Hot Natural Products & Bioactive Compounds

1. 6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals.
2. 6,8-Diprenylorobol shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor (ER) antagonist.
3. 6,8-Diprenylorobol shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM).
4. 6,8-Diprenylorobol has antioxidant activity, it can reduce A2E photooxidation in a dose dependent manner.
5. 6,8-Diprenylorobol is evaluated against the AIDS-related opportunistic fungal pathogens, Candida albicans and Cryptococcus neoformans.
6. 6,8-Diprenylorobol can protect against 6-OHDA-induced neurotoxicity by enhancing the ubiquitin/proteasome-dependent degradation of α-synuclein and synphilin-1, suggesting that it may be a possible candidate for the treatment of neurodegenerative diseases.

N-p-Coumaroyloctopamine is a natural product from potato tuber tissue.

1. Precocene II is a botanically derived chemical that inhibits the production of juvenile hormone (JH) in insects.
2. Precocene II is highly toxic to adult female Rhodnius and treatment of newly emerged females prevented oogenesis.
3. Precocene II , an insect growth regulator that is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats.

1. Alstonine is an indole alkaloid that has an antipsychotic activity, by decreasing glutamate uptake and using the step-down inhibitory avoidance paradigm and MK801-induced working memory deficits in mice.
2. Alstonine prevents the expected fasting-induced decrease in glucose levels.

1. Akuammidine shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 microM at mu-, delta- and kappa-opioid binding sites, respectively; the agonist actions of akuammidine in the mouse-isolated vas deferens were antagonised by naloxone and the mu-opioid receptor selective antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) confirming an action at mu-opioid receptors.
2. Akuammigine competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68.
3. Akuammigine has in vitro antimalarial activity.

Standard reference

1. Cannabispirol has a weak antibacterial effect which is more definite on plasmid carrying bacteria than plasmidless ones, and inhibits intercellular plasmid transfer and transforming activity of plasmid DNA.

1. Cyclomorusin , neoCyclomorusin and kuwanon C inhibited cholinesterase enzyme in a dose-dependent manner with K(i) values ranging between 3.1 and 37.5 uM and between 1.7 and 19.1 uM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively.
2. Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM.
3. Cyclomorusin evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophils.