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(20R)-Ginsenoside Rh1

CAS# 80952-71-2

(20R)-Ginsenoside Rh1

Catalog No. BCN3700----Order now to get a substantial discount!

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(20R)-Ginsenoside Rh1: 5mg $29 In Stock
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Chemical structure

(20R)-Ginsenoside Rh1

3D structure

Chemical Properties of (20R)-Ginsenoside Rh1

Cas No. 80952-71-2 SDF Download SDF
PubChem ID 157710 Appearance Powder
Formula C36H62O9 M.Wt 638.9
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,3R,4S,5S,6R)-2-[[(6R,8R,10R,12S,14S)-3,12-dihydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C)O)C)O)C
Standard InChIKey RAQNTCRNSXYLAH-VLBLZPEBSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of (20R)-Ginsenoside Rh1

The roots of Panax ginseng C. A. Mey.

Biological Activity of (20R)-Ginsenoside Rh1

Description(20R)-Ginsenoside Rh1 exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer.
In vitro

Pharmacological Study on Panax ginseng C.A. MEYER V. : Effects of Red Ginseng on the Experimental Disseminated Intravascular Coagulation (4). On Ginsenoside-Rg3, Rh1 and Rh2[Reference: WebLink]

Japanese Journal of Pharmacognosy, 1985, 39:123-5.


METHODS AND RESULTS:
20S, 20R ginsenoside Rg3, 20S, 20R ginsenoside Rh1, and ginsenoside Rh2 isolated from red ginseng were investigated for their effect on blood platelet aggregation and thrombin-induced conversion of fibrinogen to fibrin in vitro.
CONCLUSIONS:
20S, 20R ginsenoside Rg3 inhibited collagen- and ADP-induced blood platelet aggregation. 20S ginsenoside Rg3, 20S, 20R ginsenoside Rh1 inhibited the thrombin-induced conversion of fibrinogen to fibrin.

Protocol of (20R)-Ginsenoside Rh1

Structure Identification
Zhongguo Zhong Yao Za Zhi. 2013 Nov;38(22):3910-7.

Chemical constituents from processed rhizomes of Panax notoginseng.[Pubmed: 24558875]


METHODS AND RESULTS:
To investigate the chemical constituents of the processed rhizomes of Panax notoginseng, their 70% ethanol extract was chromatographed on macroporous resin (SP825), silica gel, RP-C18 and semi-preparative HPLC to afford compounds 1-23. On the basis of physicochemical properties and spectral data analysis, their structures were identified to be 6'-O-Acetylginsenoside Rh1 (1), ginsenoside RK3 (2), ginsenoside Rh4 (3), 20S-ginsenoside Rg3 (4), ginsenoside Rk1 (5), 20R-ginsenoside Rg3 (6), ginsenoside Rg5 (7), ginsenoside F2 (8), 20S-ginsenoside Rh1 (9), (20R)-Ginsenoside Rh1(10), gypenoside X VII (11), notoginsenoside Fa, (12), ginsenoside Ra3 (13), ginsenoside Rg1 (14), ginsenoside Re (15), notoginsenoside R2 (16), ginsenoside Rg2 (17), notoginsenoside R1 (18), ginsenoside Rd (19), ginsenoside Rb1 (20), notoginsenoside D (21), notoginsenoside R4 (22) and ginsenoside Rb2 (23), respectively. Among them, compound 1 was isolated from P. notoginseng for the first time, and compounds 4, 6, 8 and 11 were isolated from the processed P. notoginseng for the first time.
CONCLUSIONS:
According to the fingerprint profiles of raw and processed P. notoginseng, the putative chemical conversion pathways of panoxatriol and panoxadiol compounds in the processing procedure was deduced, and the results revealed the main reactions to be dehydration and glycosyl hydrolysis.

(20R)-Ginsenoside Rh1 Dilution Calculator

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Preparing Stock Solutions of (20R)-Ginsenoside Rh1

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5652 mL 7.826 mL 15.6519 mL 31.3038 mL 39.1298 mL
5 mM 0.313 mL 1.5652 mL 3.1304 mL 6.2608 mL 7.826 mL
10 mM 0.1565 mL 0.7826 mL 1.5652 mL 3.1304 mL 3.913 mL
50 mM 0.0313 mL 0.1565 mL 0.313 mL 0.6261 mL 0.7826 mL
100 mM 0.0157 mL 0.0783 mL 0.1565 mL 0.313 mL 0.3913 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (20R)-Ginsenoside Rh1

[Chemical constituents from processed rhizomes of Panax notoginseng].[Pubmed:24558875]

Zhongguo Zhong Yao Za Zhi. 2013 Nov;38(22):3910-7.

To investigate the chemical constituents of the processed rhizomes of Panax notoginseng, their 70% ethanol extract was chromatographed on macroporous resin (SP825), silica gel, RP-C18 and semi-preparative HPLC to afford compounds 1-23. On the basis of physicochemical properties and spectral data analysis, their structures were identified to be 6'-O-Acetylginsenoside Rh1 (1), ginsenoside RK3 (2), ginsenoside Rh4 (3), 20S-ginsenoside Rg3 (4), ginsenoside Rk1 (5), 20R-ginsenoside Rg3 (6), ginsenoside Rg5 (7), ginsenoside F2 (8), 20S-ginsenoside Rh1 (9), 20R-ginsenoside Rh1 (10), gypenoside X VII (11), notoginsenoside Fa, (12), ginsenoside Ra3 (13), ginsenoside Rg1 (14), ginsenoside Re (15), notoginsenoside R2 (16), ginsenoside Rg2 (17), notoginsenoside R1 (18), ginsenoside Rd (19), ginsenoside Rb1 (20), notoginsenoside D (21), notoginsenoside R4 (22) and ginsenoside Rb2 (23), respectively. Among them, compound 1 was isolated from P. notoginseng for the first time, and compounds 4, 6, 8 and 11 were isolated from the processed P. notoginseng for the first time. According to the fingerprint profiles of raw and processed P. notoginseng, the putative chemical conversion pathways of panoxatriol and panoxadiol compounds in the processing procedure was deduced, and the results revealed the main reactions to be dehydration and glycosyl hydrolysis.

Description

(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin.

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