1,3,9-Trimethyluric acidCAS# 7464-93-9 |
Quality Control & MSDS
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| Cas No. | 7464-93-9 | SDF | Download SDF |
| PubChem ID | 81972 | Appearance | Powder |
| Formula | C8H10N4O3 | M.Wt | 210.19 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1,3,9-trimethyl-7H-purine-2,6,8-trione | ||
| SMILES | CN1C2=C(C(=O)N(C(=O)N2C)C)NC1=O | ||
| Standard InChIKey | CWENCZHQIWXCCA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C8H10N4O3/c1-10-5-4(9-7(10)14)6(13)12(3)8(15)11(5)2/h1-3H3,(H,9,14) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The culture of the marine sponge Amphimedon viridis.
| Description | 1. 1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 2. 1,3,9-Trimethyluric acid shows promising anti-inflammatory effects in LPS induced murine macrophage J774 in vitro models in the concentration range of 100-1000 nM. |
| Targets | Immunology & Inflammation related |
1,3,9-Trimethyluric acid Dilution Calculator
1,3,9-Trimethyluric acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.7576 mL | 23.788 mL | 47.576 mL | 95.152 mL | 118.94 mL |
| 5 mM | 0.9515 mL | 4.7576 mL | 9.5152 mL | 19.0304 mL | 23.788 mL |
| 10 mM | 0.4758 mL | 2.3788 mL | 4.7576 mL | 9.5152 mL | 11.894 mL |
| 50 mM | 0.0952 mL | 0.4758 mL | 0.9515 mL | 1.903 mL | 2.3788 mL |
| 100 mM | 0.0476 mL | 0.2379 mL | 0.4758 mL | 0.9515 mL | 1.1894 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation and X-ray crystal structure of 1,3,9 trimethyl purine derivative having cytotoxic activities from marine sponge Amphimedon viridis (Duchassaing & Michelotti,1864)
Int.J.Sci. Res.,2017,6(1):13-17.
A new purine derivative 1,3,9-Trimethyluric acid (1) was isolated from the marine sponge Amphimedon viridis and structure were confirmed by X-ray crystallography data. Compound 1 exhibited in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 μM and also showed promising anti-inflammatory effects in LPS induced murine macrophage J774 in vitro models in the concentration range of 100-1000 nM.
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