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Tylosin tartrate

CAS# 74610-55-2

Tylosin tartrate

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Chemical structure

Tylosin tartrate

3D structure

Chemical Properties of Tylosin tartrate

Cas No. 74610-55-2 SDF Download SDF
PubChem ID 60196281 Appearance Powder
Formula C50H83NO23 M.Wt 1066.19
Type of Compound N/A Storage Desiccate at -20°C
Solubility H2O : ≥ 100 mg/mL (93.79 mM)
DMSO : ≥ 100 mg/mL (93.79 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (2R,3R)-2,3-dihydroxybutanedioic acid;2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
SMILES CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.C(C(C(=O)O)O)(C(=O)O)O
Standard InChIKey ICVKYYINQHWDLM-KBEWXLTPSA-N
Standard InChI InChI=1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Tylosin tartrate

DescriptionTylosin Tartrate is an antibiotic with a large macrocyclic lactone ring. Target: Antibacterial Tylosin is a bacteriostat food additive used in veterinary medicine. It has a broad spectrum of activity against gram-positive organisms and a limited range of gram-negative organisms. There is no significant evidence that tylosin resistant staphylococci of animal origin have endangered human health. Tylosin is not effective against the gram-negative intestinal flora, which thus does not lead to selection of R-factors by conjugation. From the human medical stand point, there is no reason that precludes the use of tylosin as a fee additive in animal feeds [1]. Minimum inhibitory concentrations for tylosin tartrate and other commonly used antibiotics were determined for 103 isolates. Most (82.61%) of the isolates not exposed to antibiotics in the 3 months before submission were sensitive to tylosin tartrate. These findings suggest that tylosin tartrate warrants further study as a first-line option for the treatment of dogs initially presenting with pyoderma [2].

References:
[1]. Knothe, H., A review of the medical considerations of the use of tylosin and other macrolide antibiotics as additives in animal feeds. Infection, 1977. 5(3): p. 183-7. [2]. Scott, B.A., et al., Efficacy of tylosin tartrate on canine Staphylococcus intermedius isolates in vitro. Vet Ther, 2010. 11(3): p. E1-7.

Tylosin tartrate Dilution Calculator

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Tylosin tartrate Molarity Calculator

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Preparing Stock Solutions of Tylosin tartrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.9379 mL 4.6896 mL 9.3792 mL 18.7584 mL 23.448 mL
5 mM 0.1876 mL 0.9379 mL 1.8758 mL 3.7517 mL 4.6896 mL
10 mM 0.0938 mL 0.469 mL 0.9379 mL 1.8758 mL 2.3448 mL
50 mM 0.0188 mL 0.0938 mL 0.1876 mL 0.3752 mL 0.469 mL
100 mM 0.0094 mL 0.0469 mL 0.0938 mL 0.1876 mL 0.2345 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Tylosin tartrate

Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.

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References on Tylosin tartrate

Efficacy of tylosin tartrate on canine Staphylococcus intermedius isolates in vitro.[Pubmed:20960412]

Vet Ther. 2010 Fall;11(3):E1-7.

In the past 5 years, the incidence of canine skin infections caused by resistant strains of Staphylococcus (pseud)intermedius has increased. Many older antibiotics are used to treat these infections because the sensitivity can be demonstrated in vitro. Additionally, many of these older drugs are efficacious and unlikely to induce multidrug resistance. More than a decade ago, the antibiotic Tylosin tartrate was reported to be efficacious in vitro and in vivo against Staphylococcus intermedius. The purpose of this study was to determine whether S. (pseud)intermedius isolated from untreated pyoderma cases at veterinary referral centers across the United States are sensitive in vitro to this antibiotic. Minimum inhibitory concentrations for Tylosin tartrate and other commonly used antibiotics were determined for 103 isolates. Most (82.61%) of the isolates not exposed to antibiotics in the 3 months before submission were sensitive to Tylosin tartrate. These findings suggest that Tylosin tartrate warrants further study as a first-line option for the treatment of dogs initially presenting with pyoderma.

Effect of tylosin tartrate (Tylan Soluble) on cellular immune responses in chickens.[Pubmed:9733118]

Poult Sci. 1998 Sep;77(9):1306-11.

Although many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance immune function. Tylosin is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin on cellular immune functions in chickens. There was no significant difference in adherent splenocyte chemotaxis between tylosin-treated and untreated (control) chickens. Tylosin increased splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels. Removal of adherent splenocytes before preparation of CM caused a reduction in CM proliferative activity. Tylosin also increased antitumor activity of splenocytes. These data are the first to suggest that the macrolide antibiotic, Tylosin tartrate, has a modulatory effect in chickens on the immune parameters studied.

Inhibition of microbial metabolism in anaerobic lagoons by selected sulfonamides, tetracyclines, lincomycin, and tylosin tartrate.[Pubmed:15839550]

Environ Toxicol Chem. 2005 Apr;24(4):782-8.

Antibiotics are used to maintain healthy livestock and to promote weight gain in concentrated animal feed operations. Antibiotics rarely are metabolized completely by livestock and, thus, are often present in livestock waste and in waste-treatment lagoons. The introduction of antibiotics into anaerobic lagoons commonly used for swine waste treatment has the potential for negative impacts on lagoon performance, which relies on a consortium of microbes ranging from fermentative microorganisms to methanogens. To address this concern, the effects of eight common veterinary antibiotics on anaerobic activity were studied. Anaerobic microcosms, prepared from freshly collected lagoon slurries, were amended with individual antibiotics at 10 mg/L for the initial screening study and at 1, 5, and 25 mg/L for the dose-response study. Monitored metabolic indicators included hydrogen, methane, and volatile fatty acid concentrations as well as chemical oxygen demand. The selected antibiotics significantly inhibited methane production relative to unamended controls, thus indicating that antibiotics at concentrations commonly found in swine lagoons can negatively impact anaerobic metabolism. Additionally, historical antibiotic usage seems to be a potential factor in affecting methane production. Specifically, less inhibition of methane production was noted in samples taken from the lagoon with a history of multiple-antibiotic use.

Comparative pharmacokinetics and bioavailability of tylosin tartrate and tylosin phosphate after a single oral and i.v. administration in chickens.[Pubmed:24325541]

J Vet Pharmacol Ther. 2014 Jun;37(3):312-5.

The pharmacokinetics and oral bioavailability of Tylosin tartrate and tylosin phosphate were carried out in broiler chickens according to a principle of single dose, random, parallel design. The two formulations of tylosin were given orally and intravenously at a dose level of 10 mg/kg b.w to chicken after an overnight fasting (n = 10 chickens/group). Serial blood samples were collected at different time points up to 24 h postdrug administration. A high performance liquid chromatography method was used for the determination of tylosin concentrations in chicken plasma. The tylosin plasma concentration's time plot of each chicken was analyzed by the 3P97 software. The pharmacokinetics of tylosin was best described by a one-compartmental open model 1st absorption after oral administration. After intravenous administration the pharmacokinetics of tylosin was best described by a two-compartmental open model, and there were no significant differences between Tylosin tartrate and tylosin phosphate. After oral administration, there were significant differences in the Cmax (0.18 +/- 0.01, 0.44 +/- 0.09) and AUC (0.82 +/- 0.05, 1.57 +/- 0.25)between tylosin phosphate and Tylosin tartrate. The calculated oral bioavailability (F) of Tylosin tartrate and tylosin phosphate were 25.78% and 13.73%, respectively. Above all, we can reasonably conclude that, the absorption of Tylosin tartrate is better than tylosin phosphate after oral administration.

Description

Tylosin tartrate is an antibiotic with a large macrocyclic lactone ring.

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