(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-oneCAS# 120693-49-4 |
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| Cas No. | 120693-49-4 | SDF | Download SDF |
| PubChem ID | 5319810 | Appearance | Oil |
| Formula | C21H29NO | M.Wt | 311.46 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1-methyl-2-[(Z)-undec-6-enyl]quinolin-4-one | ||
| SMILES | CCCCC=CCCCCCC1=CC(=O)C2=CC=CC=C2N1C | ||
| Standard InChIKey | ILAQTUNYLVMXNW-SREVYHEPSA-N | ||
| Standard InChI | InChI=1S/C21H29NO/c1-3-4-5-6-7-8-9-10-11-14-18-17-21(23)19-15-12-13-16-20(19)22(18)2/h6-7,12-13,15-17H,3-5,8-11,14H2,1-2H3/b7-6- | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The fruits of Evodia rutaecarpa (Juss.) Benth.
| Description | 1. (Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one shows strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes, and it is very effective against mycobacteria. |
| Targets | Antifection |
(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one Dilution Calculator
(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2107 mL | 16.0534 mL | 32.1069 mL | 64.2137 mL | 80.2671 mL |
| 5 mM | 0.6421 mL | 3.2107 mL | 6.4214 mL | 12.8427 mL | 16.0534 mL |
| 10 mM | 0.3211 mL | 1.6053 mL | 3.2107 mL | 6.4214 mL | 8.0267 mL |
| 50 mM | 0.0642 mL | 0.3211 mL | 0.6421 mL | 1.2843 mL | 1.6053 mL |
| 100 mM | 0.0321 mL | 0.1605 mL | 0.3211 mL | 0.6421 mL | 0.8027 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Evaluation of the Anti-inflammatory Potential of Chinese Botanicals
Planta Medica, 2009, 75(4):401-402.
Traditional Chinese medicine (TCM) has been using about 1300 plants for anti-inflammatory purposes. Activity guided isolation in a medium throughput approach has resulted in the discovery of a number of new drug leads. From the fruits of Evodia rutaecarpa (Juss.) Benth. (Rutaceae), several quinolinone alkaloids, like 1-methyl-2-nonyl-4(1H)-quinolinone, 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone((Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one ), 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evo-carpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone, have been isolated which showed strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes [1]. They showed no cytotoxic activity and might bind to the lipid binding site of 5-LOX [2]. Moreover they were very effective against mycobacteria [3].
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