AcetylaconitineCAS# 77181-26-1 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 77181-26-1 | SDF | Download SDF |
| PubChem ID | 54249 | Appearance | Cryst. |
| Formula | C36H49NO12 | M.Wt | 687.78 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | Acetylaconitine; 3-Acetylaconitine | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC[NH+]1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)OC(=O)C)OC)OC)OC(=O)C)COC.[Br-] | ||
| Standard InChIKey | SPAMTIDCTYPTMV-MZJISZQOSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 3-Acetylaconitine, aconitine, and deoxyaconitine are main toxic components of the roots of Aconitum pendulum. |
| Structure Identification | Zhongguo Zhong Yao Za Zhi. 2010 Mar;35(5):588-92.Study on processing principle of Aconitum pendulum.[Pubmed: 20506817]To study the processing principles of different processed products of Aconitum pendulum. |
Acetylaconitine Dilution Calculator
Acetylaconitine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.454 mL | 7.2698 mL | 14.5395 mL | 29.0791 mL | 36.3488 mL |
| 5 mM | 0.2908 mL | 1.454 mL | 2.9079 mL | 5.8158 mL | 7.2698 mL |
| 10 mM | 0.1454 mL | 0.727 mL | 1.454 mL | 2.9079 mL | 3.6349 mL |
| 50 mM | 0.0291 mL | 0.1454 mL | 0.2908 mL | 0.5816 mL | 0.727 mL |
| 100 mM | 0.0145 mL | 0.0727 mL | 0.1454 mL | 0.2908 mL | 0.3635 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Flaconitine is isolated from the ammonium hydroxide wetted root of A.szechenyianum Gay. Flaconitine is considered to be a NF-κB inhibitor.
In Vitro:Flaconitine has been demonstrated to suppress TNF-α induced NF-κB activation and is considered as a diester-diterpenoid-type NF-κB inhibitor[1] Flaconitine (3-Acetylaconitine) is evaluated for its cytotoxic activity against human leukemic P388 cells using the SRB (Sulforhodamine B) method, with Etoposide as the positive control. The cell growth inhibitory potency of Flaconitine is expressed as IC50 (μM) Value. Flaconitine exhibits moderately cytotoxic activity with an IC50 of 18.6 μM[2].
References:
[1]. Dong L, et al. Identification of nuclear factor-κB inhibitors and β2 adrenergic receptor agonists in Chinese medicinal preparation Fuzilizhong pills using UPLC with quadrupole time-of-flight MS. Phytochem Anal. 2014 Mar-Apr;25(2):113-21.
[2]. He YQ, et al. Diterpenoid alkaloids from a Tibetan medicinal plant Aconitum richardsonianum var. pseudosessiliflorum and their cytotoxic activity. J Pharm Anal. 2011 Feb;1(1):57-59.
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[Study on processing principle of Aconitum pendulum].[Pubmed:20506817]
Zhongguo Zhong Yao Za Zhi. 2010 Mar;35(5):588-92.
OBJECTIVE: To study the processing principles of different processed products of Aconitum pendulum. METHOD: Using high performance liquid chromatography and acute toxicity test to compare the changes in chemical composition and toxicity of the roots and processed products of A. pendulum. RESULT: The main toxic components of the roots of A. pendulum were aconitine, deoxyaconitine and 3-Acetylaconitine. The contents of these three alkaloids were significantly reduced in processed products, while benzoylaconitine significantly increased. In addition, processed products emerged aconine, polyschistine-D, beyzoyldeoxyaconine, 16-epi-pyroaconitine and 16-epi-pyrodeoxyaconitine. From the structural analysis, these new emerged compounds transformed from the aconitine, deoxyaconitine and 3-Acetylaconitine. CONCLUSION: Different processing methods can reduce the toxicity of the roots of A. pendulum. Processing principle is ester hydrolysis and high-temperature pyrolysis.
