Home >> Research Area >>Vitamin D Related>>VD/VDR>> 24, 25-Dihydroxy VD3

24, 25-Dihydroxy VD3

Vitamin D analogue CAS# 40013-87-4

24, 25-Dihydroxy VD3

Catalog No. BCC1303----Order now to get a substantial discount!

Product Name & Size Price Stock
24, 25-Dihydroxy VD3: 5mg $4497 In Stock
24, 25-Dihydroxy VD3: 10mg Please Inquire In Stock
24, 25-Dihydroxy VD3: 20mg Please Inquire Please Inquire
24, 25-Dihydroxy VD3: 50mg Please Inquire Please Inquire
24, 25-Dihydroxy VD3: 100mg Please Inquire Please Inquire
24, 25-Dihydroxy VD3: 200mg Please Inquire Please Inquire
24, 25-Dihydroxy VD3: 500mg Please Inquire Please Inquire
24, 25-Dihydroxy VD3: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of 24, 25-Dihydroxy VD3

Number of papers citing our products

Chemical structure

24, 25-Dihydroxy VD3

3D structure

Chemical Properties of 24, 25-Dihydroxy VD3

Cas No. 40013-87-4 SDF Download SDF
PubChem ID 6434253 Appearance Powder
Formula C27H44O3 M.Wt 416.64
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO
Chemical Name (6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol
SMILES CC(CCC(C(C)(C)O)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
Standard InChIKey FCKJYANJHNLEEP-SRLFHJKTSA-N
Standard InChI InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25?,27-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

24, 25-Dihydroxy VD3 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

24, 25-Dihydroxy VD3 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 24, 25-Dihydroxy VD3

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4002 mL 12.0008 mL 24.0015 mL 48.0031 mL 60.0038 mL
5 mM 0.48 mL 2.4002 mL 4.8003 mL 9.6006 mL 12.0008 mL
10 mM 0.24 mL 1.2001 mL 2.4002 mL 4.8003 mL 6.0004 mL
50 mM 0.048 mL 0.24 mL 0.48 mL 0.9601 mL 1.2001 mL
100 mM 0.024 mL 0.12 mL 0.24 mL 0.48 mL 0.6 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on 24, 25-Dihydroxy VD3

24, 25-Dihydroxy VD3 is a compound which is closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydroxyvitamin D3 is inactive as a hormone both in vitro and in vivo.

References:
[1]. Takayama H. Creation of functional organic compounds and their applicationsYakugaku Zasshi. 2002 Feb;122(2):127-55. [2]. Kim YR, Abraham NG, Lutton JD. Mechanisms of differentiation of U937 leukemic cells induced by GM-CSF and 1,25(OH)2 vitamin D3. Leuk Res. 1991;15(6):409-18. [3]. Dennis Wagner, Heather E. Hanwell, Kareena Schnabl et al. The ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 is predictive of 25-hydroxyvitamin D3 response to vitamin D3 supplementation. The Journal of Steroid Biochemistry and Molecular Biology.Volume 126, Issues 3-5, September 2011, Pages 72-77

Featured Products
New Products
 

References on 24, 25-Dihydroxy VD3

[Creation of functional organic compounds and their applications].[Pubmed:11857955]

Yakugaku Zasshi. 2002 Feb;122(2):127-55.

Our studies on creation of functional organic compounds and their applications, have focused on three areas, namely, (A) organic chemical studies on VD (vitamin D) analogues, (B) studies on solitary wasp venoms, and (C) studies on functional building blocks for organic synthesis. In the first area, several novel and important vitamin D analogues were synthesized and biologically evaluated, and their high VDR (vitamin D receptor) binding affinities were discussed on the basis of conformational analysis and docking study by Molecular Mechanics Calculation to the LBD (ligand binding domain) of VDR: These compounds include 24,24-difluoro-1 alpha,25-dihydroxy-VD3 (2) (an antimetabolism agent, the first VD analogue having higher potency than the natural hormone (1)), 2 alpha-methyl-1 alpha,25-dihydroxy-VD3 (42b) (the first A-ring-modified VD analogue exhibiting stronger VDR affinity than 1) and its 20-epimer (43b) (a VD analogue having a highest HL-60 cell differentiation inducing activity with a relatively low calcemic effect), and 2 alpha-(omega-hydroxypropyl)-1 alpha,25-dihydroxy-VD3 (exceptionally high calcemic effect). In the second area, we isolated and determined the structure of pompilidotoxins (76, 77), novel peptide neurotoxins in solitary wasp venoms. In the third area, we created furan-fused 3-sulfolene, 4H, 6H-thieno [3,4-c]-furan 5,5-dioxide and pyrrole-fused 3-sulfolene (96), 3,5-dihydro-1H-thieno[3,4-c] pyrrole 2,2-dioxide (125), and studied their inter- and intramolecular Diels-Alder reactions.

Mechanisms of differentiation of U937 leukemic cells induced by GM-CSF and 1,25(OH)2 vitamin D3.[Pubmed:1861527]

Leuk Res. 1991;15(6):409-18.

The human monoblast cell line, U937, was employed to elucidate early events associated with differentiation induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) and 1,25-dihydroxy-Vitamin D3 (VD3). Exposure of cells to a combination of GM-CSF and VD3 resulted in an up-regulation of c-fos mRNA within 1 h and a marked down-regulation of c-myc mRNA by 24 h and this was associated with a shift of cell population from the S phase to the G0 + G1 phase of the cell cycle by 18%. This was followed by a marked enhancement of monocyte-associated cell surface antigens [OKM1 (CD11b), LeuM3 (CD14), M77.7], as determined by monoclonal antibodies and flow cytometry. Functional characteristics such as nitroblue-tetrazolium reduction, alpha-naphthyl butyrate esterase activity, and phagocytic capability occurred. Cells treated with GM-CSF or VD3 alone showed only minor changes. These results demonstrate a potent synergistic effect of GM-CSF and VD3 on induction of U937 differentiation. This differentiation was partially blocked by H7, a protein kinase C (PKC) inhibitor. Changes in c-myc and c-fos mRNA expressions and a shift in cell cycle were shown to be early events in this process.

Description

24, 25-Dihydroxy VD3 is a compound which is closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydroxyvitamin D3 is inactive as a hormone both in vitro and in vivo.

Keywords:

24, 25-Dihydroxy VD3,40013-87-4,Natural Products,VD/VDR, buy 24, 25-Dihydroxy VD3 , 24, 25-Dihydroxy VD3 supplier , purchase 24, 25-Dihydroxy VD3 , 24, 25-Dihydroxy VD3 cost , 24, 25-Dihydroxy VD3 manufacturer , order 24, 25-Dihydroxy VD3 , high purity 24, 25-Dihydroxy VD3

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: