tumour cells as well as to interfere with key tumour-host interactions, may represent a novel lead compound for the development of chemopreventative and chemotherapeutic intervention strategies. | |
