Pilosidine

CAS# 229971-57-7

Pilosidine

2D Structure

Catalog No. BCN8707----Order now to get a substantial discount!

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3D structure

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Pilosidine

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Chemical Properties of Pilosidine

Cas No. 229971-57-7 SDF Download SDF
PubChem ID 100964856 Appearance Powder
Formula C23H26O11 M.Wt 478.5
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-[(2~{R},3~{R},4~{a}~{R},6~{R},7~{S},8~{S})-2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-6-(hydroxymethyl)-3,4~{a},6,7,8,8~{a}-hexahydro-2~{H}-pyrano[2,3-b][1,4]dioxin-3-yl]-1-(3,4-dihydroxyphenyl)propan-1-one
SMILES C1=CC(=C(C=C1C2C(OC3C(O2)C(C(C(O3)CO)O)O)CCC(=O)C4=CC(=C(C=C4)O)O)O)O
Standard InChIKey XBAOUURGPFGYBL-VHONBLLRSA-N
Standard InChI InChI=1S/C23H26O11/c24-9-18-19(30)20(31)22-23(33-18)32-17(21(34-22)11-2-4-14(27)16(29)8-11)6-5-12(25)10-1-3-13(26)15(28)7-10/h1-4,7-8,17-24,26-31H,5-6,9H2/t17-,18-,19-,20+,21-,22?,23-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pilosidine

The herbs of Curculigo capitulata

Biological Activity of Pilosidine

DescriptionPilosidine has vasoconstrictor activity, it showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.
In vitro

Benzylbenzoate and norlignan glucosides from Curculigo pilosa: structural analysis and in vitro vascular activity[Pubmed: 11140602 ]

Phytochemistry, 2000, 55(5):411-417.


METHODS AND RESULTS:
From the rhizomes of Curculigo pilosa, two benzylbenzoate diglucosides, piloside A and piloside B, and a glucosyl-fused norlignan, Pilosidine, previously obtained only as the tetra-O-methyl derivative, were isolated.
CONCLUSIONS:
Pilosidine showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.

Protocol of Pilosidine

Animal Research

Studies on vasoconstrictor activity of Curculigo pilosa extracts and of its isolated compounds.[Pubmed: 11482757]

Farmaco. 2001 May-Jul;56(5-7):353-6.


METHODS AND RESULTS:
The Curculigo pilosa total extract, its butanolic fraction (0.5 microg-100 mg/kg) and the most active in vitro compound structurally similar to adrenaline, Pilosidine (10 ng-l mg/kg), caused a reversible and dose-dependent increase in blood pressure in anaesthetized rat. This hypertensive effect is partially reversed (90%) by the prior administration of phentolamine (1 mg/kg) and abolished by pre-treatment with phentolamine (1 mg/kg) and atenolol (100 microg/kg). Neither tachiphylaxis nor any toxic effects were observed.
CONCLUSIONS:
These experimental findings suggest an interaction between C. pilosa and the peripheral adrenergic system (particularly with alpha1 and beta1 receptors); the structure of the bioactive glucosides could be important in evoking this effect.

Pilosidine Dilution Calculator

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Pilosidine Molarity Calculator

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Preparing Stock Solutions of Pilosidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0899 mL 10.4493 mL 20.8986 mL 41.7973 mL 52.2466 mL
5 mM 0.418 mL 2.0899 mL 4.1797 mL 8.3595 mL 10.4493 mL
10 mM 0.209 mL 1.0449 mL 2.0899 mL 4.1797 mL 5.2247 mL
50 mM 0.0418 mL 0.209 mL 0.418 mL 0.8359 mL 1.0449 mL
100 mM 0.0209 mL 0.1045 mL 0.209 mL 0.418 mL 0.5225 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pilosidine

Benzylbenzoate and norlignan glucosides from Curculigo pilosa: structural analysis and in vitro vascular activity.[Pubmed:11140602]

Phytochemistry. 2000 Nov;55(5):411-7.

From the rhizomes of Curculigo pilosa, two benzylbenzoate diglucosides, piloside A and piloside B, and a glucosyl-fused norlignan, Pilosidine, previously obtained only as the tetra-O-methyl derivative, were isolated. Pilosidine showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.

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