6alpha-Hydroxypolyporenic acid CCAS# 24513-63-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 24513-63-1 | SDF | Download SDF |
| PubChem ID | 101280198 | Appearance | Powder |
| Formula | C31H46O5 | M.Wt | 498.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R)-2-[(5R,6S,10S,13R,14R,16R,17R)-6,16-dihydroxy-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid | ||
| SMILES | CC(C)C(=C)CCC(C1C(CC2(C1(CC=C3C2=CC(C4C3(CCC(=O)C4(C)C)C)O)C)C)O)C(=O)O | ||
| Standard InChIKey | NRSIOSASQDHZSI-OTNSLKBZSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 6alpha-Hydroxypolyporenic acid C is a natural product from Wolfiporia cocos (Schw.) Ryv. |
| In vitro | Absorption of triterpenoid compounds from Indian bread (Poria cocos) across human intestinal epithelial (Caco-2) cells in vitro.[Pubmed: 18837324]Zhongguo Zhong Yao Za Zhi. 2008 Jul;33(13):1596-601.To study the absorption of 3-epidehydrotumulosic acid (EDHTA), polyporenic acid C (PPAC) and 6alpha-Hydroxypolyporenic acid C (HPPA) isolated from the sclerotium of Poria cocos. In human intestinal epithelial. |
6alpha-Hydroxypolyporenic acid C Dilution Calculator
6alpha-Hydroxypolyporenic acid C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0052 mL | 10.0261 mL | 20.0521 mL | 40.1043 mL | 50.1303 mL |
| 5 mM | 0.401 mL | 2.0052 mL | 4.0104 mL | 8.0209 mL | 10.0261 mL |
| 10 mM | 0.2005 mL | 1.0026 mL | 2.0052 mL | 4.0104 mL | 5.013 mL |
| 50 mM | 0.0401 mL | 0.2005 mL | 0.401 mL | 0.8021 mL | 1.0026 mL |
| 100 mM | 0.0201 mL | 0.1003 mL | 0.2005 mL | 0.401 mL | 0.5013 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Absorption of triterpenoid compounds from Indian bread (Poria cocos) across human intestinal epithelial (Caco-2) cells in vitro].[Pubmed:18837324]
Zhongguo Zhong Yao Za Zhi. 2008 Jul;33(13):1596-601.
OBJECTIVE: To study the absorption of 3-epidehydrotumulosic acid (EDHTA), polyporenic acid C (PPAC) and 6alpha-Hydroxypolyporenic acid C (HPPA) isolated from the sclerotium of Poria cocos. In human intestinal epithelial. METHOD: By using Caco-2 (the human colonic adenocarcinoma cell lines) cells monolayer as an intestinal epithelial cell model, the permeability of EDHTA, PPAC and HPPA were studied from apical side (AP side) to basolateral side (BL side) or from BL side to AP side. The three compounds were measured by reversed-phase high performance liquid chromatography (HPLC) coupled with UV detector. Transport parameters and apparent permeability coefficients (P(app)) were then calculated and compared with those of propranolol and atenolol, which are the transcellular transport marker and as a control substance for high and poor permeability, respectively. RESULT: The P(app) values of EDHTA, PPAC and HPPA were (9.99 +/- 1.08) x 10(-6), (10.06 +/- 0.53) x 10(-6) and (3.32 +/- 0.66) x 10(-6) cm x s(-1) from AP side to BL side, and (17.76 +/- 0.91) x 10(-6), (19.23 +/- 1.16) x 10(-6) and (8.19 +/- 0.57) x 10(-6) cm x s(-1) from BL side to AP side,respectively. Under the condition of this experiment, the P(app) value was 1.45 x 10(-5) cm x s(-1) for propranolol and 4.22 x 0(-7) cm x s(-1) for atenolol. The P(app) values of EDHTA and PPAC were at a nearly same magnitude with those of propranolol, and HPPA lied between those of propranolol and atenolol. On the other hand, the efflux transport of EDHTA, PPAC and HPPA were higher 1.78, 1.91 and 2. 47 times more than its influx transport with 0.56, 0.52 and 0.41 rate of P(app A --> B)/P(app (B --> A). CONCLUSION: EDHTA, PPAC and HPPA can be absorbed across intestinal epithelial cells, among EDHTA and PPAC will be completely. HPPA will be moderately absorbed compounds. EDHTA, PPAC and HPPA may have been involved in efflux mechanism in Caco-2 cells monolayers model from the basolateral-to-apical direction.
