IvachtinCaspase-3 inhibitor CAS# 745046-84-8 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 745046-84-8 | SDF | Download SDF |
| PubChem ID | 11201705 | Appearance | Powder |
| Formula | C20H21N3O7S | M.Wt | 447.46 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Limited solubility | ||
| Chemical Name | 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate | ||
| SMILES | CC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)C | ||
| Standard InChIKey | MWXJJTMEUGWKKY-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent, reversible inhibitor of caspase-3 (IC50 = 23 nM) that displays moderate selectivity over other caspases. Exhibits antiapoptotic activity in human Jurkat T cells treated with staurosporine; exhibits a higher level of protection than Z-VAD-FMK . |
Ivachtin Dilution Calculator
Ivachtin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2348 mL | 11.1742 mL | 22.3484 mL | 44.6967 mL | 55.8709 mL |
| 5 mM | 0.447 mL | 2.2348 mL | 4.4697 mL | 8.9393 mL | 11.1742 mL |
| 10 mM | 0.2235 mL | 1.1174 mL | 2.2348 mL | 4.4697 mL | 5.5871 mL |
| 50 mM | 0.0447 mL | 0.2235 mL | 0.447 mL | 0.8939 mL | 1.1174 mL |
| 100 mM | 0.0223 mL | 0.1117 mL | 0.2235 mL | 0.447 mL | 0.5587 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Ivachtin is a potent inhibitor of caspase-3 with IC50 value of 23 nM [1].
Caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. Sequential activation of caspases plays an important role in cell apoptosis.
Ivachtin is a potent and reversible inhibitor of caspase-3 in a noncompetitive way. Ivachtin was the most potent inhibitor against caspase-3, but the selectivity versus the remaining caspases was modest. In human Jurkat T cells treated with 10 μM staurosporin, Ivachtin protected cells in a higher level, which suggested that Ivachtin had a good cell permeability and antiapoptotic activity [1].
Reference:
[1]. Kravchenko DV, Kuzovkova YA, Kysil VM, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem, 2005, 48(11): 3680-3683.
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Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases.
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