Hot Natural Products & Bioactive Compounds

Licochalcone D has anti-inflammatory, and anti-allergic activities, it shows suppression ability of nitric oxide (NO) production, it also suppresses degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. Licochalcone D has cardioprotective potential against myocardial ischemia/reperfusion injury in langendorff-perfused rat hearts. It may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion.

1. Licochalcone E is a potential LXRβ agonist.
2. Licochalcone E may be used for the treatment of hepatotoxicity, and primarily exhibits its protective role through a PPARγ/NF-κB-mediated pathway.
3. Licochalcone E exhibits potential chemopreventive effects and warrants further developed as a chemotherapeutic agent against oral cancer.
4. Licochalcone E exhibits potent anti-inflammatory property in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage models.
5. Licochalcone E suppresses lung metastasis in the 4T1 mammary orthotopic cancer model.
6. Licochalcone E shows potent antimicrobial property against Staphylococcus aureus.
7. Licochalcone E is a potential activator of the Nrf2/ARE-dependent pathway and is therapeutically relevant not only to oxidative-stress-related neurodegeneration but also inflammatory responses of microglial cells both in vitro and in vivo.
8. Licochalcone E has an antidiabetic effect, it increases the levels of PPARγ expression, at least in part, via the stimulation of Akt signals and functions as a PPARγ partial agonist.
9. Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B.
10. Licochalcone E shows cytotoxicity against the human tumor cell lines.

1. Conicasterol displays marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with the IC50 value of 6.23 ug/mL.

1. Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties.
2. Clematichinenoside AR has antioxidant and anti-inflammatory cardioprotection effects against MI/R injury, it protects H9c2 cardiomyocytes against H/R-induced apoptosis through mitochondrial-mediated apoptotic signaling pathway.
3. Clematichinenoside AR could be used as an effective neuroprotective agent to protect against ischemic stroke after cerebral I/R injury through regulating both ERK1/2 and cPKC mediated p90RSK/CREB apoptotic pathways.
4. Clematichinenoside AR has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α associated with collagen-induced arthritis.

1. Beta-Hydroxyisovalerylshikonin can significantly decrease viability of HCT116 cells (IC50 values of 30.9 ug/mL).
2. Beta-Hydroxyisovalerylshikonin has antiinflammatory and antitumor effects.
3. Beta-Hydroxyisovalerylshikonin has anti-adipogenic effect, it activated AMPK, which was followed by the downregulation of mature SREBP‑1c and fat-forming enzymes, leading to the inhibition of adipogenesis.
4. Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines.

1. Isorhamnetin 3-O-robinobioside has a great antioxidant and antigenotoxic potential on human chronic myelogenous leukemia cell line K562.

1. 3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).

1. Clitorin has free radical scavenging property.
2. Clitorin shows significant interactions with CD38, it may have anti-hyperglycemic potential .