Clauszoline M

CAS# 187110-72-1

Clauszoline M

Catalog No. BCN4683----Order now to get a substantial discount!

Product Name & Size Price Stock
Clauszoline M: 5mg $903 In Stock
Clauszoline M: 10mg Please Inquire In Stock
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Quality Control of Clauszoline M

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Chemical structure

Clauszoline M

3D structure

Chemical Properties of Clauszoline M

Cas No. 187110-72-1 SDF Download SDF
PubChem ID 10823162 Appearance Yellow powder
Formula C13H9NO3 M.Wt 227.22
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2,8-dihydroxy-9H-carbazole-3-carbaldehyde
SMILES C1=CC2=C(C(=C1)O)NC3=CC(=C(C=C23)C=O)O
Standard InChIKey IGPNSSMZXGKMGU-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H9NO3/c15-6-7-4-9-8-2-1-3-11(16)13(8)14-10(9)5-12(7)17/h1-6,14,16-17H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Clauszoline M

The herbs of Clausena dunniana

Biological Activity of Clauszoline M

Description1. Clauszoline M shows a significant anti-tuberculosis activity.
TargetsAntifection

Clauszoline M Dilution Calculator

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Clauszoline M Molarity Calculator

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Preparing Stock Solutions of Clauszoline M

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.401 mL 22.0051 mL 44.0102 mL 88.0204 mL 110.0255 mL
5 mM 0.8802 mL 4.401 mL 8.802 mL 17.6041 mL 22.0051 mL
10 mM 0.4401 mL 2.2005 mL 4.401 mL 8.802 mL 11.0026 mL
50 mM 0.088 mL 0.4401 mL 0.8802 mL 1.7604 mL 2.2005 mL
100 mM 0.044 mL 0.2201 mL 0.4401 mL 0.8802 mL 1.1003 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Clauszoline M

Chemical constituents of Clausena excavata: isolation and structure elucidation of novel furanone-coumarins with inhibitory effects for tumor-promotion.[Pubmed:11000023]

J Nat Prod. 2000 Sep;63(9):1218-24.

A study of the chemical constituents of the leaves of Clausena excavata cultivated in a greenhouse led to the isolation and identification of 10 new furanone-coumarins named clauslactones A (1), B (2), C (3), D (4), E (5), F (6), G (7), H (8), I (9), and J (10), together with a known carbazole, Clauszoline M, and a coumarin, umbelliferone. The new coumarins contain a C(10) terpenoid side chain with a furanone (gamma-lactone) moiety. Further, in clauslactones A-D (1-4), the terpenoid side chain was shown to be linked to the 7,8-dioxygenated coumarin skeleton through a 1, 4-dioxane ring system. This is the first example of coumarins with these structural characteristics in nature. These furanone-coumarins were found to exhibit inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus early antigen activation in Raji cells.

Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCdelta phosphorylation.[Pubmed:22093759]

Eur J Med Chem. 2012 Jan;47(1):214-20.

Sixteen carbazole alkaloids from Clausena vestita D. D. Tao were extracted, and their anti-tumor activities were evaluated. Among the extracts, Clauszoline-I exhibited an obvious growth inhibitory activity against several cancer cell lines through its ability to induce cell cycle arrest in the S and G2/M phases. A dramatic morphologic change with decreased F-actin staining and RhoA activity was found in Clauszoline-I treated HepG2 cells, in which the phosphorylation of PKCdelta (Ser643) was inhibited. Our results indicated that induction cell cycle arrest by Clauszoline-I might be achieved by decreasing the RhoA activity via the inhibition of PKCdelta phosphorylation.

First total synthesis of the 7-oxygenated carbazole alkaloids clauszoline-K, 3-formyl-7-hydroxycarbazole, clausine M, clausine N and the anti-HIV active siamenol using a highly efficient palladium-catalyzed approach.[Pubmed:17036106]

Org Biomol Chem. 2006 Sep 7;4(17):3215-9.

Using a convergent palladium-catalyzed construction of the carbazole framework as the key step we have achieved a short synthesis of the 7-oxygenated carbazole alkaloids clauszoline-K, 3-formyl-7-hydroxycarbazole, clausine C (clauszoline-L), clausine M, clausine N and the anti-HIV active siamenol.

Anti-tuberculosis activity and structure-activity relationships of oxygenated tricyclic carbazole alkaloids and synthetic derivatives.[Pubmed:28094223]

Bioorg Med Chem. 2017 Nov 15;25(22):6167-6174.

A series of 49 oxygenated tricyclic carbazole derivatives has been tested for inhibition of the growth of Mycobacterium tuberculosis and a mammalian cell line (vero cells). From this series, twelve carbazoles showed a significant anti-TB activity. The four most active compounds were the naturally occurring carbazole alkaloids clauszoline-M (45), murrayaline-C (41), carbalexin-C (27), and the synthetic carbazole derivative 22 with MIC90 values ranging from 1.5 to 3.7muM. The active compounds were virtually nontoxic for the mammalian cell line in the concentration range up to 50muM.

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