Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC4513 | Mubritinib (TAK 165) |
| Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo. | |
| BCC4527 | Cimetidine |
| Widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand. | |
| BCC4528 | Clemastine Fumarate |
| H1-receptor antagonist. Enhances differentiation of oligodendrocyte progenitor cells into myelin basic protein-positive oligodendrocytes in vitro and promotes remyelination in vivo. Also displays antimuscarinic properties. Clinically-used antihistamine. | |
| BCC4530 | Histamine 2HCl |
| Endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo. | |
| BCC4531 | Ketotifen Fumarate |
| An H1 receptor antagonist. | |
| BCC4533 | Ranitidine Hydrochloride |
| Potent, selective and competitive histamine H2 receptor antagonist (pA2 = 6.95 - 7.2). Inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food in vivo. Also inhibits aspirin-induced gastric lesions. | |
| BCC4540 | Desloratadine |
| High affinity histamine H1 receptor antagonist (Ki = 0.87 nM); active metabolite of loratadine. Anti-inflammatory. | |
| BCC4542 | Fexofenadine HCl |
| Selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects. | |
