Home >> Research Area >>Natural Products>>Diterpenoids>> Monomethyl kolavate

Monomethyl kolavate

CAS# 24513-41-5

Monomethyl kolavate

Catalog No. BCN5105----Order now to get a substantial discount!

Product Name & Size Price Stock
Monomethyl kolavate: 5mg $886 In Stock
Monomethyl kolavate: 10mg Please Inquire In Stock
Monomethyl kolavate: 20mg Please Inquire Please Inquire
Monomethyl kolavate: 50mg Please Inquire Please Inquire
Monomethyl kolavate: 100mg Please Inquire Please Inquire
Monomethyl kolavate: 200mg Please Inquire Please Inquire
Monomethyl kolavate: 500mg Please Inquire Please Inquire
Monomethyl kolavate: 1000mg Please Inquire Please Inquire

Quality Control of Monomethyl kolavate

Number of papers citing our products

Chemical structure

Monomethyl kolavate

3D structure

Chemical Properties of Monomethyl kolavate

Cas No. 24513-41-5 SDF Download SDF
PubChem ID 11462192 Appearance Powder
Formula C21H32O4 M.Wt 348.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (4aR,5S,6R,8aR)-5-[(E)-5-methoxy-3-methyl-5-oxopent-3-enyl]-5,6,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalene-1-carboxylic acid
SMILES CC1CCC2(C(C1(C)CCC(=CC(=O)OC)C)CCC=C2C(=O)O)C
Standard InChIKey CCDSRPQULZAXRF-LIECZFJOSA-N
Standard InChI InChI=1S/C21H32O4/c1-14(13-18(22)25-5)9-11-20(3)15(2)10-12-21(4)16(19(23)24)7-6-8-17(20)21/h7,13,15,17H,6,8-12H2,1-5H3,(H,23,24)/b14-13+/t15-,17-,20+,21+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Monomethyl kolavate

The wood of Gossweilerodendron balsamiferum

Biological Activity of Monomethyl kolavate

Description1. Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM.
TargetsAntifection

Monomethyl kolavate Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Monomethyl kolavate Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Monomethyl kolavate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8694 mL 14.3472 mL 28.6944 mL 57.3888 mL 71.736 mL
5 mM 0.5739 mL 2.8694 mL 5.7389 mL 11.4778 mL 14.3472 mL
10 mM 0.2869 mL 1.4347 mL 2.8694 mL 5.7389 mL 7.1736 mL
50 mM 0.0574 mL 0.2869 mL 0.5739 mL 1.1478 mL 1.4347 mL
100 mM 0.0287 mL 0.1435 mL 0.2869 mL 0.5739 mL 0.7174 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Monomethyl kolavate

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.[Pubmed:26404225]

Molecules. 2015 Sep 3;20(9):16154-69.

As part of our ongoing efforts to identify natural products with activity against pathogens causing neglected tropical diseases, we are currently performing an extensive screening of natural product (NP) databases against a multitude of protozoan parasite proteins. Within this project, we screened a database of NPs from a commercial supplier, AnalytiCon Discovery (Potsdam, Germany), against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH), a glycolytic enzyme whose inhibition deprives the parasite of energy supply. NPs acting as potential inhibitors of the mentioned enzyme were identified using a pharmacophore-based virtual screening and subsequent docking of the identified hits into the active site of interest. In a set of 700 structures chosen for the screening, 13 (1.9%) were predicted to possess significant affinity towards the enzyme and were therefore tested in an in vitro enzyme assay using recombinant TbGAPDH. Nine of these in silico hits (69%) showed significant inhibitory activity at 50 microM, of which two geranylated benzophenone derivatives proved to be particularly active with IC50 values below 10 microM. These compounds also showed moderate in vitro activity against T. brucei rhodesiense and may thus represent interesting starting points for further optimization.

Keywords:

Monomethyl kolavate,24513-41-5,Natural Products, buy Monomethyl kolavate , Monomethyl kolavate supplier , purchase Monomethyl kolavate , Monomethyl kolavate cost , Monomethyl kolavate manufacturer , order Monomethyl kolavate , high purity Monomethyl kolavate

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: