Caspase
Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
Products for Caspase
- Cat.No. Product Name Information
- BCN1552 Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3
- BCN2318 Gambogic acid Apoptosis inducer. Activates caspases
- BCC1125 Q-VD-OPh hydrateCell-permeable, irreversible pan-caspase inhibitor
- BCC1126 Z-VAD-FMKCell-permeable, irreversible caspase inhibitor
- BCC1128 Boc-D-FMKPan-caspase inhibitor
- BCC1137 Z-DEVD-FMKCaspase-3 inhibitor
- BCC1138 Z-VDVAD-FMKCaspase-2 inhibitor
- BCC1139 Z-WEHD-FMKCaspase 5 inhibitor,potent,cell-permeable and irreversible
- BCC1140 Caspase-3/7 Inhibitor ICaspase-3/7 inhibitor
- BCC1143 Apoptosis InhibitorAssociate with caspase-3 inhibition
- BCC2099 Apoptosis Activator 2Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
- BCC2356 AZ 10417808Selective non-peptide caspase-3 inhibitor
- BCC2357 IvachtinCaspase-3 inhibitor
- BCC2359 Ac-LEHD-AFCFluorogenic caspase substrate
- BCC2360 PETCMActivator of caspase-3
- BCC3600 PAC-1Activator of procaspase-3; pro-apoptotic
- BCC5116 Z-IETD-FMKCaspase-8 inhibitor
- BCC5117 Z-LEHD-FMKIrreversible Caspase-9 inhibitor.
- BCC5367 Emricasan