5'-DemethylaquillochinCAS# 305364-91-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 305364-91-4 | SDF | Download SDF |
| PubChem ID | 91885267 | Appearance | Powder |
| Formula | C20H18O9 | M.Wt | 402.4 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3R)-3-(3,4-dihydroxy-5-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one | ||
| SMILES | COC1=CC(=CC(=C1O)O)C2C(OC3=C4C(=CC(=C3O2)OC)C=CC(=O)O4)CO | ||
| Standard InChIKey | ATBGMZCSYDMJJM-RHSMWYFYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 5'-Demethylaquillochin exhibits the most potential chemopreventive ability. 2. 5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxification enzymes. |
| Targets | NADPH-oxidase | SOD |
5'-Demethylaquillochin Dilution Calculator
5'-Demethylaquillochin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4851 mL | 12.4254 mL | 24.8509 mL | 49.7018 mL | 62.1272 mL |
| 5 mM | 0.497 mL | 2.4851 mL | 4.9702 mL | 9.9404 mL | 12.4254 mL |
| 10 mM | 0.2485 mL | 1.2425 mL | 2.4851 mL | 4.9702 mL | 6.2127 mL |
| 50 mM | 0.0497 mL | 0.2485 mL | 0.497 mL | 0.994 mL | 1.2425 mL |
| 100 mM | 0.0249 mL | 0.1243 mL | 0.2485 mL | 0.497 mL | 0.6213 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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New hepatoprotective coumarinolignoids from Mallotus apelta.[Pubmed:18421750]
Chem Biodivers. 2008 Apr;5(4):591-7.
Three new coumarinolignoids, malloapelins A-C (1-3, resp.), together with three known coumarinolignoids, cleomiscosin A (4), cleomiscosin B (5), and 5'-demethylaquillochin (6), were isolated from the roots of Mallotus apelta MUELL.-ARG. Compounds 1-6 are three pairs of regioisomeric coumarinolignoids. Their structures were elucidated on the basis of spectral evidence. Compounds 3 showed promising hepatoprotective activity against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
Aromatic compounds and their antioxidant activity of Acer saccharum.[Pubmed:20686865]
J Nat Med. 2011 Jan;65(1):191-3.
A new lignan glycoside, 5-(3'',4''-dimethoxy-phenyl)-3-hydroxy-3-(4'-hydroxy-3'-methoxybenzyl)-4-hydroxym ethyl-dihydrofuran-2-one 4'-O-alpha-L: -rhamnopyranoside (1), with seven known compounds, compound 2, koaburside, icariside E(4), cleomiscosin C, cleomiscosin D, scopoletin, and 5'-demethylaquillochin, were isolated from the EtOH extract of the wood of Acer saccharum (Aceraceae). Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) and mass spectroscopy analysis. All of the isolated compounds, 1-8, were tested for their antioxidant activity in superoxide dismutase (SOD)-like assay.
Coumarinolignoids of Mallotus apelta.[Pubmed:10844178]
Fitoterapia. 2000 Jun;71(3):341-2.
Three coumarino-lignoids, aquillochin (1), cleomiscosin A and 5'-demethylaquillochin have been isolated from Mallotus apelta. The structure of the new compound 3 was determined by spectroscopic techniques.
Characterization of chemopreventive agents from the dichloromethane extract of Eurycorymbus cavaleriei by liquid chromatography-ion trap mass spectrometry.[Pubmed:19439309]
J Chromatogr A. 2009 Jun 12;1216(24):4859-67.
In the present study, we examined the potential chemopreventive activity of dichloromethane extract of Eurycorymbus cavaleriei by investigating the change of constitutions after incubation with glutathione (GSH). The major constitutions in the dichloromethane extract of E. cavaleriei were cumarin compounds and their cleavage pattern was examined by LC-MS-MS and the characteristic product ions at m/z 206 and 207 were helpful to determine the substitutions of coumarinolignoid compounds. The mechanism of conjugations of 5'-demethylaquillochin and its isomer with GSH was discussed and validated through analysis of the conjugations of reference compound 6-hydroxy-7-methoxycoumarin with GSH by LC-MS-MS and NMR spectrum. The relative ability to induce the detoxification enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1) of nine coumarin compounds was tested which also showed 5'-demethylaquillochin exhibited the most potential chemopreventive ability. These observations suggest that 5'-demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxification enzymes.
