Natural Products from Actinostemma lobatum
Natural Products Isolated from Actinostemma lobatum
BioCrick provides high-purity natural products and bioactive compounds isolated and purified from natural sources for scientific research.
- Natural product compounds selected from diverse chemical and biological sources.
- Broad structural diversity and coverage of biological activities.
- Product activity information can be supported by published literature, patents and research reports.
- Natural products can be selected according to source, target, activity and disease research interests.
- Compounds should be stored according to the product specifications after receipt.
Natural Products from Actinostemma lobatum
7 natural product s associated with Actinostemma lobatum
| Catalog No. | Product Name | CAS Number | COA |
|---|---|---|---|
| BCN4537 |
3,4-Dihydroxybenzoic acid
|
99-50-3 | COA |
| BCN5816 |
4-Hydroxybenzaldehyde
|
123-08-0 | COA |
| BCN4546 |
4-Hydroxybenzoic acid
|
99-96-7 | COA |
| BCN2300 |
Cucurbitacin E
|
18444-66-1 | COA |
| BCN6049 |
Quercetin
|
117-39-5 | COA |
| BCN5665 |
Quercitrin
|
522-12-3 | COA |
| BCN2955 |
Tubeimoside II
|
115810-12-3 | COA |
References
A new cyclic bisdesmoside from Actinostemma lobatum Maxim.[Pubmed: 26062306]
A new cyclic bisdesmoside treterpene saponin, lobatoside N (1), together with four known triterpenoids, was isolated from the herb of Actinostemma lobatum Maxim. Structures were established by means of extensive spectral data analysis. Furthermore, the cytotoxic activities of the identified compounds were evaluated using HCT-116, HT-29, MCF-7 and A549 human cancer cell lines. As a result, compounds 1-5 showed significant cytotoxicities in a dose-dependent manner against the cell lines tested. Especially, compound 5 exhibited stronger activities, with IC50 value of 0.88 μM and 0.98 μM, than that of the positive control drug (Cis-platinum) against HT-29 and A549 cell lines.
Cyclic bisdesmosides from Actinostemma lobatum MAXIM (Cucurbitaceae) and their in vitro cytotoxicity.[Pubmed: 22056664]
Two new cyclic bisdesmosides elucidated as lobatoside L (1) and lobatoside M (2) and four known cyclic bisdesmosides (3-6) were isolated from Actinostemma lobatum MAXIM (Cucurbitaceae). Their structures were determined on the basis of spectroscopic analyses including IR, HR-FAB-MS, TOCSY, 1D- and 2D-NMR experiments and chemical reactions. The inhibitory effects of the six compounds on human cancer cell growth (including esophageal squamous carcinoma cell line ECA109, lung cancer cell line A549 and gastric cancer cell line MGC-803) were determined using the MTT assay. The results revealed that the six compounds exhibited cytotoxicity against all the cell lines tested, and compounds 1, 3 and 5 showed significant activities in a dose dependent manner against all the cell lines, especially for compound 1 and 5, the IC(50) values for ECA-109 cells were 8.25 μM and 3.71 μM. The results demonstrated that compounds 1 and 5's activities are 2- and 4-fold that of cisplatin.
Blockade of glycoprotein IIb/IIIa mediates the antithrombotic activity of butanol fraction of Actinostemma lobatum Maxim.[Pubmed: 18243609]
Actinostemma lobatum Maxim, a wildlife plant of Cucurbitaceae family, has been utilized for the prevention or treatment of cardiovascular diseases as a folk remedy in Korea. However, its scientific evidence remains unclear. Thus, in the present study, we examined the effects of butanol fraction of Actinostemma lobatum Maxim (BFALM) on the in vitro and in vivo antithrombotic activity and possible mechanisms were elucidated for the first time.