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20-Hydroxyganoderic acid G

CAS# 400604-12-8

20-Hydroxyganoderic acid G

2D Structure

Catalog No. BCN8231----Order now to get a substantial discount!

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20-Hydroxyganoderic acid G: 5mg $322 In Stock
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Quality Control of 20-Hydroxyganoderic acid G

3D structure

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20-Hydroxyganoderic acid G

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Chemical Properties of 20-Hydroxyganoderic acid G

Cas No. 400604-12-8 SDF Download SDF
PubChem ID 134715238 Appearance Powder
Formula C30H44O9 M.Wt 548.67
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (6S)-6-hydroxy-2-methyl-4-oxo-6-[(3S,7S,10S,12S,13R,14R,17S)-3,7,12-trihydroxy-4,4,10,13,14-pentamethyl-11,15-dioxo-2,3,5,6,7,12,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]heptanoic acid
SMILES CC(CC(=O)CC(C)(C1CC(=O)C2(C1(C(C(=O)C3=C2C(CC4C3(CCC(C4(C)C)O)C)O)O)C)C)O)C(=O)O
Standard InChIKey HHCQRNABFNZPFW-PVWQPZRVSA-N
Standard InChI InChI=1S/C30H44O9/c1-14(25(37)38)10-15(31)13-28(5,39)18-12-20(34)30(7)21-16(32)11-17-26(2,3)19(33)8-9-27(17,4)22(21)23(35)24(36)29(18,30)6/h14,16-19,24,32-33,36,39H,8-13H2,1-7H3,(H,37,38)/t14?,16-,17?,18+,19-,24+,27-,28-,29-,30-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 20-Hydroxyganoderic acid G

The fruit body of Ganoderma lucidum

Protocol of 20-Hydroxyganoderic acid G

Structure Identification
Journal of Natural Products, 2002, 65(1):72-75.

New lanostanoids from the mushroom Ganoderma lucidum.[Reference: WebLink]


METHODS AND RESULTS:
From a lipophilic extract of the fruiting body of Ganoderma lucidum, three new lanostanoids, 8beta,9alpha-dihydroganoderic acid J (1), methyl 8beta,9alpha-dihydroganoderate J (2), and 20-Hydroxyganoderic acid G (3), along with 12 known lanostanoids and two ergostane sterols were isolated.
CONCLUSIONS:
The structures of 1-3 were determined by interpretation of their spectroscopic data.

20-Hydroxyganoderic acid G Dilution Calculator

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20-Hydroxyganoderic acid G Molarity Calculator

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Preparing Stock Solutions of 20-Hydroxyganoderic acid G

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8226 mL 9.1129 mL 18.2259 mL 36.4518 mL 45.5647 mL
5 mM 0.3645 mL 1.8226 mL 3.6452 mL 7.2904 mL 9.1129 mL
10 mM 0.1823 mL 0.9113 mL 1.8226 mL 3.6452 mL 4.5565 mL
50 mM 0.0365 mL 0.1823 mL 0.3645 mL 0.729 mL 0.9113 mL
100 mM 0.0182 mL 0.0911 mL 0.1823 mL 0.3645 mL 0.4556 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Description

20-Hydroxyganoderic Acid G is a lanostane triterpenoid obtained from the EtOH extract of fruiting bodies of the Ganoderma curtisii. 20-Hydroxyganoderic Acid G inhibits BV-2 microglia cells activated by LPS with an IC50 of 21.33 μM. 20-Hydroxyganoderic Acid G has therapeutic potential in the drug discovery of nerve inflammation diseases associated with microglia activated by LPS.

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