Home >> Research Area >>Natural Products>>Flavonoids>> 4',6,7-Trimethoxyisoflavone

4',6,7-Trimethoxyisoflavone

CAS# 798-61-8

4',6,7-Trimethoxyisoflavone

Catalog No. BCN9982----Order now to get a substantial discount!

Product Name & Size Price Stock
4',6,7-Trimethoxyisoflavone: 5mg Please Inquire In Stock
4',6,7-Trimethoxyisoflavone: 10mg Please Inquire In Stock
4',6,7-Trimethoxyisoflavone: 20mg Please Inquire Please Inquire
4',6,7-Trimethoxyisoflavone: 50mg Please Inquire Please Inquire
4',6,7-Trimethoxyisoflavone: 100mg Please Inquire Please Inquire
4',6,7-Trimethoxyisoflavone: 200mg Please Inquire Please Inquire
4',6,7-Trimethoxyisoflavone: 500mg Please Inquire Please Inquire
4',6,7-Trimethoxyisoflavone: 1000mg Please Inquire Please Inquire

Quality Control of 4',6,7-Trimethoxyisoflavone

Number of papers citing our products

Chemical structure

4',6,7-Trimethoxyisoflavone

3D structure

Chemical Properties of 4',6,7-Trimethoxyisoflavone

Cas No. 798-61-8 SDF Download SDF
PubChem ID 688655 Appearance Powder
Formula C18H16O5 M.Wt 312.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 6,7-dimethoxy-3-(4-methoxyphenyl)chromen-4-one
SMILES COC1=CC=C(C=C1)C2=COC3=CC(=C(C=C3C2=O)OC)OC
Standard InChIKey YHXIOAVHEXKZCQ-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H16O5/c1-20-12-6-4-11(5-7-12)14-10-23-15-9-17(22-3)16(21-2)8-13(15)18(14)19/h4-10H,1-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 4',6,7-Trimethoxyisoflavone

The rhizomes of Belamcanda chinensis

Biological Activity of 4',6,7-Trimethoxyisoflavone

Description4',6,7-Trimethoxyisoflavone promotes wound healing through NOX2 induction, which leads to collective migration and MMP activation.

4',6,7-Trimethoxyisoflavone Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

4',6,7-Trimethoxyisoflavone Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 4',6,7-Trimethoxyisoflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.202 mL 16.0102 mL 32.0205 mL 64.041 mL 80.0512 mL
5 mM 0.6404 mL 3.202 mL 6.4041 mL 12.8082 mL 16.0102 mL
10 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
50 mM 0.064 mL 0.3202 mL 0.6404 mL 1.2808 mL 1.601 mL
100 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on 4',6,7-Trimethoxyisoflavone

TMF and glycitin act synergistically on keratinocytes and fibroblasts to promote wound healing and anti-scarring activity.[Pubmed:28303029]

Exp Mol Med. 2017 Mar 17;49(3):e302.

Keratinocyte-fibroblast interactions are critical for skin repair after injury. During the proliferative phase of wound healing, proliferation, migration and differentiation of these cells are the major mechanisms leading to tissue remodeling. We have previously reported that glycitin, a major soy isoflavone, stimulates dermal fibroblast proliferation; and the phytochemical, 4',6,7-trimethoxyisoflavone (TMF), induces migration of HaCaT keratinocyte cells. We therefore investigated whether these compounds display synergistic effects on skin cells during wound healing in vitro and in vivo. Co-treatment with TMF and glycitin synergistically promotes the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy in our co-culture system. This keratinocyte-fibroblast interaction occurred via the secretion of TGF-beta, and the induction of differentiation and proliferation was confirmed in both indirect and direct co-culture assays. In an excisional and burn wound animal model, mice treated with a 1:1 ratio of TMF and glycitin showed faster wound closure, regeneration and scar reduction than even the positive control drug. These data indicate that two isoflavones, TMF and glycitin, act synergistically to promote wound healing and anti-scarring and could potentially be developed together as a bioactive therapeutic for wound treatment.

Flavonoids promoting HaCaT migration: II. Molecular mechanism of 4',6,7-trimethoxyisoflavone via NOX2 activation.[Pubmed:24388604]

Phytomedicine. 2014 Mar 15;21(4):570-7.

Flavonoids are major active ingredients in plants and are considered components of food that provide medical or health benefits. They have diversified structures and have effects on human health, including wound healing induction. More than a hundred flavonoids were screened for HaCaT keratinocytes cellular migration measurements and the relationships between their structural properties and the effects promoting cellular migration were examined. Here, among flavonoids used in the previous structure-activity relationship calculations, 4',6,7-trimethoxyisoflavone (TMF) was one of the compounds showing the best activity, so that its molecular mechanism of the wound healing effect on HaCaT keratinocytes was investigated in more detail. Our data revealed that TMF increased the wound healing rate, but not the proliferation rate, in a dose-dependent manner. Treatment of keratinocytes with TMF influenced signaling pathways, affecting the phosphorylation of AKT and ERK in a time-dependent manner. TMF also induced the cell-cell adhesion protein E-cadherin, which is essential for promoting collective cell migration. Furthermore, the TMF treatment group also showed higher ROS and NOX2 transcriptional and protein levels. Correlating with matrix metalloproteinase induction by TMF, levels of extracellular matrix proteins such as collagens I and III were significantly lower in the treatment group. To confirm that the effects of TMF occur through the NOX2 pathway, we co-treated cells with TMF plus an NADPH inhibitor (DPI) or a ROS scavenger (NAC). Western blotting revealed that DPI and NAC attenuated the effect of TMF, suggesting that TMF induces ROS through the NOX2 pathway and regulates keratinocyte migration. In summary, TMF promotes wound healing through NOX2 induction, which leads to collective migration and MMP activation.

New isoflavones, inhibiting catechol-O-methyltransferase, produced by Streptomyces.[Pubmed:1184476]

J Antibiot (Tokyo). 1975 Sep;28(9):619-26.

In the screening of catechol-O-methyltransferase inhibitors in streptomyces culture filtrates, three new isoflavones were isolated. Their structures were shown to be 3',5,7-trihydroxy-4',6-dimethoxyisoflavone (I), 3',5,7-trihydroxy-4',8-dimethoxyisoflavone (II), 3',8-dihydroxy-4',6,7-trimethoxyisoflavone (III). I and II inhibited both catechol-O-methyltransferase and dopa decarboxylase, and showed hypotensive action. III was a specific inhibitor of catechol-O-methyltransferase, and showed no hypotensive action.

Keywords:

4',6,7-Trimethoxyisoflavone,798-61-8,Natural Products, buy 4',6,7-Trimethoxyisoflavone , 4',6,7-Trimethoxyisoflavone supplier , purchase 4',6,7-Trimethoxyisoflavone , 4',6,7-Trimethoxyisoflavone cost , 4',6,7-Trimethoxyisoflavone manufacturer , order 4',6,7-Trimethoxyisoflavone , high purity 4',6,7-Trimethoxyisoflavone

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: