Home >> Research Area >>Natural Products>>Lignans>> Magnaldehyde B

Magnaldehyde B

CAS# 92829-72-6

Magnaldehyde B

Catalog No. BCN8677----Order now to get a substantial discount!

Product Name & Size Price Stock
Magnaldehyde B: 5mg Please Inquire In Stock
Magnaldehyde B: 10mg Please Inquire In Stock
Magnaldehyde B: 20mg Please Inquire Please Inquire
Magnaldehyde B: 50mg Please Inquire Please Inquire
Magnaldehyde B: 100mg Please Inquire Please Inquire
Magnaldehyde B: 200mg Please Inquire Please Inquire
Magnaldehyde B: 500mg Please Inquire Please Inquire
Magnaldehyde B: 1000mg Please Inquire Please Inquire

Quality Control of Magnaldehyde B

Number of papers citing our products

Chemical structure

Magnaldehyde B

3D structure

Chemical Properties of Magnaldehyde B

Cas No. 92829-72-6 SDF Download SDF
PubChem ID 5320888 Appearance Powder
Formula C18H16O3 M.Wt 280.3
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (E)-3-[4-hydroxy-3-(2-hydroxy-5-prop-2-enylphenyl)phenyl]prop-2-enal
SMILES C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)C=CC=O)O
Standard InChIKey CWLSQIXOLLQBDC-HWKANZROSA-N
Standard InChI InChI=1S/C18H16O3/c1-2-4-13-6-8-17(20)15(11-13)16-12-14(5-3-10-19)7-9-18(16)21/h2-3,5-12,20-21H,1,4H2/b5-3+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Magnaldehyde B

The barks of Magnolia officinalis

Biological Activity of Magnaldehyde B

Description1. Magnaldehyde B is a natural lipase inhibitor(IC50= 96.96 uM). 2. Magnaldehyde B can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent.

Magnaldehyde B Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Magnaldehyde B Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Magnaldehyde B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5676 mL 17.838 mL 35.6761 mL 71.3521 mL 89.1902 mL
5 mM 0.7135 mL 3.5676 mL 7.1352 mL 14.2704 mL 17.838 mL
10 mM 0.3568 mL 1.7838 mL 3.5676 mL 7.1352 mL 8.919 mL
50 mM 0.0714 mL 0.3568 mL 0.7135 mL 1.427 mL 1.7838 mL
100 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.7135 mL 0.8919 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Magnaldehyde B

Fabrication of enzyme-immobilized halloysite nanotubes for affinity enrichment of lipase inhibitors from complex mixtures.[Pubmed:25798866]

J Chromatogr A. 2015 May 1;1392:20-7.

Lipase is the key enzyme for catalyzing triglyceride hydrolysis in vivo, and lipase inhibitors have been used in the management of obesity. We present the first report on the use of lipase-adsorbed halloysite nanotubes as an efficient medium for the selective enrichment of lipase inhibitors from natural products. A simple and rapid approach was proposed to fabricate lipase-adsorbed nanotubes through electrostatic interaction. Results showed that more than 85% lipase was adsorbed into nanotubes in 90 min, and approximately 80% of the catalytic activity was maintained compared with free lipase. The specificity and reproducibility of the proposed approach were validated by screening a known lipase inhibitor (i.e., orlistat) from a mixture that contains active and inactive compounds. Moreover, we applied this approach with high performance liquid chromatography-mass spectrometry technique to screen lipase inhibitors from the Magnoliae cortex extract, a medicinal plant used for treating obesity. Two novel biphenyl-type natural lipase inhibitors magnotriol A and Magnaldehyde B were identified, and their IC50 values were determined as 213.03 and 96.96 muM, respectively. The ligand-enzyme interactions of Magnaldehyde B were further investigated by molecular docking. Our findings proved that enzyme-adsorbed nanotube could be used as a feasible and selective affinity medium for the rapid screening of enzyme inhibitors from complex mixtures.

Apoptosis-inducing and antitumor activity of neolignans isolated from Magnolia officinalis in HeLa cancer cells.[Pubmed:23192855]

Phytother Res. 2013 Sep;27(9):1419-22.

Two neolignans, 4'-methoxymagndialdehyde (1) and Magnaldehyde B (2), were isolated from the stem bark of Magnolia officinalis (Magnoliaceae), evaluated for apoptosis-inducing effects in human cervical epitheloid carcinoma HeLa cells. The apoptosis-inducing activity of compounds 1 and 2 were assessed by DNA content using flow cytometric analysis. In the immunoblotting analysis, the treatment with 1 and 2 resulted in the cleavage of procaspase-8 and -3 and poly(ADP-ribose)polymerase into active forms. In addition, in vivo, the administration of 2 to Lewis lung carcinoma-inoculated mice evidenced a significant inhibition of tumor growth (volume) with reduction of 28.7% at concentration of 20 mg/kg, as compared with the control mice. These findings suggest that 2 can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent.

Keywords:

Magnaldehyde B,92829-72-6,Natural Products, buy Magnaldehyde B , Magnaldehyde B supplier , purchase Magnaldehyde B , Magnaldehyde B cost , Magnaldehyde B manufacturer , order Magnaldehyde B , high purity Magnaldehyde B

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: