Home >> Research Area >>Natural Products>>Phenols>> p-Hydroxy-5,6-dehydrokawain

p-Hydroxy-5,6-dehydrokawain

CAS# 39986-86-2

p-Hydroxy-5,6-dehydrokawain

2D Structure

Catalog No. BCN3597----Order now to get a substantial discount!

Product Name & Size Price Stock
p-Hydroxy-5,6-dehydrokawain: 5mg $725 In Stock
p-Hydroxy-5,6-dehydrokawain: 10mg Please Inquire In Stock
p-Hydroxy-5,6-dehydrokawain: 20mg Please Inquire Please Inquire
p-Hydroxy-5,6-dehydrokawain: 50mg Please Inquire Please Inquire
p-Hydroxy-5,6-dehydrokawain: 100mg Please Inquire Please Inquire
p-Hydroxy-5,6-dehydrokawain: 200mg Please Inquire Please Inquire
p-Hydroxy-5,6-dehydrokawain: 500mg Please Inquire Please Inquire
p-Hydroxy-5,6-dehydrokawain: 1000mg Please Inquire Please Inquire

Quality Control of p-Hydroxy-5,6-dehydrokawain

3D structure

Package In Stock

p-Hydroxy-5,6-dehydrokawain

Number of papers citing our products

Chemical Properties of p-Hydroxy-5,6-dehydrokawain

Cas No. 39986-86-2 SDF Download SDF
PubChem ID 10243535 Appearance Powder
Formula C14H12O4 M.Wt 244.2
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 6-[(E)-2-(4-hydroxyphenyl)ethenyl]-4-methoxypyran-2-one
SMILES COC1=CC(=O)OC(=C1)C=CC2=CC=C(C=C2)O
Standard InChIKey VWYHYOYHRIWSJU-QPJJXVBHSA-N
Standard InChI InChI=1S/C14H12O4/c1-17-13-8-12(18-14(16)9-13)7-4-10-2-5-11(15)6-3-10/h2-9,15H,1H3/b7-4+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of p-Hydroxy-5,6-dehydrokawain

The roots of Piper methysticum Forst

Biological Activity of p-Hydroxy-5,6-dehydrokawain

Description4'-Hydroxy-5,6-dehydrokawain shows significant antiproliferative activity against murine colon 26-L5 carcinoma.
In vitro

Six new diarylheptanoids from the seeds of Alpinia blepharocalyx.[Reference: WebLink]

Journal of Natural Products, 2001, 64(3):289-293.


METHODS AND RESULTS:
Chromatographic separation of part of an EtOH extract of the seeds of Alpinia blepharocalyx resulted in the isolation of six new (1-6) and two known (7, 8) diarylheptanoids together with 12 known compounds. The structures of the new compounds, including their absolute stereochemistry, were elucidated by spectroscopic and chemical methods as (3S,5S)- (1) and (3S,5R)-3-hydroxy-5-methoxy-1-(4-hydroxyphenyl)-7-phenyl-6E-heptene (2), (3S,5S)- (3) and (3S,5R)-3-hydroxy-5-ethoxy-1-(4-hydroxyphenyl)-7-phenyl-6E-heptene (4), (3S)-methoxy-1,7-bis(4-hydroxyphenyl)-6E-hepten-5-one (5), and 1,7-bis(4-hydroxyphenyl)hepta-4E,6E-dien-3-one (6).
CONCLUSIONS:
Among the isolated compounds, 5, (3S,5S)-3,5-dihydroxy-1,7-bis(4-hydroxyphenyl)heptane (8), 4'-hydroxy-5,6-dehydrokawain (p-Hydroxy-5,6-dehydrokawain,14), and/or phloroglucinol (20) showed significant antiproliferative activity against murine colon 26-L5 carcinoma (ED(50): 5, 5.2 microM; 8, 12.8 microM; 14, 20.7 microM; 20, 26.4 microM) and human HT-1080 fibrosarcoma (ED(50): 5, 10.1 microM; 14, 20.1 microM; 20, 20.9 microM) cells.

p-Hydroxy-5,6-dehydrokawain Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

p-Hydroxy-5,6-dehydrokawain Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of p-Hydroxy-5,6-dehydrokawain

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.095 mL 20.475 mL 40.95 mL 81.9001 mL 102.3751 mL
5 mM 0.819 mL 4.095 mL 8.19 mL 16.38 mL 20.475 mL
10 mM 0.4095 mL 2.0475 mL 4.095 mL 8.19 mL 10.2375 mL
50 mM 0.0819 mL 0.4095 mL 0.819 mL 1.638 mL 2.0475 mL
100 mM 0.041 mL 0.2048 mL 0.4095 mL 0.819 mL 1.0238 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on p-Hydroxy-5,6-dehydrokawain

Synthesis of novel 5,6-dehydrokawain analogs as osteogenic inducers and their action mechanisms.[Pubmed:28427810]

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2401-2406.

An imbalance between bone resorption by osteoclasts and bone formation by osteoblasts can cause bone loss and bone-related disease. In a previous search for natural products that increase osteogenic activity, we found that 5,6-dehydrokawain (1) from Alpinia zerumbet promotes osteoblastogenesis. In this study, we synthesized and evaluated series of 5,6-dehydrokawain analogs. Our structure-activity relationships revealed that alkylation of para or meta position of aromatic ring of 1 promote osteogenic activity. Among the potential analogs we synthesized, (E)-6-(4-Ethylstyryl)-4-methoxy-2H-pyran-2-one (14) and (E)-6-(4-Butylstyryl)-4-methoxy-2H-pyran-2-one (21) both significantly up-regulated Runx2 and Osterix mRNA expression at 10microM. These osteogenic activities could be mediated by bone morphogenetic protein (BMP) and activation of p38 MAPK signaling pathways. Compounds 14 and 21 also inhibited RANKL-induced osteoclast differentiation of RAW264 cells. These results indicated that novel 5,6-dehydrokawain analogs not only increase osteogenic activity but also inhibit osteoclast differentiation, and could be potential lead compounds for the development of anti-osteoporosis agents.

Syntheses and biological activities of dihydro-5,6-dehydrokawain derivatives.[Pubmed:8987662]

Biosci Biotechnol Biochem. 1996 Oct;60(10):1643-5.

The syntheses and biological activities of dihydro-5,6-dehydrokawain derivatives against plant pathogenic fungi and termites were investigated. Dihydro-5,6-dehydrokawain was isolated by a simple method without chromatography from the leaves of Alpinia speciosa K. SCHUM. The white crystalline compound obtained was identified as dihydro-5,6-dehydrokawain (1) by instrumental analyses. 4-Hydroxy-6-(2-phenylethyl)-2H-pyran-2-one (3) was prepared by hydrolyzing dihydro-5,6-dehydrokawain. Three dihydro-5,6-dehydrokawain derivatives were synthesized by reacting 3 with phosphoric agents. Among the synthesized compounds, dimethyl [6-(2-phenylethyl)-2-oxo-2H-pyran-4-yl]phosphorothionate (4) had the strongest antifungal activity of 91% at 100 ppm against Corticium rolfsii.

5,6-Dehydrokawain from Alpinia zerumbet promotes osteoblastic MC3T3-E1 cell differentiation.[Pubmed:26940726]

Biosci Biotechnol Biochem. 2016 Jul;80(7):1425-32.

Bone homeostasis is maintained by balancing bone formation and bone resorption, but an imbalance between them is associated with various bone-related diseases such as osteoporosis and rheumatoid arthritis. We found that 5,6-dehydrokawain (DK) and dihydro-5,6-dehydrokawain (DDK), which were isolated as promising compounds from Alpinia zerumbet rhizomes, promote differentiation of osteoblastic MC3T3-E1 cells. DK and DDK increased the alkaline phosphatase activity and matrix mineralization of MC3T3-E1 cells. DK exerts larger effects than DDK. The gene expression of runt-related transcription factor 2 and osterix, which are essential transcription factors in the early period of osteoblast differentiation, was significantly increased by DK treatment. The mRNA level of distal-less homeobox 5 was also enhanced by DK treatment, and DK activated the p38 mitogen-activated protein kinase pathway. Therefore, DK may have clinical potential for preventing osteoporosis, and could be considered as a potential anabolic therapeutic agent.

Keywords:

p-Hydroxy-5,6-dehydrokawain,39986-86-2,Natural Products, buy p-Hydroxy-5,6-dehydrokawain , p-Hydroxy-5,6-dehydrokawain supplier , purchase p-Hydroxy-5,6-dehydrokawain , p-Hydroxy-5,6-dehydrokawain cost , p-Hydroxy-5,6-dehydrokawain manufacturer , order p-Hydroxy-5,6-dehydrokawain , high purity p-Hydroxy-5,6-dehydrokawain

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: