ConicasterolCAS# 76758-18-4 |
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| Cas No. | 76758-18-4 | SDF | Download SDF |
| PubChem ID | 21670674 | Appearance | Powder |
| Formula | C29H48O | M.Wt | 412.70 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3S,5R,9R,10R,13R,17R)-17-[(2R,5R)-5,6-dimethylheptan-2-yl]-10,13-dimethyl-4-methylidene-1,2,3,5,6,7,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ol | ||
| SMILES | CC(C)C(C)CCC(C)C1CCC2=C3CCC4C(=C)C(CCC4(C3CCC12C)C)O | ||
| Standard InChIKey | BDIHZBORJCSTHA-TYRJJJPYSA-N | ||
| Standard InChI | InChI=1S/C29H48O/c1-18(2)19(3)8-9-20(4)23-12-13-25-22-10-11-24-21(5)27(30)15-17-29(24,7)26(22)14-16-28(23,25)6/h18-20,23-24,26-27,30H,5,8-17H2,1-4,6-7H3/t19-,20-,23-,24+,26+,27+,28-,29+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
From Theonella conica
| Description | 1. Conicasterol displays marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with the IC50 value of 6.23 ug/mL. |
Conicasterol Dilution Calculator
Conicasterol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4231 mL | 12.1153 mL | 24.2307 mL | 48.4614 mL | 60.5767 mL |
| 5 mM | 0.4846 mL | 2.4231 mL | 4.8461 mL | 9.6923 mL | 12.1153 mL |
| 10 mM | 0.2423 mL | 1.2115 mL | 2.4231 mL | 4.8461 mL | 6.0577 mL |
| 50 mM | 0.0485 mL | 0.2423 mL | 0.4846 mL | 0.9692 mL | 1.2115 mL |
| 100 mM | 0.0242 mL | 0.1212 mL | 0.2423 mL | 0.4846 mL | 0.6058 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Mirabolides A and B; New Cytotoxic Glycerides from the Red Sea Sponge Theonella mirabilis.[Pubmed:27548191]
Mar Drugs. 2016 Aug 18;14(8). pii: md14080155.
As a part of our continuing work to find out bioactive lead molecules from marine invertebrates, the CHCl(3) fraction of the organic extract of the Red Sea sponge Theonella mirabilis showed cytotoxic activity in our primary screen. Bioassay-guided purification of the active fractions of the sponge's extract resulted in the isolation of two new glycerides, mirabolides A and B (1 and 2), together with the reported 4-methylene sterols, Conicasterol (3) and swinhosterol B (4). The structures of the compounds were assigned by interpretation of their 1D ((1)H, (13)C), 2D (COSY, HSQC, HMBC, ROESY) NMR spectral data and high-resolution mass determinations. Compounds 1-4 displayed marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with IC50 values of 16.4, 5.18, 6.23 and 3.0 mug/mL, respectively, compared to 5.4 mug/mL observed by doxorubicin as reference drug.
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