Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC4565 | Biperiden HCl |
| Muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity. | |
| BCC4569 | Donepezil HCl |
| Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active. | |
| BCC4574 | Tropicamide |
| M4 selective muscarinic receptor antagonist. | |
| BCC4578 | Pancuronium dibromide |
| Nicotine (neuromuscular) antagonist. Skeletal muscle relaxant. | |
| BCC4586 | Tolterodine tartrate |
| High affinity muscarinic receptor antagonist (Ki = 3.3 nM). Active at all muscarinic receptor subtypes (M1 - M5); exhibits a greater effect on the bladder than salivary glands in vivo. | |
| BCC4590 | NMDA (N-Methyl-D-aspartic acid) |
| Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor. | |
| BCC4593 | (-)-MK 801 |
| Less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate. | |
| BCC4595 | VU 0357121 |
| Positive allosteric modulator of mGlu5 receptors (EC50 = 33 nM). Binds to a site distinct from that bound by MPEP. | |
