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2-Amino-3-benzyloxypyridine

CAS# 24016-03-3

2-Amino-3-benzyloxypyridine

Catalog No. BCC8524----Order now to get a substantial discount!

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2-Amino-3-benzyloxypyridine: 5mg $17 In Stock
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Chemical structure

2-Amino-3-benzyloxypyridine

3D structure

Chemical Properties of 2-Amino-3-benzyloxypyridine

Cas No. 24016-03-3 SDF Download SDF
PubChem ID 90334 Appearance Powder
Formula C12H12N2O M.Wt 200
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-phenylmethoxypyridin-2-amine
SMILES C1=CC=C(C=C1)COC2=C(N=CC=C2)N
Standard InChIKey NMCBWICNRJLKKM-UHFFFAOYSA-N
Standard InChI InChI=1S/C12H12N2O/c13-12-11(7-4-8-14-12)15-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,13,14)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

2-Amino-3-benzyloxypyridine Dilution Calculator

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2-Amino-3-benzyloxypyridine Molarity Calculator

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Preparing Stock Solutions of 2-Amino-3-benzyloxypyridine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5 mL 25 mL 50 mL 100 mL 125 mL
5 mM 1 mL 5 mL 10 mL 20 mL 25 mL
10 mM 0.5 mL 2.5 mL 5 mL 10 mL 12.5 mL
50 mM 0.1 mL 0.5 mL 1 mL 2 mL 2.5 mL
100 mM 0.05 mL 0.25 mL 0.5 mL 1 mL 1.25 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2-Amino-3-benzyloxypyridine

Rapid identification of ligand-binding sites by using an assignment-free NMR approach.[Pubmed:24171460]

J Med Chem. 2013 Nov 27;56(22):9342-50.

In this study, we developed an assignment-free approach for rapid identification of ligand-binding sites in target proteins by using NMR. With a sophisticated cell-free stable isotope-labeling procedure that introduces (15)N- or (13)C-labels to specific atoms of target proteins, this approach requires only a single series of ligand titrations with labeled targets. Using titration data, ligand-binding sites in the target protein can be identified without time-consuming assignment procedures. We demonstrated the feasibility of this approach by using structurally well-characterized interactions between mitogen-activated protein (MAP) kinase p38alpha and its inhibitor 2-Amino-3-benzyloxypyridine. Furthermore, we confirmed the recently proposed fatty acid binding to p38alpha and confirmed the fatty acid-binding site in the MAP kinase insert region.

Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.[Pubmed:15658855]

J Med Chem. 2005 Jan 27;48(2):414-26.

We describe the structure-guided optimization of the molecular fragments 2-Amino-3-benzyloxypyridine 1 (IC(50) 1.3 mM) and 3-(2-(4-pyridyl)ethyl)indole 2 (IC(50) 35 microM) identified using X-ray crystallographic screening of p38alpha MAP kinase. Using two separate case studies, the article focuses on the key compounds synthesized, the structure-activity relationships and the binding mode observations made during this optimization process, resulting in two potent lead series that demonstrate significant increases in activity. We describe the process of compound elaboration either through the growing out from fragments into adjacent pockets or through the conjoining of overlapping fragments and demonstrate that we have exploited the mobile conserved activation loop, consisting in part of Asp168-Phe169-Gly170 (DFG), to generate significant improvements in potency and kinase selectivity.

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