1H-Indole-3-carboxylic acidCAS# 771-50-6 |
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| Cas No. | 771-50-6 | SDF | Download SDF |
| PubChem ID | 69867 | Appearance | Powder |
| Formula | C9H7NO2 | M.Wt | 161.2 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1H-indole-3-carboxylic acid | ||
| SMILES | C1=CC=C2C(=C1)C(=CN2)C(=O)O | ||
| Standard InChIKey | KMAKOBLIOCQGJP-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Carpesium abrotanoides
| Description | Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite which belongs to a class of organic compounds known as indolecarboxylic acids and derivatives. |
| Targets | 5-HT Receptor |
| Structure Identification | Bioorg Med Chem Lett. 2008 Jul 15;18(14):3844-7.Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.[Pubmed: 18602261]A novel series of 1H-Indole-3-carboxylic acid pyridine-3-ylamides were synthesized and identified to show high affinity and selectivity for 5-HT(2C) receptor. Among them, 1H-Indole-3-carboxylic acid[6-(2-chloro-pyridin-3-yloxy)-pyridin-3-yl]-amide (15k) exhibits the highest affinity (IC(50)=0.5 nM) with an excellent selectivity (>2000 times) over other serotonin (5-HT(1A), 5-HT(2A), and 5-HT(6)) and dopamine (D(2)-D(4)) receptors. |
1H-Indole-3-carboxylic acid Dilution Calculator
1H-Indole-3-carboxylic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.2035 mL | 31.0174 mL | 62.0347 mL | 124.0695 mL | 155.0868 mL |
| 5 mM | 1.2407 mL | 6.2035 mL | 12.4069 mL | 24.8139 mL | 31.0174 mL |
| 10 mM | 0.6203 mL | 3.1017 mL | 6.2035 mL | 12.4069 mL | 15.5087 mL |
| 50 mM | 0.1241 mL | 0.6203 mL | 1.2407 mL | 2.4814 mL | 3.1017 mL |
| 100 mM | 0.062 mL | 0.3102 mL | 0.6203 mL | 1.2407 mL | 1.5509 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.[Pubmed:18602261]
Bioorg Med Chem Lett. 2008 Jul 15;18(14):3844-7.
A novel series of 1H-Indole-3-carboxylic acid pyridine-3-ylamides were synthesized and identified to show high affinity and selectivity for 5-HT(2C) receptor. Among them, 1H-Indole-3-carboxylic acid[6-(2-chloro-pyridin-3-yloxy)-pyridin-3-yl]-amide (15k) exhibits the highest affinity (IC(50)=0.5 nM) with an excellent selectivity (>2000 times) over other serotonin (5-HT(1A), 5-HT(2A), and 5-HT(6)) and dopamine (D(2)-D(4)) receptors.
Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases.
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