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Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products for Caspase

  1. Cat.No. Product Name Information
  2. BCN1552 Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3
  3. BCN2318 Gambogic acid Apoptosis inducer. Activates caspases
  4. BCC1125 Q-VD-OPh hydrateCell-permeable, irreversible pan-caspase inhibitor
  5. BCC1126 Z-VAD-FMKCell-permeable, irreversible caspase inhibitor
  6. BCC1128 Boc-D-FMKPan-caspase inhibitor
  7. BCC1137 Z-DEVD-FMKCaspase-3 inhibitor
  8. BCC1138 Z-VDVAD-FMKCaspase-2 inhibitor
  9. BCC1139 Z-WEHD-FMKCaspase 5 inhibitor,potent,cell-permeable and irreversible
  10. BCC1140 Caspase-3/7 Inhibitor ICaspase-3/7 inhibitor
  11. BCC1143 Apoptosis InhibitorAssociate with caspase-3 inhibition
  12. BCC2099 Apoptosis Activator 2Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
  13. BCC2356 AZ 10417808Selective non-peptide caspase-3 inhibitor
  14. BCC2357 IvachtinCaspase-3 inhibitor
  15. BCC2359 Ac-LEHD-AFCFluorogenic caspase substrate
  16. BCC2360 PETCMActivator of caspase-3
  17. BCC3600 PAC-1Activator of procaspase-3; pro-apoptotic
  18. BCC5116 Z-IETD-FMKCaspase-8 inhibitor
  19. BCC5117 Z-LEHD-FMKIrreversible Caspase-9 inhibitor.
  20. BCC5367 Emricasan

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