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Ophiopogonanone B

CAS# 1316759-83-7

Ophiopogonanone B

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Quality Control of Ophiopogonanone B

Number of papers citing our products

Chemical structure

Ophiopogonanone B

3D structure

Chemical Properties of Ophiopogonanone B

Cas No. 1316759-83-7 SDF Download SDF
PubChem ID 53468064 Appearance Powder
Formula C18H18O5 M.Wt 314.33
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3R)-5,7-dihydroxy-3-[(4-methoxyphenyl)methyl]-6-methyl-2,3-dihydrochromen-4-one
SMILES CC1=C(C=C2C(=C1O)C(=O)C(CO2)CC3=CC=C(C=C3)OC)O
Standard InChIKey OOHKTNVQRTUZRS-GFCCVEGCSA-N
Standard InChI InChI=1S/C18H18O5/c1-10-14(19)8-15-16(17(10)20)18(21)12(9-23-15)7-11-3-5-13(22-2)6-4-11/h3-6,8,12,19-20H,7,9H2,1-2H3/t12-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ophiopogonanone B

The roots of Ophiopogon japonicus

Protocol of Ophiopogonanone B

Structure Identification
Carbohydr Res. 2011 Feb 1;346(2):253-8.

Novel steroidal saponins from Liriope graminifolia (Linn.) Baker with anti-tumor activities.[Pubmed: 21163470 ]

Phytochemical investigation of the underground parts of Liriope graminifolia (Linn.) Baker resulted in the isolation of two new steroidal saponins lirigramosides A (1) and B (2) along with four known compounds.
METHODS AND RESULTS:
The structures were determined by extensive spectral analysis, including two-dimensional (2D) NMR spectroscopy and chemical methods, to be 3-O-[β-d-xylopyranosyl-(1→3)-α-l-arabinopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranosyl-(25S)-spirost-5-ene-3β,17α-diol (1), 1-O-[α-l-rhamnopyranosyl-(1→2)-β-d-xylopyranosyl]-(25R)-ruscogenin (2), 1-O-β-d-xylopyranosyl-3-O-α-l-rhamnopyranosyl-(25S)-ruscogenin (3), 3-O-α-l-rhamnopyranosyl-1-O-sulfo-(25S)-ruscogenin (4), methylOphiopogonanone B (5), and 5,7-dihydroxy-3-(4-methoxybenzyl)-6-methyl-chroman-4-one, (Ophiopogonanone B, 6), respectively. Compound 1 has a new (25S)-spirost-5-ene-3β,17α-diol ((25S)-pennogenin) aglycone moiety.
CONCLUSIONS:
The isolated compounds were evaluated for their cytotoxic activities against Hela and SMMC-7721 cells.

Ophiopogonanone B Dilution Calculator

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Preparing Stock Solutions of Ophiopogonanone B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1814 mL 15.9068 mL 31.8137 mL 63.6274 mL 79.5342 mL
5 mM 0.6363 mL 3.1814 mL 6.3627 mL 12.7255 mL 15.9068 mL
10 mM 0.3181 mL 1.5907 mL 3.1814 mL 6.3627 mL 7.9534 mL
50 mM 0.0636 mL 0.3181 mL 0.6363 mL 1.2725 mL 1.5907 mL
100 mM 0.0318 mL 0.1591 mL 0.3181 mL 0.6363 mL 0.7953 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ophiopogonanone B

Novel steroidal saponins from Liriope graminifolia (Linn.) Baker with anti-tumor activities.[Pubmed:21163470]

Carbohydr Res. 2011 Feb 1;346(2):253-8.

Phytochemical investigation of the underground parts of Liriope graminifolia (Linn.) Baker resulted in the isolation of two new steroidal saponins lirigramosides A (1) and B (2) along with four known compounds. The structures were determined by extensive spectral analysis, including two-dimensional (2D) NMR spectroscopy and chemical methods, to be 3-O-[beta-d-xylopyranosyl-(1-->3)-alpha-l-arabinopyranosyl-(1-->2)-[alpha-l-rhamn opyranosyl-(1-->4)]-beta-d-glucopyranosyl-(25S)-spirost-5-ene-3beta,17alpha-diol (1), 1-O-[alpha-l-rhamnopyranosyl-(1-->2)-beta-d-xylopyranosyl]-(25R)-ruscogenin (2), 1-O-beta-d-xylopyranosyl-3-O-alpha-l-rhamnopyranosyl-(25S)-ruscogenin (3), 3-O-alpha-l-rhamnopyranosyl-1-O-sulfo-(25S)-ruscogenin (4), methylOphiopogonanone B (5), and 5,7-dihydroxy-3-(4-methoxybenzyl)-6-methyl-chroman-4-one, (Ophiopogonanone B, 6), respectively. Compound 1 has a new (25S)-spirost-5-ene-3beta,17alpha-diol ((25S)-pennogenin) aglycone moiety. The isolated compounds were evaluated for their cytotoxic activities against Hela and SMMC-7721 cells.

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