14-Deoxy-12-hydroxyandrographolideCAS# 219721-33-2 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 219721-33-2 | SDF | Download SDF |
| PubChem ID | 38350572 | Appearance | Powder |
| Formula | C20H30O5 | M.Wt | 350.45 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[(1S)-2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]-1-hydroxyethyl]-2H-furan-5-one | ||
| SMILES | CC12CCC(C(C1CCC(=C)C2CC(C3=CCOC3=O)O)(C)CO)O | ||
| Standard InChIKey | KHQNSSJNIXVKMK-XWIHJEQYSA-N | ||
| Standard InChI | InChI=1S/C20H30O5/c1-12-4-5-16-19(2,8-6-17(23)20(16,3)11-21)14(12)10-15(22)13-7-9-25-18(13)24/h7,14-17,21-23H,1,4-6,8-11H2,2-3H3/t14-,15+,16+,17-,19+,20+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Targets | Antifection |
14-Deoxy-12-hydroxyandrographolide Dilution Calculator
14-Deoxy-12-hydroxyandrographolide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8535 mL | 14.2674 mL | 28.5347 mL | 57.0695 mL | 71.3369 mL |
| 5 mM | 0.5707 mL | 2.8535 mL | 5.7069 mL | 11.4139 mL | 14.2674 mL |
| 10 mM | 0.2853 mL | 1.4267 mL | 2.8535 mL | 5.7069 mL | 7.1337 mL |
| 50 mM | 0.0571 mL | 0.2853 mL | 0.5707 mL | 1.1414 mL | 1.4267 mL |
| 100 mM | 0.0285 mL | 0.1427 mL | 0.2853 mL | 0.5707 mL | 0.7134 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Baicalin
Catalog No.:BCN5901
CAS No.:21967-41-9
- Griffipavixanthone
Catalog No.:BCN4939
CAS No.:219649-95-3
- (R)-Coclaurine
Catalog No.:BCN8348
CAS No.:2196-60-3
- beta-Hydroxypropiovanillone
Catalog No.:BCN4938
CAS No.:2196-18-1
- 4',7-Dihydroxyflavone
Catalog No.:BCN3758
CAS No.:2196-14-7
- PD 173074
Catalog No.:BCC3662
CAS No.:219580-11-7
- Trans-Pinosylvin dimethyl ether
Catalog No.:BCN3495
CAS No.:21956-56-9
- Littorine
Catalog No.:BCN1917
CAS No.:21956-47-8
- Boc-Cys(Trt)-OH
Catalog No.:BCC3380
CAS No.:21947-98-8
- trans-Cinnamic anhydride
Catalog No.:BCN7914
CAS No.:21947-71-7
- Boc-Nle-OH.DCHA
Catalog No.:BCC3297
CAS No.:21947-32-0
- H-ß-HoIle-OH.HCl
Catalog No.:BCC3235
CAS No.:219310-10-8
- Taxezopidine L
Catalog No.:BCN6946
CAS No.:219749-76-5
- ANA 12
Catalog No.:BCC6287
CAS No.:219766-25-3
- Bombiprenone
Catalog No.:BCN4940
CAS No.:21978-49-4
- BTB06584
Catalog No.:BCC5106
CAS No.:219793-45-0
- Consiculine
Catalog No.:BCN1903
CAS No.:219829-73-9
- Merresectine B
Catalog No.:BCN1918
CAS No.:219829-75-1
- Escitalopram Oxalate
Catalog No.:BCC5040
CAS No.:219861-08-2
- 2,2',3'-Trihydroxy-4,6-dimethoxybenzophenone
Catalog No.:BCN1488
CAS No.:219861-73-1
- MPEP Hydrochloride
Catalog No.:BCC1777
CAS No.:219911-35-0
- 5,8,9,14-Tetraacetoxy-3-benzoyloxy-10,15-dihydroxypepluane
Catalog No.:BCN7657
CAS No.:219916-77-5
- 3-Methyl-1-(2-piperidinophenyl)butylamine N-acetylglutamate salt
Catalog No.:BCC8635
CAS No.:219921-94-5
- Isoescin IA
Catalog No.:BCN2968
CAS No.:219944-39-5
A new diterpene from the leaves of Andrographis paniculata Nees.[Pubmed:22574448]
Nat Prod Commun. 2012 Apr;7(4):485-6.
Phytochemical investigation of the methanolic extract of the leaves of Andrographis paniculata Nees yielded a minor, new diterpene, 21-nor-3,19-isopropylidine-14-deoxy-ent-labda-8(17),13-dien-16,15-olide (1), together with five known labdane type diterpenes, andrographolide 3, 14-deoxyandrographolide 4, 14-Deoxy-12-hydroxyandrographolide 5, 14-deoxy-11,12-dihydroandrographolide 6, neoandrographolide 7, and two acids, cinnamic acid 8, and ferulic acid 9. The chemical structures were established by spectroscopic analyses, including 1D- and 2D-NMR spectroscopic experiments, and on the basis of HR-ESI MS analyses. The methanolic extract of the leaves exhibited moderate antibacterial and antifungal activities at a dose of 200 microg/mL in comparison with the reference standards.
Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts.[Pubmed:22536026]
J Biomed Biotechnol. 2012;2012:876458.
The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 +/- 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 +/- 11.4 beats/minute at this dose. Five labdane diterpenes, 14-Deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.
