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6-O-Nicotinoylscutebarbatine G

CAS# 1206805-30-2

6-O-Nicotinoylscutebarbatine G

Catalog No. BCN7296----Order now to get a substantial discount!

Product Name & Size Price Stock
6-O-Nicotinoylscutebarbatine G: 5mg $989 In Stock
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Quality Control of 6-O-Nicotinoylscutebarbatine G

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Chemical structure

6-O-Nicotinoylscutebarbatine G

3D structure

Chemical Properties of 6-O-Nicotinoylscutebarbatine G

Cas No. 1206805-30-2 SDF Download SDF
PubChem ID 129317383 Appearance Powder
Formula C32H36N2O8 M.Wt 576.64
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [6-(cyclopenta-1,3,4-triene-1-carbonyloxy)-5-hydroxy-4a,6a,7,10b-tetramethyl-2'-oxospiro[2,5,6,9,10,10a-hexahydro-1H-benzo[f]chromene-3,4'-oxolane]-10-yl] cyclopenta-1,3,4-triene-1-carboxylate
SMILES CC1=CCC(C2C1(C(C(C3(C2(CCC4(O3)CC(=O)OC4)C)C)O)OC(=O)C5=CC=C=C5)C)OC(=O)C6=CC=C=C6
Standard InChIKey AJBAUCYKHLPPHC-UHFFFAOYSA-N
Standard InChI InChI=1S/C32H34O8/c1-19-13-14-22(38-27(35)20-9-5-6-10-20)24-29(2)15-16-32(17-23(33)37-18-32)40-31(29,4)25(34)26(30(19,24)3)39-28(36)21-11-7-8-12-21/h5,7,9-13,22,24-26,34H,14-18H2,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 6-O-Nicotinoylscutebarbatine G

The whole plants of Scutellaria barbata.

Biological Activity of 6-O-Nicotinoylscutebarbatine G

Description1. 6-O-Nicotinoylscutebarbatine G shows cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in the range of 2.1–5.7 uM.

6-O-Nicotinoylscutebarbatine G Dilution Calculator

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6-O-Nicotinoylscutebarbatine G Molarity Calculator

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Preparing Stock Solutions of 6-O-Nicotinoylscutebarbatine G

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7342 mL 8.6709 mL 17.3418 mL 34.6837 mL 43.3546 mL
5 mM 0.3468 mL 1.7342 mL 3.4684 mL 6.9367 mL 8.6709 mL
10 mM 0.1734 mL 0.8671 mL 1.7342 mL 3.4684 mL 4.3355 mL
50 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.6937 mL 0.8671 mL
100 mM 0.0173 mL 0.0867 mL 0.1734 mL 0.3468 mL 0.4335 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 6-O-Nicotinoylscutebarbatine G

Scutebarbatines W-Z, new neo-clerodane diterpenoids from Scutellaria barbata and structure revision of a series of 13-spiro neo-clerodanes.[Pubmed:20823615]

Chem Pharm Bull (Tokyo). 2010 Sep;58(9):1267-70.

Four new neo-clerodane diterpenoids, scutebarbatines W-Z (1-4), were isolated from the ethanol extract of Scutellaria barbata (Labiatae), and their structures were elucidated on the basis of extensive spectroscopic studies. In addition, the proposed structures of at least seven 13-spiro subtype neo-clerodanes: scutehenanine B (5), scutebarbatine G (6), 6-O-Nicotinoylscutebarbatine G (7), barbatin A (8), 6,7-di-O-nicotinoylscutebarbatine G (9), 6-O-nicotinoyl-7-O-acetylscutebarbatine G (10), and scutebarbatine F (11), reported by Dai and co-workers from the same species, were incorrectly assigned and have been revised by reanalysis of the published NMR data.

Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities.[Pubmed:19504388]

J Asian Nat Prod Res. 2009;11(5):451-6.

Two new neo-clerodane diterpenoid alkaloids, scutebarbatine O (1) and 6-O-Nicotinoylscutebarbatine G (2), were isolated from the whole plant of Scutellaria barbata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1 and 2 showed cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 2.1-5.7 microM.

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