Tangshenoside ICAS# 117278-74-7 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 117278-74-7 | SDF | Download SDF |
| PubChem ID | 6441191 | Appearance | Powder |
| Formula | C29H42O18 | M.Wt | 678.6 |
| Type of Compound | Phenylpropanoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-[(E)-3-[3,5-dimethoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-enoxy]-3-methyl-5-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoic acid | ||
| SMILES | CC(CC(=O)O)(CC(=O)OCC=CC1=CC(=C(C(=C1)OC)OC2C(C(C(C(O2)CO)O)O)O)OC)OC3C(C(C(C(O3)CO)O)O)O | ||
| Standard InChIKey | ABKPQICIFGNRAA-YCRPTBBLSA-N | ||
| Standard InChI | InChI=1S/C29H42O18/c1-29(9-18(32)33,47-28-25(40)23(38)21(36)17(12-31)45-28)10-19(34)43-6-4-5-13-7-14(41-2)26(15(8-13)42-3)46-27-24(39)22(37)20(35)16(11-30)44-27/h4-5,7-8,16-17,20-25,27-28,30-31,35-40H,6,9-12H2,1-3H3,(H,32,33)/b5-4+/t16-,17-,20-,21-,22+,23+,24-,25-,27+,28+,29?/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as the index compound. It has α-glucosidase inhibition activity. |
| Targets | α-glucosidase |
| Structure Identification | J Ethnopharmacol. 2019 May 23;236:31-41.Exploring on the bioactive markers of Codonopsis Radix by correlation analysis between chemical constituents and pharmacological effects.[Pubmed: 30776470]Codonopsis Radix is a commonly used traditional Chinese medicine, and has the effect of strengthening spleen and tonifying lung, nourishing blood and engendering liquid. In addition, it is also used as important food materials.
The aim of the study was to explain the underlying correlations between chemical constituents and pharmacological effects and explore the bioactive markers of Codonopsis Radix.
Agricultural Chemistry & Biotechnology, 2006, 49(4):162-164.α-Glucosidase Inhibitors from the Roots of Codonopsis lanceolata Trautv.[Reference: WebLink]Codonopsis lanceolata Trautv. is a plant of the Campanulaceae family, which is distributed throughout Korea, Japan and China. C. lanceolata has been cultivated and its roots have been used as food especially in Korea. Other Codonopsis species, C. pilosula and C. tangshen were used as medicine (Tang-Sam) for ulcers, memory improvement and immunostimulating; however, C. lanceolata was treated as an adulterant in Japan and China.1,2). |
Tangshenoside I Dilution Calculator
Tangshenoside I Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4736 mL | 7.3681 mL | 14.7362 mL | 29.4724 mL | 36.8406 mL |
| 5 mM | 0.2947 mL | 1.4736 mL | 2.9472 mL | 5.8945 mL | 7.3681 mL |
| 10 mM | 0.1474 mL | 0.7368 mL | 1.4736 mL | 2.9472 mL | 3.6841 mL |
| 50 mM | 0.0295 mL | 0.1474 mL | 0.2947 mL | 0.5894 mL | 0.7368 mL |
| 100 mM | 0.0147 mL | 0.0737 mL | 0.1474 mL | 0.2947 mL | 0.3684 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Exploring on the bioactive markers of Codonopsis Radix by correlation analysis between chemical constituents and pharmacological effects.[Pubmed:30776470]
J Ethnopharmacol. 2019 May 23;236:31-41.
ETHNOPHARMACOLOGICAL RELEVANCE: Codonopsis Radix is a commonly used traditional Chinese medicine, and has the effect of strengthening spleen and tonifying lung, nourishing blood and engendering liquid. In addition, it is also used as important food materials. AIM OF THE STUDY: The aim of the study was to explain the underlying correlations between chemical constituents and pharmacological effects and explore the bioactive markers of Codonopsis Radix. MATERIALS AND METHODS: Codonopsis Radix samples from Min county, Gansu province processed with different methods were taken as the materials, UPLC-ESI-Q-TOF-MS/MS analysis was conducted to identify the compounds and establish UPLC fingerprint. Meanwhile, hematopoietic and immunologic functions of Codonopsis Radix were investigated to obtain relevant pharmacological index. Then, the correlation analysis between chemical constituents in UPLC fingerprints and pharmacological effects was carried out. The plant name was confirmed to the database "The Plant List" (www.theplantlist.org). RESULTS: According to the results of canonical correlation analysis, tryptophan, syringin, Tangshenoside I, codonopyrrolidium A, lobetyolin and two unknown compounds might be the potential bioactive markers related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as the index compounds. CONCLUSION: This study illustrated the underlying correlations between chemical constituents and pharmacological effects, explored the pharmacological material basis, and could lay a foundation for the improvement of quality standard of Codonopsis Radix.
[Study on HPLC specific chromatograms of Lu Dangshen].[Pubmed:26666039]
Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(14):2854-61.
In this paper, the RP-HPLC specific chromatography was adopted, with DIKMA-C18 (4.6 mm x 250 mm, 5 microm) as the chromatographic column, with a gradient elution compose of acetonitrile and 0.1% phosphoric acid at flow rate of 0.8 mL . min(-1), the detection wavelength was 220 nm. The difference of the HPLC specific chromatograms between the Lu Dangshen and other different base sources and different producing area of Codonopsis Radix was compared, involved in the similarities and differences of the number and the relative peak area of characteristic peaks in the HPLC specific chromatograms. The HPLC specific chromatograms of Lu Dangshen was established and the relative retention times of seven peaks was determined, and the peaks of codonopyrrolidium B, syringin, lobetyolin, Tangshenoside I and atractylenoide III were identified; The HPLC specific chromatograms of Lu Dangshen provided a method for scientific evaluation and effective control the quality of Lu Dangshen from Shanxi famous-region.
Chemical fingerprinting of Codonopsis pilosula and simultaneous analysis of its major components by HPLC-UV.[Pubmed:24497036]
Arch Pharm Res. 2014;37(9):1148-58.
Although Codonopsis pilosula (C. pilosula) has long been considered as an important herbal medicine, no analytical method of marker compounds for quality assessment is registered in the Korean Pharmacopoeia. We developed a simple and robust analytical method of three marker components lobetyolin (1), lobetyol (2), and Tangshenoside I (3) using HPLC-UV method. We also confirmed the three marker components using UPLC-qTOF/MS method. Various extraction conditions were optimized to achieve three marker compounds with faster extraction kinetics and higher recovery. The analytical condition was then validated by determining the linearity, accuracy, precision, limit of detection, limit of quantification, recovery, repeatability, robustness, and stability. By this method, the three markers were successfully quantified in 38 commercial samples along with three related species that are sometimes used as alternatives to C. pilosula. Finally, principal component and hierarchical clustering analyses were conducted to show the practicality of the method developed for the quality evaluation of C. pilosula.
HPLC/UV analysis of polyacetylenes, phenylpropanoid and pyrrolidine alkaloids in medicinally used Codonopsis species.[Pubmed:24453136]
Phytochem Anal. 2014 May-Jun;25(3):213-9.
INTRODUCTION: Codonopsis Radix is commonly used as a tonic in traditional Chinese medicine. However, there is no suitable method to assess the quality of Codonopsis Radix based on multiple components having potential bioactivities. OBJECTIVE: To establish a HPLC/UV method for simultaneous quantitation of polyacetylenes (lobetyol, lobetyolin, lobetyolinin, cordifolioidyne B), phenylpropanoid (Tangshenoside I) and pyrrolidine alkaloids (codonopyrrolidiums A, B) in Codonopsis Radix. METHODS: Large-scale methanol extraction of Codonopsis Radix, followed by chromatographic separation, provided the seven analytes for quantitation standards. Ultrasound-assisted methanol extracts of samples were analysed using reversed phase, gradient elution HPLC monitored at 215 nm. RESULTS: The method developed allowed efficient separation of the seven compounds and the detection and quantitation limits of the seven analytes were 0.10-0.32 microg/mL and 0.35-1.07 microg/mL, respectively. All calibration curves showed good linearities (r>0.9993) within the test ranges. Intraday and interday precisions were good with RSD<2.84%. The recoveries of all analytes ranged from 95.8 to 104.7%. CONCLUSION: HPLC/UV is an efficient and accurate method of analysis for simultaneous quantitation of seven components in Codonopsis Radix.
Quality evaluation of medicinally-used Codonopsis species and Codonopsis Radix based on the contents of pyrrolidine alkaloids, phenylpropanoid and polyacetylenes.[Pubmed:24203345]
J Nat Med. 2014 Apr;68(2):326-39.
A comparative study of 56 specimens of three medicinally-used Codonopsis taxa collected from China and 54 commercial samples of Codonopsis Radix available in Chinese, Japanese and Korean markets was carried out by quantitative analysis of seven major components: codonopyrrolidium B (1), codonopyrrolidium A (2), Tangshenoside I (3), cordifolioidyne B (4), lobetyolinin (5), lobetyolin (6) and lobetyol (7). The quantitative results, based on a well-established HPLC-DAD method, indicated that the contents of these seven compounds varied considerably among the samples, not only inter-species but also intra-species. C. pilosula and C. pilosula var. modesta showed similar chemical compositions, while C. tangshen differed considerably from these two in chemical composition. The results of principal component analysis (PCA) indicated that two main groups were classified; one group mainly included C. pilosula, C. pilosula var. modesta and the commercial samples derived from these two taxa, while the other group was composed of C. tangshen and its derived commercial samples. Compound 1 was the main component in the roots of C. pilosula and C. pilosula var. modesta, while 3 and 2 had relatively high contents in the roots of C. tangshen. Therefore, 3, 2 and 1 could be chemical markers to differentiate C. tangshen from C. pilosula and C. pilosula var. modesta.
[Determination of tangshenoside I in Codonopsis pilosula Nannf. by TLC-UV spectrophotometric method].[Pubmed:2092716]
Zhongguo Zhong Yao Za Zhi. 1990 Sep;15(9):553-5, 577.
A method of thin layer chromatographic separation and ultraviolet spectrophotometric determination of Tangshenoside I in Codonopsis pilosula is described. A comparison of the contents in various samples is made. The contents of Tangshenoside I in frosted sample have been found to be twice as much as in normal drug. The recovery of Tangshenoside I is 99.92% and the coefficient of variation of eight samplings is 1.77%.
