Scutebarbatine WCAS# 1312716-25-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1312716-25-8 | SDF | Download SDF |
PubChem ID | 124581334 | Appearance | Powder |
Formula | C33H37NO8 | M.Wt | 575.65 |
Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | [(3R,4aR,5S,6R,6aR,10R,10aS,10bR)-10-benzoyloxy-5-hydroxy-4a,6a,7,10b-tetramethyl-2'-oxospiro[2,5,6,9,10,10a-hexahydro-1H-benzo[f]chromene-3,4'-oxolane]-6-yl] pyridine-3-carboxylate | ||
SMILES | CC1=CCC(C2C1(C(C(C3(C2(CCC4(O3)CC(=O)OC4)C)C)O)OC(=O)C5=CN=CC=C5)C)OC(=O)C6=CC=CC=C6 | ||
Standard InChIKey | LHDUPMAARYESGH-JIYIMHFPSA-N | ||
Standard InChI | InChI=1S/C33H37NO8/c1-20-12-13-23(40-28(37)21-9-6-5-7-10-21)25-30(2)14-15-33(17-24(35)39-19-33)42-32(30,4)26(36)27(31(20,25)3)41-29(38)22-11-8-16-34-18-22/h5-12,16,18,23,25-27,36H,13-15,17,19H2,1-4H3/t23-,25-,26+,27+,30-,31+,32+,33-/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Scutebarbatine W can inhibit nitric oxide production efficiently with IC50 values of lower than 50 uM, it may have potential effects on the reduction of neuroinflammation. |
Targets | NO |
Scutebarbatine W Dilution Calculator
Scutebarbatine W Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.7372 mL | 8.6858 mL | 17.3717 mL | 34.7433 mL | 43.4292 mL |
5 mM | 0.3474 mL | 1.7372 mL | 3.4743 mL | 6.9487 mL | 8.6858 mL |
10 mM | 0.1737 mL | 0.8686 mL | 1.7372 mL | 3.4743 mL | 4.3429 mL |
50 mM | 0.0347 mL | 0.1737 mL | 0.3474 mL | 0.6949 mL | 0.8686 mL |
100 mM | 0.0174 mL | 0.0869 mL | 0.1737 mL | 0.3474 mL | 0.4343 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Antibiotic PF 1018
Catalog No.:BCN2149
CAS No.:131256-42-3
- PF 5081090
Catalog No.:BCC6148
CAS No.:1312473-63-4
- Cornuside
Catalog No.:BCN5007
CAS No.:131189-57-6
- NSC 624206
Catalog No.:BCC7988
CAS No.:13116-77-3
- Sodium Demethylcantharidate
Catalog No.:BCN8394
CAS No.:13114-29-9
- mGlu2 agonist
Catalog No.:BCC1745
CAS No.:1311385-32-6
- BIX 02565
Catalog No.:BCC4303
CAS No.:1311367-27-7
- 5,7-Dichlorokynurenic acid
Catalog No.:BCC6592
CAS No.:131123-76-7
- Miltipolone
Catalog No.:BCN3222
CAS No.:131086-61-8
- NVP-BGJ398 phosphate
Catalog No.:BCC1814
CAS No.:1310746-10-1
- Tubastatin A HCl
Catalog No.:BCC3877
CAS No.:1310693-92-5
- NB-598
Catalog No.:BCC1786
CAS No.:131060-14-5
- Scutebarbatine X
Catalog No.:BCN6997
CAS No.:1312716-26-9
- Scutebarbatine Y
Catalog No.:BCN6994
CAS No.:1312716-27-0
- Scutebarbatine Z
Catalog No.:BCN6991
CAS No.:1312716-28-1
- Ro 25-6981 Maleate
Catalog No.:BCC4159
CAS No.:1312991-76-6
- Ro 8-4304 hydrochloride
Catalog No.:BCC7655
CAS No.:1312991-77-7
- threo Ifenprodil hemitartrate
Catalog No.:BCC7508
CAS No.:1312991-83-5
- Nystose
Catalog No.:BCN5397
CAS No.:13133-07-8
- NVP-CGM097
Catalog No.:BCC5395
CAS No.:1313363-54-0
- erythro-Guaiacylglycerol beta-threo-syringylglycerol ether
Catalog No.:BCN7333
CAS No.:1313434-74-0
- Periplocin
Catalog No.:BCN2655
CAS No.:13137-64-9
- Teijin compound 1
Catalog No.:BCC6057
CAS No.:1313730-14-1
- Boc-Trp-OH
Catalog No.:BCC3455
CAS No.:13139-14-5
Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells.[Pubmed:28805952]
Chem Biodivers. 2017 Nov;14(11).
The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as Scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7), and scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50 mum. Particularly, compounds 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4 mum, respectively. This is the first report suggesting the potential of S. barbata on the reduction of neuroinflammation.