Pilosidine

CAS# 229971-57-7

Pilosidine

Catalog No. BCN8707----Order now to get a substantial discount!

Product Name & Size Price Stock
Pilosidine: 5mg $483 In Stock
Pilosidine: 10mg Please Inquire In Stock
Pilosidine: 20mg Please Inquire Please Inquire
Pilosidine: 50mg Please Inquire Please Inquire
Pilosidine: 100mg Please Inquire Please Inquire
Pilosidine: 200mg Please Inquire Please Inquire
Pilosidine: 500mg Please Inquire Please Inquire
Pilosidine: 1000mg Please Inquire Please Inquire

Quality Control of Pilosidine

Number of papers citing our products

Chemical structure

Pilosidine

3D structure

Chemical Properties of Pilosidine

Cas No. 229971-57-7 SDF Download SDF
PubChem ID 100964856 Appearance Powder
Formula C23H26O11 M.Wt 478.5
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-[(2~{R},3~{R},4~{a}~{R},6~{R},7~{S},8~{S})-2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-6-(hydroxymethyl)-3,4~{a},6,7,8,8~{a}-hexahydro-2~{H}-pyrano[2,3-b][1,4]dioxin-3-yl]-1-(3,4-dihydroxyphenyl)propan-1-one
SMILES C1=CC(=C(C=C1C2C(OC3C(O2)C(C(C(O3)CO)O)O)CCC(=O)C4=CC(=C(C=C4)O)O)O)O
Standard InChIKey XBAOUURGPFGYBL-VHONBLLRSA-N
Standard InChI InChI=1S/C23H26O11/c24-9-18-19(30)20(31)22-23(33-18)32-17(21(34-22)11-2-4-14(27)16(29)8-11)6-5-12(25)10-1-3-13(26)15(28)7-10/h1-4,7-8,17-24,26-31H,5-6,9H2/t17-,18-,19-,20+,21-,22?,23-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pilosidine

The herbs of Curculigo capitulata

Biological Activity of Pilosidine

DescriptionPilosidine has vasoconstrictor activity, it showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.
In vitro

Benzylbenzoate and norlignan glucosides from Curculigo pilosa: structural analysis and in vitro vascular activity[Pubmed: 11140602 ]

Phytochemistry, 2000, 55(5):411-417.


METHODS AND RESULTS:
From the rhizomes of Curculigo pilosa, two benzylbenzoate diglucosides, piloside A and piloside B, and a glucosyl-fused norlignan, Pilosidine, previously obtained only as the tetra-O-methyl derivative, were isolated.
CONCLUSIONS:
Pilosidine showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.

Protocol of Pilosidine

Animal Research

Studies on vasoconstrictor activity of Curculigo pilosa extracts and of its isolated compounds.[Pubmed: 11482757]

Farmaco. 2001 May-Jul;56(5-7):353-6.


METHODS AND RESULTS:
The Curculigo pilosa total extract, its butanolic fraction (0.5 microg-100 mg/kg) and the most active in vitro compound structurally similar to adrenaline, Pilosidine (10 ng-l mg/kg), caused a reversible and dose-dependent increase in blood pressure in anaesthetized rat. This hypertensive effect is partially reversed (90%) by the prior administration of phentolamine (1 mg/kg) and abolished by pre-treatment with phentolamine (1 mg/kg) and atenolol (100 microg/kg). Neither tachiphylaxis nor any toxic effects were observed.
CONCLUSIONS:
These experimental findings suggest an interaction between C. pilosa and the peripheral adrenergic system (particularly with alpha1 and beta1 receptors); the structure of the bioactive glucosides could be important in evoking this effect.

Pilosidine Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Pilosidine Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Pilosidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0899 mL 10.4493 mL 20.8986 mL 41.7973 mL 52.2466 mL
5 mM 0.418 mL 2.0899 mL 4.1797 mL 8.3595 mL 10.4493 mL
10 mM 0.209 mL 1.0449 mL 2.0899 mL 4.1797 mL 5.2247 mL
50 mM 0.0418 mL 0.209 mL 0.418 mL 0.8359 mL 1.0449 mL
100 mM 0.0209 mL 0.1045 mL 0.209 mL 0.418 mL 0.5225 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Pilosidine

Benzylbenzoate and norlignan glucosides from Curculigo pilosa: structural analysis and in vitro vascular activity.[Pubmed:11140602]

Phytochemistry. 2000 Nov;55(5):411-7.

From the rhizomes of Curculigo pilosa, two benzylbenzoate diglucosides, piloside A and piloside B, and a glucosyl-fused norlignan, Pilosidine, previously obtained only as the tetra-O-methyl derivative, were isolated. Pilosidine showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.

Keywords:

Pilosidine,229971-57-7,Natural Products, buy Pilosidine , Pilosidine supplier , purchase Pilosidine , Pilosidine cost , Pilosidine manufacturer , order Pilosidine , high purity Pilosidine

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: