Hot Natural Products & Bioactive Compounds

1. 13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug.
2. 13-Methylberberine may reduce circulating HMGB1 levels and increase survival in a mouse model of sepsis by activating AMP-activated protein kinase (AMPK).
3. 13-Methylberberine can be useful as an immunotherapeutic compound for induction of IL-12, which is potentially applicable for tumors, infectious disease, and airway inflammation.

1. Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.
2. Lappaol C has potential chemosensitizing activity, it may be candidates for developing novel adjuvant anticancer agents.

1. Magnaldehyde B is a natural lipase inhibitor(IC50= 96.96 uM).
2. Magnaldehyde B can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent.

1. Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL.
2. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity against human hepatocellular carcinoma cell (BEL-7402), human lung epithelial (A-549) and human ileocecal adenocarcinoma cell (HCT-8).

1. Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.

1. Cafestol has anticarcinogenic activity.
2. Cafestol acts as an agonist ligand for both FXR and PXR, and this may contribute to its impact on cholesterol homeostasis.
3. Cafestol has an anti-inflammatory property, it inhibits Cyclic-Strain-induced interleukin-8, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 production in vascular endothelial cells.
4. Cafestol has protective effects against the CCl(4)-induced hepatotoxicity, which possibly involve mechanisms related to its ability to block the CYP2E1-mediated CCl(4) bioactivation and free radical scavenging effects.
5. Cafestol is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages.
6. Cafestol has a peripheral antinociceptive effect and suggest that this effect is mediated by the release of endogenous opioids.
7. Cafestol inhibits angiogenesis by affecting the angiogenic signaling pathway.
8. Cafestol has antidiabetic activity, it increases glucose-stimulated insulin secretion in vitro and increases glucose uptake in human skeletal muscle cells.
9. Cafestol has a weak inhibitory effect on osteoclastogenesis and promotes osteoblast differentiation.

1. Protohypericin exhibits photocytotoxicity.

1. Glabrol is a PTP1B inhibitor.
2. Glabrol is a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15 uM.
3. Glabrol has hypnotic effects, it induces sleep via a positive allosteric modulation of GABA(A)-BZD receptors.
4. Glabrol possesses significant antimicrobial activity in vitro.
5. Glabrol shows a noncompetitive type of inhibition against diacylglycerol acyltransferase (DGAT) with an IC50 value of 8.0 microM, it may have potential therapy for the treatment in obesity and type 2 diabetes patients.