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3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

CAS# 870456-88-5

3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

Catalog No. BCN1322----Order now to get a substantial discount!

Product Name & Size Price Stock
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid: 5mg Please Inquire In Stock
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid: 10mg Please Inquire In Stock
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid: 20mg Please Inquire Please Inquire
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid: 50mg Please Inquire Please Inquire
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid: 100mg Please Inquire Please Inquire
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid: 200mg Please Inquire Please Inquire
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid: 500mg Please Inquire Please Inquire
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid: 1000mg Please Inquire Please Inquire

Quality Control of 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

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Chemical structure

3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

3D structure

Chemical Properties of 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

Cas No. 870456-88-5 SDF Download SDF
PubChem ID 21593999 Appearance Powder
Formula C30H44O4 M.Wt 468.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(CC(=O)C=C(C)C(=O)O)C1CCC2(C1(CCC34C2CCC5C3(C4)CCC(=O)C5(C)C)C)C
Standard InChIKey PJYWFBGSJPGTAM-ACKRQZOBSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

The roots of Pseudolarix kaempferi

Biological Activity of 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

Description1. 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid inhibits the MRCKα kinase with Kd50 of 3.0 uM, it also inhibits the MRCKβ kinase with Kd50 of 3.2 uM; the role of Kinases in cancer onset and progression has made kinases a target for the control of some cancers, suggests that it may possess anticancer activity.

3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid Dilution Calculator

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3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid Molarity Calculator

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Preparing Stock Solutions of 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1336 mL 10.6678 mL 21.3356 mL 42.6712 mL 53.339 mL
5 mM 0.4267 mL 2.1336 mL 4.2671 mL 8.5342 mL 10.6678 mL
10 mM 0.2134 mL 1.0668 mL 2.1336 mL 4.2671 mL 5.3339 mL
50 mM 0.0427 mL 0.2134 mL 0.4267 mL 0.8534 mL 1.0668 mL
100 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.4267 mL 0.5334 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

Cycloartane anticancer activity

Cancer Res., 2014, 74(19 ):1754-1754.

Cycloart-23-ene-3,25-diol (1), Cycloartane-3,24,25-triol (2), Cycloart-25-ene-3,24-diol (3), 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid (4), 24,25-Dihydroxycycloartan-3-one (5) inhibited the MRCKα kinase with Kd of 0.21 μM, 0.25μM, 0.36 μM, 3.0 μM, and 2.1 μM respectively. Hydroxycycloart-23-en-3-one,25, (6) showed no inhibition against the MRCKα kinase. Compounds 1, 3, 4, 5 inhibited the MRCKβ kinase with Kd of 4.7 μM, 1.10 μM, 3.2 μM, and 9.8 μM, respectively. Three of the six cycloartanes exhibited antiproliferation activity against two prostate and breast cancer cell lines each.In conclusion, cycloart-23-ene-3,25-diol (1) showed the most promising activity against the MRCKα/β kinase out of the 6 cycloartanes screened demonstrating an interesting structure activity relationship profile when compared with the other molecules. Cycloart-23-ene-3,25-diol (1) deserves further studies to determine its in vivo efficacy and safety.

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