Alpinin BCAS# 2125947-85-3 |
Quality Control & MSDS
Package In Stock
Number of papers citing our products
| Cas No. | 2125947-85-3 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Oil |
| Formula | C20H26O7 | M.Wt | 378.4 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Alpinin B Dilution Calculator
Alpinin B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6427 mL | 13.2135 mL | 26.4271 mL | 52.8541 mL | 66.0677 mL |
| 5 mM | 0.5285 mL | 2.6427 mL | 5.2854 mL | 10.5708 mL | 13.2135 mL |
| 10 mM | 0.2643 mL | 1.3214 mL | 2.6427 mL | 5.2854 mL | 6.6068 mL |
| 50 mM | 0.0529 mL | 0.2643 mL | 0.5285 mL | 1.0571 mL | 1.3214 mL |
| 100 mM | 0.0264 mL | 0.1321 mL | 0.2643 mL | 0.5285 mL | 0.6607 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Diarylheptanoids from Rhizomes of Alpinia officinarum Inhibit Aggregation of alpha-Synuclein.[Pubmed:28707886]
J Agric Food Chem. 2017 Aug 9;65(31):6608-6614.
Two new diarylheptanoids, alpinin A (1) and Alpinin B (2), together with 18 known diarylheptanoids (3-20), were isolated from the rhizomes of Alpinia officinarum. Their structures were elucidated by comprehensive spectroscopic analysis, including high-resolution mass spectrometry, infrared spectroscopy, and one- and two-dimensional nuclear magnetic resonance spectroscopy. Structurally, alpinin A is a new member of the small family of oxa-bridged diarylheptanoids and contains the characteristic 2,6-cis-configured tetrahydropyran motif (C1-C5 oxa bridge). The absolute configuration of alpinin A was confirmed by asymmetric total synthesis of the enantiomer (ent-1), corroborating the assignment of the molecular structure. The absolute configuration of Alpinin B was determined on the basis of the analysis of the circular dichroism exciton chirality spectrum. We evaluated the inhibitory activity of all isolated diarylheptanoids against alpha-synuclein aggregation at 10 muM. Alpinins A and B significantly inhibited alpha-synuclein aggregation by 66 and 67%, respectively.
A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum.[Pubmed:24636065]
Chin J Nat Med. 2014 Feb;12(2):139-41.
AIM: To study the chemical constituents of the rhizomes of Alpinia officinarum Hance. METHOD: Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay. RESULTS: A dimeric diarylheptanoid, named Alpinin B (1), along with three known diarylheptanoids were obtained, and their structures were identified as Alpinin B (1), 1, 7-diphenyl-3,5-heptanedione (2), (4E)-1, 7-diphenylhept-4-en-3-one (3) and (4E)-7- (4-hydroxyphenyl)-1-phenylhept-4-en-3-one (4). CONCLUSION: Compound 1 is a new dimeric diarylheptanoid. The biosynthetic pathway of 1 was speculated to originate from a Michael reaction between compounds 2 and 3. Compound 3 showed cytotoxicity against the human glioblastoma T98G cell line with IC50 of 27 mumol.L(-1).
