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2'-Hydroxy-3',4',6'-trimethoxychalcone

CAS# 91856-16-5

2'-Hydroxy-3',4',6'-trimethoxychalcone

Catalog No. BCN0522----Order now to get a substantial discount!

Product Name & Size Price Stock
2'-Hydroxy-3',4',6'-trimethoxychalcone: 5mg $725 In Stock
2'-Hydroxy-3',4',6'-trimethoxychalcone: 10mg Please Inquire In Stock
2'-Hydroxy-3',4',6'-trimethoxychalcone: 20mg Please Inquire Please Inquire
2'-Hydroxy-3',4',6'-trimethoxychalcone: 50mg Please Inquire Please Inquire
2'-Hydroxy-3',4',6'-trimethoxychalcone: 100mg Please Inquire Please Inquire
2'-Hydroxy-3',4',6'-trimethoxychalcone: 200mg Please Inquire Please Inquire
2'-Hydroxy-3',4',6'-trimethoxychalcone: 500mg Please Inquire Please Inquire
2'-Hydroxy-3',4',6'-trimethoxychalcone: 1000mg Please Inquire Please Inquire

Quality Control of 2'-Hydroxy-3',4',6'-trimethoxychalcone

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Chemical structure

2'-Hydroxy-3',4',6'-trimethoxychalcone

3D structure

Chemical Properties of 2'-Hydroxy-3',4',6'-trimethoxychalcone

Cas No. 91856-16-5 SDF Download SDF
PubChem ID 227450 Appearance Orange powder
Formula C18H18O5 M.Wt 314.3
Type of Compound Chalcones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-phenylprop-2-en-1-one
SMILES COC1=CC(=C(C(=C1C(=O)C=CC2=CC=CC=C2)O)OC)OC
Standard InChIKey OCGIXADHTXAPKN-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H18O5/c1-21-14-11-15(22-2)18(23-3)17(20)16(14)13(19)10-9-12-7-5-4-6-8-12/h4-11,20H,1-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

2'-Hydroxy-3',4',6'-trimethoxychalcone Dilution Calculator

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2'-Hydroxy-3',4',6'-trimethoxychalcone Molarity Calculator

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Preparing Stock Solutions of 2'-Hydroxy-3',4',6'-trimethoxychalcone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2'-Hydroxy-3',4',6'-trimethoxychalcone

Flavonoid, stilbene and diarylheptanoid constituents of Persicaria maculosa Gray and cytotoxic activity of the isolated compounds.[Pubmed:32433929]

Fitoterapia. 2020 Sep;145:104610.

Persicaria maculosa (Polygonaceae) has been used as edible and as medicinal plant since ancient times. As a result of multistep chromatographic purifications, chalcones [2'-hydroxy-3',4',6'-trimethoxychalcone (1), pashanone (2), pinostrobin chalcone (3)], flavanones [6-hydroxy-5,7-dimethoxyflavanone (4), pinostrobin (5), onysilin (6), 5-hydroxy-7,8-dimethoxyflavanone (7)], flavonol [3-O-methylgalangin (8)], stilbene [persilben (9)], diarylheptanoids [1,7-diphenylhept-4-en-3-one (10), dihydroyashabushiketol (12), yashabushidiol B (13)] and 3-oxo-alpha-ionol-glucoside (11) were isolated from P. maculosa. The present paper reports for the first time the occurrence of diarylheptanoid-type constituents in the family Polygonaceae. Cytotoxicity of 1-5, 7 and 9-11 on 4 T1 mouse triple negative breast cancer cells was assayed by MTT test. None of the tested compounds reduced the cell viability to less than 80% of the control. On non-tumorigenic D3 human brain endothelial cells the decrease of cell viability was observed in case of 1 and 2. Further impedance measurements on 4 T1 and D3 cells a concentration-dependent decrease in the cell index of both cell types was demonstrated for 1, while 2 proved to be toxic only on endothelial cells.

Hydroxyespintanol and schefflerichalcone: two new compounds from Uvaria scheffleri.[Pubmed:19756918]

J Nat Med. 2010 Jan;64(1):75-9.

A chemical investigation of the petroleum ether extract and chloroform extract of the root of Uvaria scheffleri Diels (Annonaceae) led to the isolation of two new compounds, named hydroxyespintanol (1) and schefflerichalcone (2), together with eight known compounds (3-10). The structural elucidation of compounds 1 and 2 by spectroscopic studies is described. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60 cells was studied. Among these, 2'-hydroxy-3',4',6'-trimethoxychalcone (5) exhibited cytotoxicity (IC(50) 12 microM), and espintanol (3), which was the main ingredient, also showed some cytotoxicity (IC(50) 44 microM).

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